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Myom2 myomesin 2 [ Mus musculus (house mouse) ]

Gene ID: 17930, updated on 3-Apr-2024

Summary

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Official Symbol
Myom2provided by MGI
Official Full Name
myomesin 2provided by MGI
Primary source
MGI:MGI:1328358
See related
Ensembl:ENSMUSG00000031461 AllianceGenome:MGI:1328358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin filament binding activity and kinase binding activity. Acts upstream of or within muscle contraction. Located in M band. Is expressed in several structures, including heart; limb; notochord; paraxial mesenchyme; and skeletal musculature. Orthologous to human MYOM2 (myomesin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 109.4), mammary gland adult (RPKM 11.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
8 A1.1; 8 7.63 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (15107653..15183410)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (15057653..15133420)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35340 Neighboring gene expressed sequence BB014433 Neighboring gene STARR-seq mESC enhancer starr_20806 Neighboring gene STARR-seq mESC enhancer starr_20807 Neighboring gene predicted gene, 24231 Neighboring gene predicted gene, 35392

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and expression of the gene encoding murine M-protein, a sarcomere-specific member of the immunoglobulin superfamily. Steiner F, et al. Genomics, 1998 Apr 1. PMID 9570952
  2. Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice. Carlsson L, et al. Exp Cell Res, 1999 Aug 25. PMID 10438587
  3. Establishment of cardiac cytoarchitecture in the developing mouse heart. Hirschy A, et al. Dev Biol, 2006 Jan 15. PMID 16337936
  4. Myomesin 3, a novel structural component of the M-band in striated muscle. Schoenauer R, et al. J Mol Biol, 2008 Feb 15. PMID 18177667
  5. Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. Hayashi S, et al. Elife, 2016 Oct 15. PMID 27743478, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141540, MGC141541

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
myomesin-2
Names
skeletal muscle 165kD protein
skeletal muscle 165kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414182.1 → NP_001401111.1  myomesin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235
    UniProtKB/TrEMBL
    Q14BI5

  2. NM_001414183.1 → NP_001401112.1  myomesin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235
    UniProtKB/TrEMBL
    Q14BI5

  3. NM_001414184.1 → NP_001401113.1  myomesin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235
    UniProtKB/TrEMBL
    Q14BI5

  4. NM_001414185.1 → NP_001401114.1  myomesin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235
    UniProtKB/TrEMBL
    Q14BI5

  5. NM_001414186.1 → NP_001401115.1  myomesin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235
    UniProtKB/TrEMBL
    Q14BI5

  6. NM_001414187.1 → NP_001401116.1  myomesin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235
    UniProtKB/TrEMBL
    Q14BI5

  7. NM_001414188.1 → NP_001401117.1  myomesin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235

  8. NM_001414189.1 → NP_001401118.1  myomesin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235

  9. NM_001414190.1 → NP_001401119.1  myomesin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235

  10. NM_008664.3 → NP_032690.2  myomesin-2 isoform 1

    See identical proteins and their annotated locations for NP_032690.2

    Status: VALIDATED

    Source sequence(s)
    AC124604, AC125235
    Consensus CDS
    CCDS22123.1
    UniProtKB/TrEMBL
    Q14BI5, Q3UQS9
    Related
    ENSMUSP00000033842.4, ENSMUST00000033842.4
    Conserved Domains (6) summary
    cd05891
    Location:1344 → 1435
    IgI_M-protein_C; C-terminal immunoglobulin (Ig)-like domain of M-protein; member of the I-set of Ig superfamily (IgSF) domains
    smart00409
    Location:940 → 995
    IG; Immunoglobulin
    cd00063
    Location:383 → 475
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:295 → 299
    Ig; Ig strand B [structural motif]
    cd20951
    Location:154 → 247
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:290 → 372
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    15107653..15183410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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