U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nfya nuclear transcription factor-Y alpha [ Mus musculus (house mouse) ]

Gene ID: 18044, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Nfyaprovided by MGI
Official Full Name
nuclear transcription factor-Y alphaprovided by MGI
Primary source
MGI:MGI:97316
See related
Ensembl:ENSMUSG00000023994 AllianceGenome:MGI:97316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbf-b; SEZ10; SEZ-10
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of stem cell proliferation; positive regulation of transcription, DNA-templated; and regulation of stem cell population maintenance. Located in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 28.3), ovary adult (RPKM 24.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 C; 17 23.99 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48693917..48716782, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48386885..48409820, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells 2 Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10961 Neighboring gene STARR-positive B cell enhancer ABC_E2492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48549466-48549575 Neighboring gene STARR-positive B cell enhancer ABC_E7541 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 Neighboring gene predicted gene, 30283

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nuclear Factor-Y in Mouse Pancreatic β-Cells Plays a Crucial Role in Glucose Homeostasis by Regulating β-Cell Mass and Insulin Secretion. Liu Y, et al. Diabetes, 2021 Aug. PMID 33980692
  2. The Switch from NF-YAl to NF-YAs Isoform Impairs Myotubes Formation. Libetti D, et al. Cells, 2020 Mar 24. PMID 32214056, Free PMC Article
  3. NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region. Oldfield AJ, et al. Nat Commun, 2019 Jul 11. PMID 31296853, Free PMC Article
  4. Obesity-induced endoplasmic reticulum stress suppresses nuclear factor-Y expression. Liu Y, et al. Mol Cell Biochem, 2017 Feb. PMID 27837431
  5. Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression. Lu YH, et al. Mol Metab, 2015 May. PMID 25973387, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development.
    Title: The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development.
  2. Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development.
    Title: Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development.
  3. Nuclear Factor-Y in Mouse Pancreatic beta-Cells Plays a Crucial Role in Glucose Homeostasis by Regulating beta-Cell Mass and Insulin Secretion.
    Title: Nuclear Factor-Y in Mouse Pancreatic β-Cells Plays a Crucial Role in Glucose Homeostasis by Regulating β-Cell Mass and Insulin Secretion.
  4. Nuclear factor Y participates in alcoholic liver disease by activating SREBP1 expression in mice.
    Title: Nuclear factor Y participates in alcoholic liver disease by activating SREBP1 expression in mice.
  5. The Switch from NF-YAl to NF-YAs Isoform Impairs Myotubes Formation.
    Title: The Switch from NF-YAl to NF-YAs Isoform Impairs Myotubes Formation.
  6. Through genome-wide studies in mouse embryonic stem cells study finds that NF-Y is essential for the maintenance of the nucleosome-depleted region at gene promoters. Depletion of the NF-YA protein leads to the accumulation of ectopic nucleosomes over the transcription start site, reducing promoter accessibility.
    Title: NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region.
  7. The results reveal a previously unrecognized physiological function of NFYA in controlling glucose metabolism by up-regulating the gluconeogenic genes Pck1 and G6pc.
    Title: Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice.
  8. Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states.
    Title: A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes.
  9. findings may point to a possible role of NF-YA in stress conditions that occur in chronic obesity, ER stress might be involved in the pathogenesis of obesity through NF-YA depletion.
    Title: Obesity-induced endoplasmic reticulum stress suppresses nuclear factor-Y expression.
  10. we conclude that NF-Y and YY1 are important for the basal transcription of Pcyt2 and that NF-Y is involved in the inhibitory effects of 25-HC on Pcyt2 transcription.
    Title: Transcriptional suppression of CTP:phosphoethanolamine cytidylyltransferase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang 1.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear transcription factor Y subunit alpha
Names
CAAT box DNA-binding protein subunit A
nuclear transcription factor Y subunit A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110832.2 → NP_001104302.1  nuclear transcription factor Y subunit alpha isoform a

    See identical proteins and their annotated locations for NP_001104302.1

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS50142.1
    UniProtKB/TrEMBL
    Q8K2W1, Q9DBV7
    Related
    ENSMUSP00000043909.8, ENSMUST00000046719.14
    Conserved Domains (1) summary
    pfam02045
    Location:263 → 318
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

  2. NM_001347401.2 → NP_001334330.1  nuclear transcription factor Y subunit alpha isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS84321.1
    UniProtKB/Swiss-Prot
    P23708
    UniProtKB/TrEMBL
    Q8K2W1
    Related
    ENSMUSP00000077853.7, ENSMUST00000078800.13
    Conserved Domains (1) summary
    pfam02045
    Location:262 → 317
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

  3. NM_001347402.2 → NP_001334331.1  nuclear transcription factor Y subunit alpha isoform d

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS84320.1
    UniProtKB/TrEMBL
    A0A0R4J1Y8, Q8K2W1
    Related
    ENSMUSP00000124404.2, ENSMUST00000159063.8
    Conserved Domains (1) summary
    pfam02045
    Location:228 → 283
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

  4. NM_001374803.2 → NP_001361732.1  nuclear transcription factor Y subunit alpha isoform e

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS89116.1
    UniProtKB/TrEMBL
    E0CYF3, Q8K2W1
    Related
    ENSMUSP00000124245.2, ENSMUST00000160319.8
    Conserved Domains (1) summary
    pfam02045
    Location:257 → 312
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

  5. NM_001413334.1 → NP_001400263.1  nuclear transcription factor Y subunit alpha isoform h

    Status: VALIDATED

    Source sequence(s)
    AC166164

  6. NM_001413335.1 → NP_001400264.1  nuclear transcription factor Y subunit alpha isoform g

    Status: VALIDATED

    Source sequence(s)
    AC166164

  7. NM_001413336.1 → NP_001400265.1  nuclear transcription factor Y subunit alpha isoform f

    Status: VALIDATED

    Source sequence(s)
    AC166164

  8. NM_001413337.1 → NP_001400266.1  nuclear transcription factor Y subunit alpha isoform i

    Status: VALIDATED

    Source sequence(s)
    AC166164

  9. NM_001413338.1 → NP_001400267.1  nuclear transcription factor Y subunit alpha isoform j

    Status: VALIDATED

    Source sequence(s)
    AC166164

  10. NM_001413339.1 → NP_001400268.1  nuclear transcription factor Y subunit alpha isoform k

    Status: VALIDATED

    Source sequence(s)
    AC166164

  11. NM_001413340.1 → NP_001400269.1  nuclear transcription factor Y subunit alpha isoform l

    Status: VALIDATED

    Source sequence(s)
    AC166164

  12. NM_001413341.1 → NP_001400270.1  nuclear transcription factor Y subunit alpha isoform m

    Status: VALIDATED

    Source sequence(s)
    AC166164

  13. NM_001413342.1 → NP_001400271.1  nuclear transcription factor Y subunit alpha isoform n

    Status: VALIDATED

    Source sequence(s)
    AC166164

  14. NM_001413343.1 → NP_001400272.1  nuclear transcription factor Y subunit alpha isoform o

    Status: VALIDATED

    Source sequence(s)
    AC166164

  15. NM_001413344.1 → NP_001400273.1  nuclear transcription factor Y subunit alpha isoform p

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Related
    ENSMUSP00000124501.2, ENSMUST00000159535.2

  16. NM_010913.3 → NP_035043.1  nuclear transcription factor Y subunit alpha isoform b

    See identical proteins and their annotated locations for NP_035043.1

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS28867.1
    UniProtKB/TrEMBL
    Q3UP82, Q8K2W1
    Related
    ENSMUSP00000123785.2, ENSMUST00000162460.8
    Conserved Domains (1) summary
    pfam02045
    Location:234 → 289
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48693917..48716782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23708.2 GenPept UniProtKB/Swiss-Prot:P23708

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous