sex-1 Steroid hormone receptor family member cnr14 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: sex-1
Gene description: Steroid hormone receptor family member cnr14
Primary source: WormBase:WBGene00004786
Locus tag: CELE_F44A6.2
See related: AllianceGenome:WB:WBGene00004786
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in primary sex determination and regulation of gene expression. Located in nucleus. Is expressed in gonad; intestine; oocyte; and ventral uterine precursor. Human ortholog(s) of this gene implicated in several diseases, including acute promyelocytic leukemia; cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); and lung carcinoma (multiple). Orthologous to several human genes including RARA (retinoic acid receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See sex-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (10201329..10205421, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS6-171 (e-PCR)
- UniSTS:242553

F44A6.2 (e-PCR)
- UniSTS:321470

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in dosage compensation by hypoactivation of X chromosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dosage compensation by hypoactivation of X chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in primary sex determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in primary sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Steroid hormone receptor family member cnr14

NP_001024662.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10201329..10205421 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029491.5 → NP_001024662.1 Steroid hormone receptor family member cnr14 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024662.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41830

UniProtKB/TrEMBL

Q9XXU7

Conserved Domains (2) summary

cd06942
Location:296 → 488

NR_LBD_Sex_1_like; The ligand binding domain of Caenorhabditis elegans nuclear hormone receptor Sex-1 protein

cd07165
Location:151 → 231

NR_DBD_DmE78_like; DNA-binding domain of Drosophila ecdysone-induced protein 78 (E78) like is composed of two C4-type zinc fingers