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Nrg3 neuregulin 3 [ Mus musculus (house mouse) ]

Gene ID: 18183, updated on 5-Mar-2024

Summary

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Official Symbol
Nrg3provided by MGI
Official Full Name
neuregulin 3provided by MGI
Primary source
MGI:MGI:1097165
See related
Ensembl:ENSMUSG00000041014 AllianceGenome:MGI:1097165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ska
Summary
Enables chemorepellent activity. Acts upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space and glutamatergic synapse. Is expressed in several structures, including epidermis; mammary gland primordium; nervous system; testis; and trunk mesenchyme. Used to study schizophrenia. Orthologous to human NRG3 (neuregulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.1), frontal lobe adult (RPKM 3.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14; 14 B
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (38086093..39195045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (38365102..39473235, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36433 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36435 Neighboring gene STARR-seq mESC enhancer starr_36436 Neighboring gene STARR-seq mESC enhancer starr_36437 Neighboring gene STARR-seq mESC enhancer starr_36439 Neighboring gene predicted gene, 31456 Neighboring gene STARR-seq mESC enhancer starr_36440 Neighboring gene STARR-seq mESC enhancer starr_36441 Neighboring gene cytochrome c oxidase, subunit VIIc pseudogene Neighboring gene STARR-seq mESC enhancer starr_36442 Neighboring gene STARR-seq mESC enhancer starr_36443 Neighboring gene STARR-seq mESC enhancer starr_36444 Neighboring gene predicted gene, 53854 Neighboring gene STARR-seq mESC enhancer starr_36445 Neighboring gene neuregulin 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_36446 Neighboring gene STARR-seq mESC enhancer starr_36447 Neighboring gene predicted gene 20642 Neighboring gene predicted gene, 31606 Neighboring gene uncharacterized LOC432842 Neighboring gene potassium channel modulatory factor 1 pseudogene Neighboring gene RIKEN cDNA 1700109I08 gene Neighboring gene STARR-seq mESC enhancer starr_36448 Neighboring gene predicted gene, 35389

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders. Hayes LN, et al. Mol Neuropsychiatry, 2016 Jul. PMID 27606322, Free PMC Article
  2. Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action. Loos M, et al. Biol Psychiatry, 2014 Oct 15. PMID 24703509
  3. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Wang YN, et al. Proc Natl Acad Sci U S A, 2018 Mar 6. PMID 29463705, Free PMC Article
  4. [Neuregulin promotes spermatogonia proliferation in mice]. Jin YJ, et al. Zhonghua Nan Ke Xue, 2011 May. PMID 21837948
  5. Neuregulin3 alters cell fate in the epidermis and mammary gland. Panchal H, et al. BMC Dev Biol, 2007 Sep 19. PMID 17880691, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.
    Title: In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.
  2. Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
    Title: Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
  3. data indicate that Nrg3 provides adhesive cues that facilitate excitatory neurons to synapse onto ErbB4(+) interneurons.
    Title: Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
  4. Studied the physiologic role of neuregulin3 (NRG3) in regulating glutamatergic transmission in pyramidal neurons. Found NRG3 regulates the SNARE-complex assembly, and NRG3 knockout causes display behavior deficits related to mental illness.
    Title: Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex.
  5. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits.
    Title: Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons.
  6. This study demonistrated that Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
    Title: Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
  7. NRG1beta and NRG3 can promote the proliferation of mouse spermatogonia.
    Title: [Neuregulin promotes spermatogonia proliferation in mice].
  8. used positional cloning to narrow the interval containing scaramanga (ska) to a 75.6-kb interval containing the distal part of the Neuregulin3 (Nrg3) gene
    Title: Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification.
  9. a Neuregulin3 signaling pathway is involved in specification of mammary gland morphogenesis
    Title: Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chemorepellent activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERBB4 signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in ERBB4-ERBB4 signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mammary gland development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mammary placode formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
pro-neuregulin-3, membrane-bound isoform
Names
pro-NRG3
scaramanga

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190187.1 → NP_001177116.1  pro-neuregulin-3, membrane-bound isoform isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC109253, AC154426, CT025583, CT025629, CT030231
    UniProtKB/TrEMBL
    B9EHF8
    Conserved Domains (2) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:354 → 401
    Neuregulin; Neuregulin family

  2. NM_001190188.1 → NP_001177117.1  pro-neuregulin-3, membrane-bound isoform isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC109253, AC154426, CT025583, CT025629, CT030231
    Consensus CDS
    CCDS49450.1
    UniProtKB/TrEMBL
    B7ZN23, E9Q396
    Related
    ENSMUSP00000129783.3, ENSMUST00000168810.9
    Conserved Domains (2) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:355 → 402
    Neuregulin; Neuregulin family

  3. NM_008734.3 → NP_032760.1  pro-neuregulin-3, membrane-bound isoform isoform 1

    See identical proteins and their annotated locations for NP_032760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC109253, AC154426, CT025583, CT025629, CT030231
    Consensus CDS
    CCDS26954.1
    UniProtKB/Swiss-Prot
    O35181
    UniProtKB/TrEMBL
    B9EHF8
    Related
    ENSMUSP00000136884.2, ENSMUST00000166968.9
    Conserved Domains (2) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:355 → 402
    Neuregulin; Neuregulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    38086093..39195045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158506.1 → XP_036014399.1  pro-neuregulin-3, membrane-bound isoform isoform X9

    UniProtKB/TrEMBL
    B7ZN23
    Conserved Domains (1) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional

  2. XM_006518687.5 → XP_006518750.1  pro-neuregulin-3, membrane-bound isoform isoform X7

    UniProtKB/TrEMBL
    B7ZN23
    Conserved Domains (2) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional
    COG5160
    Location:351 → 563
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  3. XM_036158505.1 → XP_036014398.1  pro-neuregulin-3, membrane-bound isoform isoform X4

    UniProtKB/TrEMBL
    B9EHF8
    Conserved Domains (1) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional

  4. XM_030247684.2 → XP_030103544.1  pro-neuregulin-3, membrane-bound isoform isoform X5

    UniProtKB/TrEMBL
    B7ZN23
    Conserved Domains (2) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional
    COG5160
    Location:351 → 564
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  5. XM_011244987.4 → XP_011243289.1  pro-neuregulin-3, membrane-bound isoform isoform X2

    UniProtKB/TrEMBL
    B9EHF8
    Conserved Domains (1) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional

  6. XM_017315911.3 → XP_017171400.1  pro-neuregulin-3, membrane-bound isoform isoform X8

    UniProtKB/TrEMBL
    B7ZN23, G3V023
    Related
    ENSMUSP00000134727.2, ENSMUST00000173780.2
    Conserved Domains (1) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional

  7. XM_006518686.5 → XP_006518749.1  pro-neuregulin-3, membrane-bound isoform isoform X6

    UniProtKB/TrEMBL
    B7ZN23
    Conserved Domains (2) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional
    COG5160
    Location:352 → 564
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  8. XM_006518685.5 → XP_006518748.1  pro-neuregulin-3, membrane-bound isoform isoform X3

    UniProtKB/TrEMBL
    B9EHF8
    Conserved Domains (1) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional

  9. XM_017315910.3 → XP_017171399.1  pro-neuregulin-3, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    B9EHF8
    Conserved Domains (1) summary
    PHA02887
    Location:280 → 333
    PHA02887; EGF-like protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35181.1 GenPept UniProtKB/Swiss-Prot:O35181

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