U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nnt nicotinamide nucleotide transhydrogenase [ Mus musculus (house mouse) ]

Gene ID: 18115, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Nntprovided by MGI
Official Full Name
nicotinamide nucleotide transhydrogenaseprovided by MGI
Primary source
MGI:MGI:109279
See related
Ensembl:ENSMUSG00000116207 AllianceGenome:MGI:109279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930423F13Rik
Summary
Predicted to enable NAD binding activity; NAD(P)+ transhydrogenase activity; and NADP binding activity. Predicted to be involved in several processes, including cell redox homeostasis; oxygen homeostasis; and positive regulation of hydrogen peroxide catabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; musculature; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 133.4), kidney adult (RPKM 53.7) and 23 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
13 D2.3; 13 67.21 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (119472063..119545793, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (119335527..119409257, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Fgf10 5' regulatory region Neighboring gene VISTA enhancer mm917 Neighboring gene Fgf10 intronic enhancer Neighboring gene STARR-seq mESC enhancer starr_35795 Neighboring gene fibroblast growth factor 10 Neighboring gene VISTA enhancer mm605 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35797 Neighboring gene STARR-seq mESC enhancer starr_35799 Neighboring gene STARR-seq mESC enhancer starr_35800 Neighboring gene STARR-seq mESC enhancer starr_35802 Neighboring gene STARR-seq mESC enhancer starr_35803 Neighboring gene STARR-seq mESC enhancer starr_35804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:120196902-120197103 Neighboring gene RIKEN cDNA 4833420G17 gene Neighboring gene STARR-positive B cell enhancer ABC_E7292 Neighboring gene polyadenylate binding protein-interacting protein 1 Neighboring gene predicted gene 9752

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Loss of Nnt Increases Expression of Oxidative Phosphorylation Complexes in C57BL/6J Hearts. Williams JL, et al. Int J Mol Sci, 2021 Jun 5. PMID 34198873, Free PMC Article
  2. NADPH supply and the contribution of NAD(P)(+) transhydrogenase (NNT) to H(2)O(2) balance in skeletal muscle mitochondria. Figueira TR, et al. Arch Biochem Biophys, 2021 Aug 15. PMID 34043997
  3. Undesirable effects of chemical inhibitors of NAD(P)(+) transhydrogenase on mitochondrial respiratory function. Bicego R, et al. Arch Biochem Biophys, 2020 Oct 15. PMID 32781052
  4. Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure. Smith CD, et al. J Biol Chem, 2020 Nov 27. PMID 32747443, Free PMC Article
  5. Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice. Kunath A, et al. Horm Metab Res, 2020 Dec. PMID 32629517

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin-specific peptidase 47 (USP47) regulates cutaneous oxidative injury through nicotinamide nucleotide transhydrogenase (NNT).
    Title: Ubiquitin-specific peptidase 47 (USP47) regulates cutaneous oxidative injury through nicotinamide nucleotide transhydrogenase (NNT).
  2. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.
    Title: NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.
  3. NADPH supply and the contribution of NAD(P)(+) transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria.
    Title: NADPH supply and the contribution of NAD(P)(+) transhydrogenase (NNT) to H(2)O(2) balance in skeletal muscle mitochondria.
  4. Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice.
    Title: Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice.
  5. Loss of Nnt Increases Expression of Oxidative Phosphorylation Complexes in C57BL/6J Hearts.
    Title: Loss of Nnt Increases Expression of Oxidative Phosphorylation Complexes in C57BL/6J Hearts.
  6. Selective NADH communication from alpha-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart.
    Title: Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart.
  7. Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not.
    Title: Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not.
  8. Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure.
    Title: Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure.
  9. Undesirable effects of chemical inhibitors of NAD(P)(+) transhydrogenase on mitochondrial respiratory function.
    Title: Undesirable effects of chemical inhibitors of NAD(P)(+) transhydrogenase on mitochondrial respiratory function.
  10. the role of NNT in the brain mitochondria redox balance especially comes into play under mitochondrial respiratory defects or high-fat diet
    Title: Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD(P)+ transhydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADP binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADPH regeneration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADPH regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular oxidant detoxification ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular oxygen homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NAD(P) transhydrogenase, mitochondrial
Names
pyridine nucleotide transhydrogenase
NP_001295435.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308506.1 → NP_001295435.1  NAD(P) transhydrogenase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001295435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the sequence transcribed from this locus in C57BL/6, which lacks five in-frame internal exons, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC154550, AK054332, BP768059, BY078900, BY093825
    Consensus CDS
    CCDS84067.1
    UniProtKB/TrEMBL
    Q8BGK0, Q8C9V5
    Related
    ENSMUSP00000152868.2, ENSMUST00000223268.2
    Conserved Domains (2) summary
    pfam02233
    Location:371 → 828
    PNTB; NAD(P) transhydrogenase beta subunit
    cl21454
    Location:57 → 369
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_008710.3 → NP_032736.2  NAD(P) transhydrogenase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_032736.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This variant is not transcribed from this locus in C57BL/6, which lacks five in-frame internal exons.
    Source sequence(s)
    AK090115
    UniProtKB/Swiss-Prot
    Q61941, Q9JK70
    UniProtKB/TrEMBL
    Q8C1W8, Q922E1
    Conserved Domains (4) summary
    PRK09424
    Location:57 → 587
    pntA; NAD(P) transhydrogenase subunit alpha; Provisional
    cd05304
    Location:57 → 432
    Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains
    pfam02233
    Location:622 → 1079
    PNTB; NAD(P) transhydrogenase beta subunit
    pfam12769
    Location:502 → 587
    PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    119472063..119545793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61941.2 GenPept UniProtKB/Swiss-Prot:Q61941

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous