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Mxi1 MAX interactor 1, dimerization protein [ Mus musculus (house mouse) ]

Gene ID: 17859, updated on 5-Mar-2024

Summary

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Official Symbol
Mxi1provided by MGI
Official Full Name
MAX interactor 1, dimerization proteinprovided by MGI
Primary source
MGI:MGI:97245
See related
Ensembl:ENSMUSG00000025025 AllianceGenome:MGI:97245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mad2; Gm10197; bHLHc11
Summary
This gene encodes a protein containing a helix-loop-helix domain characteristic of transcription factors, which allows heterodimerization and sequence-specific DNA binding. The encoded protein is related to a family of Myc/Max/Mad proteins that are involved in the regulation of several cellular processes. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate Myc function. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine adult (RPKM 8.9), testis adult (RPKM 8.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mxi1 in Genome Data Viewer
Location:
19 D2; 19 47.53 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (53298509..53361724)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (53310128..53373293)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001K23 gene Neighboring gene predicted gene, 36339 Neighboring gene STARR-seq mESC enhancer starr_46442 Neighboring gene STARR-positive B cell enhancer ABC_E783 Neighboring gene predicted gene, 30541 Neighboring gene STARR-seq mESC enhancer starr_46448 Neighboring gene survival motor neuron domain containing 1 Neighboring gene VISTA enhancer mm1351 Neighboring gene STARR-positive B cell enhancer ABC_E4292 Neighboring gene STARR-positive B cell enhancer ABC_E1980 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53499127-53499376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53515061-53515299 Neighboring gene STARR-positive B cell enhancer ABC_E5711 Neighboring gene STARR-seq mESC enhancer starr_46454 Neighboring gene RIKEN cDNA 4833407H14 gene Neighboring gene STARR-seq mESC enhancer starr_46456 Neighboring gene myocardial infarction associated transcript 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivation of Mxi1 induces Il-8 secretion activation in polycystic kidney. Yoo KH, et al. Biochem Biophys Res Commun, 2007 Apr 27. PMID 17350592
  2. Max interacting protein 1 induces IL-17-producing T helper/regulatory T imbalance in osteoarthritis by upregulating tectonic family member 2. Li X, et al. Tissue Cell, 2022 Oct. PMID 36049372
  3. CXCL10 expression induced by Mxi1 inactivation induces mesangial cell apoptosis in mouse Habu nephritis. Wu L, et al. Cell Signal, 2015 May. PMID 25683914
  4. Inactivation of max-interacting protein 1 induces renal cilia disassembly through reduction in levels of intraflagellar transport 20 in polycystic kidney. Ko JY, et al. J Biol Chem, 2013 Mar 1. PMID 23316056, Free PMC Article
  5. Over-expression of Mxi1 represses renal epithelial tubulogenesis through the reduction of matrix metalloproteinase 9. Song SA, et al. Biochem Biophys Res Commun, 2012 Mar 16. PMID 22342670

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Max interacting protein 1 induces IL-17-producing T helper/regulatory T imbalance in osteoarthritis by upregulating tectonic family member 2.
    Title: Max interacting protein 1 induces IL-17-producing T helper/regulatory T imbalance in osteoarthritis by upregulating tectonic family member 2.
  2. The mesangial cell apoptosis observed in this mesangial proliferative glomerulonephritis model was related to CXCL10 expression induced by Mxi1 inactivation.
    Title: CXCL10 expression induced by Mxi1 inactivation induces mesangial cell apoptosis in mouse Habu nephritis.
  3. Mxi1 regulates Ift20 promoter activity via Ets-1 binding to the Ift20 promoter. These results indicate that inactivating Mxi1 induces ciliary defects in polycystic kidney.
    Title: Inactivation of max-interacting protein 1 induces renal cilia disassembly through reduction in levels of intraflagellar transport 20 in polycystic kidney.
  4. The results support the suggestion that over-expression of Mxi1 can suppress renal epithelial tubulogenesis.
    Title: Over-expression of Mxi1 represses renal epithelial tubulogenesis through the reduction of matrix metalloproteinase 9.
  5. The results support the suggestion that inactivation of Mxi1 has a positive effect on cell proliferation by down-regulating IGFBP-3.
    Title: Mxi1 regulates cell proliferation through insulin-like growth factor binding protein-3.
  6. down-regulation of miR-191 is essential for erythroid chromatin condensation and enucleation by allowing up-regulation of Riok3 and Mxi1
    Title: miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.
  7. Apolipoprotein A1 which is a major component of the high-density lipoprotein complex and has anti-inflammation effects, was significantly decreased in the Mxi1-deficient mouse.
    Title: Identification of apolipoproteinA1 reduction in the polycystic kidney by proteomics analysis of the Mxi1-deficient mouse.
  8. Mxi1-SRalpha is an isoform with enhanced transcriptional repression potential
    Title: Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
max-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008542.3 → NP_001008542.2  max-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_001008542.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also referred to as SRalpha, differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is longer and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC133451, BC064453
    Consensus CDS
    CCDS38022.1
    UniProtKB/TrEMBL
    Q3U3X2, Q6P2L3
    Related
    ENSMUSP00000003870.8, ENSMUST00000003870.15
    Conserved Domains (1) summary
    smart00353
    Location:140 → 192
    HLH; helix loop helix domain

  2. NM_001008543.3 → NP_001008543.1  max-interacting protein 1 isoform c

    See identical proteins and their annotated locations for NP_001008543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also referred to as WR, differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
    Source sequence(s)
    AC133451, L38821
    Consensus CDS
    CCDS38023.1
    UniProtKB/TrEMBL
    A0A494B9V1
    Related
    ENSMUSP00000158401.2, ENSMUST00000235201.2
    Conserved Domains (2) summary
    TIGR02169
    Location:75 → 155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32 → 111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins

  3. NM_001360345.1 → NP_001347274.1  max-interacting protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
    Source sequence(s)
    AC133451
    Consensus CDS
    CCDS38023.1
    UniProtKB/TrEMBL
    A0A494B9V1
    Related
    ENSMUSP00000025998.9, ENSMUST00000025998.15
    Conserved Domains (2) summary
    TIGR02169
    Location:75 → 155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32 → 111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins

  4. NM_001360346.1 → NP_001347275.1  max-interacting protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
    Source sequence(s)
    AC133451
    Consensus CDS
    CCDS38023.1
    UniProtKB/TrEMBL
    A0A494B9V1
    Conserved Domains (2) summary
    TIGR02169
    Location:75 → 155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32 → 111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins

  5. NM_001360347.1 → NP_001347276.1  max-interacting protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
    Source sequence(s)
    AC133451
    Consensus CDS
    CCDS38023.1
    UniProtKB/TrEMBL
    A0A494B9V1
    Related
    ENSMUSP00000157400.2, ENSMUST00000236973.2
    Conserved Domains (2) summary
    TIGR02169
    Location:75 → 155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32 → 111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins

  6. NM_001360348.1 → NP_001347277.1  max-interacting protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (d) is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC133451
    Conserved Domains (2) summary
    smart00353
    Location:80 → 132
    HLH; helix loop helix domain
    cl25732
    Location:118 → 198
    SMC_N; RecF/RecN/SMC N terminal domain

  7. NM_010847.4 → NP_034977.1  max-interacting protein 1 isoform a

    See identical proteins and their annotated locations for NP_034977.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also referred to as SRbeta, encodes the predominant isoform (a).
    Source sequence(s)
    AC133451, AK140465, CJ170779
    Consensus CDS
    CCDS29901.1
    UniProtKB/Swiss-Prot
    P50540
    UniProtKB/TrEMBL
    Q3USD3, Q6P2L3
    Related
    ENSMUSP00000107366.3, ENSMUST00000111737.3
    Conserved Domains (1) summary
    smart00353
    Location:73 → 125
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    53298509..53361724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526735.5 → XP_006526798.1  max-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    Q6P2L3
    Conserved Domains (2) summary
    TIGR02169
    Location:168 → 248
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl00081
    Location:125 → 204
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  2. XM_006526739.2 → XP_006526802.1  max-interacting protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006526802.1

    UniProtKB/TrEMBL
    A0A494B9V1
    Related
    ENSMUSP00000157822.2, ENSMUST00000237480.2
    Conserved Domains (2) summary
    TIGR02169
    Location:75 → 155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32 → 111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins

  3. XM_030250763.1 → XP_030106623.1  max-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A494B9V1
    Conserved Domains (2) summary
    PRK00286
    Location:10 → 186
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cl00081
    Location:58 → 137
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  4. XM_030250765.1 → XP_030106625.1  max-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A494B9V1
    Related
    ENSMUSP00000157790.2, ENSMUST00000235880.2
    Conserved Domains (2) summary
    TIGR02169
    Location:75 → 155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32 → 111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins

  5. XM_030250764.2 → XP_030106624.1  max-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A494B9V1
    Conserved Domains (2) summary
    TIGR02169
    Location:75 → 155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32 → 111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50540.1 GenPept UniProtKB/Swiss-Prot:P50540

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