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Map7 microtubule-associated protein 7 [ Mus musculus (house mouse) ]

Gene ID: 17761, updated on 11-Apr-2024

Summary

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Official Symbol
Map7provided by MGI
Official Full Name
microtubule-associated protein 7provided by MGI
Primary source
MGI:MGI:1328328
See related
Ensembl:ENSMUSG00000019996 AllianceGenome:MGI:1328328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ste; mshi; mste; MAP-7; Mtap7; E-MAP-115
Summary
Enables signaling receptor binding activity. Involved in protein localization to plasma membrane and response to osmotic stress. Acts upstream of or within several processes, including gamete generation; male gonad development; and response to retinoic acid. Located in plasma membrane. Is expressed in several structures, including alimentary system; endocrine gland; ganglia; genitourinary system; and skin. Orthologous to human MAP7 (microtubule associated protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 10.3), cortex adult (RPKM 7.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Map7 in Genome Data Viewer
Location:
10 A3; 10 9.75 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (20024666..20157336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (20148920..20281590)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25941 Neighboring gene STARR-seq mESC enhancer starr_25942 Neighboring gene peroxisomal biogenesis factor 7 Neighboring gene STARR-seq mESC enhancer starr_25943 Neighboring gene STARR-positive B cell enhancer ABC_E10597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19659120-19659310 Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene STARR-seq mESC enhancer starr_25945 Neighboring gene STARR-positive B cell enhancer mm9_chr10:19711687-19711987 Neighboring gene STARR-positive B cell enhancer ABC_E8326 Neighboring gene STARR-positive B cell enhancer ABC_E11432 Neighboring gene STARR-seq mESC enhancer starr_25946 Neighboring gene STARR-seq mESC enhancer starr_25947 Neighboring gene STARR-seq mESC enhancer starr_25949 Neighboring gene STARR-seq mESC enhancer starr_25952 Neighboring gene RIKEN cDNA 4930405J17 gene Neighboring gene predicted gene, 51795 Neighboring gene STARR-seq mESC enhancer starr_25958 Neighboring gene ribosomal protein L32-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19977636-19977875 Neighboring gene predicted gene, 48249 Neighboring gene predicted gene, 30285 Neighboring gene microRNA 6413

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MAP7 Prevents Axonal Branch Retraction by Creating a Stable Microtubule Boundary to Rescue Polymerization. Tymanskyj SR, et al. J Neurosci, 2019 Sep 4. PMID 31391261, Free PMC Article
  2. MAP7 regulates organelle transport by recruiting kinesin-1 to microtubules. Chaudhary AR, et al. J Biol Chem, 2019 Jun 28. PMID 31085585, Free PMC Article
  3. The H-mshi antigen is conserved among standard BALB/cBy, C57BL/6J, and wild-derived CAST/Ei and SPRET/Ei inbred strains of mice. Hildebrandt AL, et al. Immunogenetics, 1999 Jul. PMID 10369925
  4. The distribution of murine 115-kDa epithelial microtubule-associated protein (E-MAP-115) during embryogenesis and in adult organs suggests a role in epithelial polarization and differentiation. Fabre-Jonca N, et al. Differentiation, 1998 Aug. PMID 9745708
  5. MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon. Pan X, et al. Cell Rep, 2019 Feb 19. PMID 30784582, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAP7 binds to the acetylated and stable region of individual microtubules and rescues microtubule polymerization in developing sensory neurons.
    Title: MAP7 Prevents Axonal Branch Retraction by Creating a Stable Microtubule Boundary to Rescue Polymerization.
  2. MAP7D2 interacts with all three kinesin-1 family members and accumulates in the proximal axon through its N-terminal microtubule-binding domain. Depletion of MAP7D2 results in reduced axonal cargo entry.
    Title: MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon.
  3. MAP7 does not alter the force exerted by a single kinesin-1 motor, but instead increases its binding rate to the microtubule
    Title: MAP7 regulates organelle transport by recruiting kinesin-1 to microtubules.
  4. identification of the microtubule-associated protein ensconsin (Ens)/microtubule-associated protein 7 (MAP7) and kinesin heavy chain (Khc)/Kif5b as essential, evolutionarily conserved regulators of myonuclear positioning in Drosophila and cultured mammalian myotubes
    Title: MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function.
  5. Complementation testing showed that one of these, Mtap7, is disrupted in mshi mice.
    Title: The male sterility and histoincompatibility (mshi) mutation in mice is a natural variant of microtubule-associated protein 7 (Mtap7).
  6. MAP7 is the TRPV4 C-terminal binding protein; alignment of a.a.798-809 of TRPV4 was important in this interaction; TRPV4 and MAP7 colocalized in lung and kidney; coexpression resulted in redistribution of TRPV4 and enhanced membrane expression of TRPV4
    Title: Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).
Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description Tests
male sterility and histoincompatibility
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Leydig cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within Sertoli cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glycosphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ensconsin
Names
epithelial microtubule-associated protein of 115 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198635.2 → NP_001185564.1  ensconsin isoform 2

    See identical proteins and their annotated locations for NP_001185564.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) has an additional segment, as compared to isoform 1.
    Source sequence(s)
    AC153845, AC158620
    Consensus CDS
    CCDS56694.1
    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    UniProtKB/TrEMBL
    D3YWN7
    Related
    ENSMUSP00000111963.4, ENSMUST00000116259.5
    Conserved Domains (1) summary
    pfam05672
    Location:458 → 610
    MAP7; MAP7 (E-MAP-115) family

  2. NM_001358787.1 → NP_001345716.1  ensconsin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB098611, AK014575, BC052637, BY264190
    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (3) summary
    pfam03999
    Location:111 → 337
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam05672
    Location:472 → 625
    MAP7; MAP7 (E-MAP-115) family
    pfam09756
    Location:101 → 174
    DDRGK; DDRGK domain

  3. NM_001428647.1 → NP_001415576.1  ensconsin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620

  4. NM_001428648.1 → NP_001415577.1  ensconsin isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620

  5. NM_001428649.1 → NP_001415578.1  ensconsin isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620

  6. NM_001428650.1 → NP_001415579.1  ensconsin isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620

  7. NM_001428651.1 → NP_001415580.1  ensconsin isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620

  8. NM_001428652.1 → NP_001415581.1  ensconsin isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620

  9. NM_001428653.1 → NP_001415582.1  ensconsin isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620

  10. NM_001428654.1 → NP_001415583.1  ensconsin isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620

  11. NM_001428655.1 → NP_001415584.1  ensconsin isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620
    UniProtKB/TrEMBL
    A0A1L1SVB6

  12. NM_001428656.1 → NP_001415585.1  ensconsin isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC153845, AC158620

  13. NM_008635.3 → NP_032661.2  ensconsin isoform 1

    See identical proteins and their annotated locations for NP_032661.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the dominant transcript and encodes isoform 1.
    Source sequence(s)
    AC153845, AC158620
    Consensus CDS
    CCDS87968.1
    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    UniProtKB/TrEMBL
    E9QMU3
    Related
    ENSMUSP00000020173.10, ENSMUST00000020173.16
    Conserved Domains (1) summary
    pfam05672
    Location:450 → 602
    MAP7; MAP7 (E-MAP-115) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    20024666..20157336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155666.1 → XP_036011559.1  ensconsin isoform X8

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (1) summary
    pfam05672
    Location:312 → 464
    MAP7; MAP7 (E-MAP-115) family

  2. XM_006512577.4 → XP_006512640.1  ensconsin isoform X1

    Conserved Domains (2) summary
    pfam05672
    Location:480 → 632
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:111 → 180
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  3. XM_036155665.1 → XP_036011558.1  ensconsin isoform X4

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:442 → 594
    MAP7; MAP7 (E-MAP-115) family
    pfam06098
    Location:111 → 168
    Radial_spoke_3; Radial spoke protein 3

  4. XM_006512582.4 → XP_006512645.1  ensconsin isoform X6

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:434 → 586
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:111 → 180
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  5. XM_036155667.1 → XP_036011560.1  ensconsin isoform X9

    Conserved Domains (1) summary
    pfam05672
    Location:274 → 426
    MAP7; MAP7 (E-MAP-115) family

  6. XM_006512584.5 → XP_006512647.1  ensconsin isoform X8

    Conserved Domains (1) summary
    pfam05672
    Location:312 → 464
    MAP7; MAP7 (E-MAP-115) family

  7. XM_006512585.5 → XP_006512648.1  ensconsin isoform X8

    See identical proteins and their annotated locations for XP_006512648.1

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (1) summary
    pfam05672
    Location:312 → 464
    MAP7; MAP7 (E-MAP-115) family

  8. XM_006512580.3 → XP_006512643.1  ensconsin isoform X3

    Conserved Domains (2) summary
    pfam05672
    Location:443 → 595
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:74 → 145
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  9. XM_006512581.3 → XP_006512644.1  ensconsin isoform X5

    Conserved Domains (2) summary
    pfam05672
    Location:435 → 587
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:74 → 143
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  10. XM_006512583.4 → XP_006512646.1  ensconsin isoform X7

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:421 → 573
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:98 → 167
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  11. XM_006512579.4 → XP_006512642.1  ensconsin isoform X2

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:467 → 619
    MAP7; MAP7 (E-MAP-115) family
    pfam09756
    Location:88 → 161
    DDRGK; DDRGK domain

  12. XM_036155668.1 → XP_036011561.1  ensconsin isoform X10

    Conserved Domains (1) summary
    pfam05672
    Location:193 → 345
    MAP7; MAP7 (E-MAP-115) family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001198636.1: Suppressed sequence

    Description
    NM_001198636.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88735.1 GenPept UniProtKB/Swiss-Prot:O88735

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