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Nbl1 NBL1, DAN family BMP antagonist [ Mus musculus (house mouse) ]

Gene ID: 17965, updated on 5-Mar-2024

Summary

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Official Symbol
Nbl1provided by MGI
Official Full Name
NBL1, DAN family BMP antagonistprovided by MGI
Primary source
MGI:MGI:104591
See related
Ensembl:ENSMUSG00000041120 AllianceGenome:MGI:104591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAN; NO3; Dana; D4H1S1733E
Summary
Enables BMP binding activity and morphogen activity. Involved in several processes, including determination of dorsal identity; negative regulation of monocyte chemotaxis; and sequestering of BMP in extracellular matrix. Acts upstream of or within negative regulation of BMP signaling pathway; neuron projection morphogenesis; and positive regulation of neuron differentiation. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain ventricular layer; embryo mesenchyme; limb; and nose. Orthologous to several human genes including MICOS10-NBL1 (MICOS10-NBL1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 159.8), lung adult (RPKM 140.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 70.57 cM; 4 D3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138809602..138820437, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139082291..139093126, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 4 Neighboring gene predicted gene, 33214 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 6 Neighboring gene STARR-positive B cell enhancer ABC_E4693 Neighboring gene mitochondrial contact site and cristae organizing system subunit 10 Neighboring gene STARR-positive B cell enhancer ABC_E9606 Neighboring gene predicted gene, 33304 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduced inflammatory pain in mice deficient in the differential screening-selected gene aberrative in neuroblastoma. Ohtori S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033178
  2. Expression of the BMP antagonist Dan during murine forebrain development. Kim AS, et al. Brain Res Dev Brain Res, 2003 Oct 10. PMID 14519502
  3. GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells. López de Maturana R, et al. Neuromolecular Med, 2007. PMID 17914181
  4. Cloning of mouse DAN cDNA and its down-regulation in transformed cells. Ozaki T, et al. Jpn J Cancer Res, 1996 Jan. PMID 8609050, Free PMC Article
  5. Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis. Shi W, et al. Am J Physiol Lung Cell Mol Physiol, 2001 May. PMID 11290528

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DAN is a novel autocrine/paracrine factor that modulates GnRH function in pituitary gonadotropes.
    Title: GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells.
  2. Dan expression during murine forebrain development from embryonic day 10.5 to postnatal day 14 and found that Dan was expressed in highly specific spatiotemporal patterns.
    Title: Expression of the BMP antagonist Dan during murine forebrain development.
  3. Data using DAN-deficient mice to investigate thermal and mechanical allodynia and Fos expression in the spinal dorsal horn suggest that Dan may be a neuromodulator in inflammatory pain.
    Title: Reduced inflammatory pain in mice deficient in the differential screening-selected gene aberrative in neuroblastoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC123430

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables BMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables morphogen activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sequestering of BMP from receptor via BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of BMP in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuroblastoma suppressor of tumorigenicity 1
Names
N03
neuroblastoma, suppression of tumorigenicity 1
zinc finger protein DAN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008675.2 → NP_032701.2  neuroblastoma suppressor of tumorigenicity 1 precursor

    See identical proteins and their annotated locations for NP_032701.2

    Status: VALIDATED

    Source sequence(s)
    AK146535
    Consensus CDS
    CCDS18839.1
    UniProtKB/Swiss-Prot
    Q499K5, Q61477
    Related
    ENSMUSP00000045608.7, ENSMUST00000042844.7
    Conserved Domains (1) summary
    pfam03045
    Location:22 → 120
    DAN; DAN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138809602..138820437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253300.1 → XP_030109160.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

    UniProtKB/Swiss-Prot
    Q499K5, Q61477
    Conserved Domains (1) summary
    pfam03045
    Location:22 → 120
    DAN; DAN domain

  2. XM_036163807.1 → XP_036019700.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

    Conserved Domains (1) summary
    pfam03045
    Location:71 → 169
    DAN; DAN domain

  3. XM_006538625.5 → XP_006538688.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

    See identical proteins and their annotated locations for XP_006538688.1

    UniProtKB/Swiss-Prot
    Q499K5, Q61477
    Conserved Domains (1) summary
    pfam03045
    Location:22 → 120
    DAN; DAN domain

  4. XM_030253299.2 → XP_030109159.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

    UniProtKB/Swiss-Prot
    Q499K5, Q61477
    Conserved Domains (1) summary
    pfam03045
    Location:22 → 120
    DAN; DAN domain

  5. XM_036163808.1 → XP_036019701.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

    UniProtKB/Swiss-Prot
    Q499K5, Q61477
    Conserved Domains (1) summary
    pfam03045
    Location:22 → 120
    DAN; DAN domain

  6. XM_030253301.2 → XP_030109161.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

    UniProtKB/Swiss-Prot
    Q499K5, Q61477
    Conserved Domains (1) summary
    pfam03045
    Location:22 → 120
    DAN; DAN domain

  7. XM_036163809.1 → XP_036019702.1  neuroblastoma suppressor of tumorigenicity 1 isoform X3

    Conserved Domains (1) summary
    pfam03045
    Location:57 → 155
    DAN; DAN domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61477.2 GenPept UniProtKB/Swiss-Prot:Q61477

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