Mt2 metallothionein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mt2provided by MGI
Official Full Name: metallothionein 2provided by MGI
Primary source: MGI:MGI:97172
See related: Ensembl:ENSMUSG00000031762 AllianceGenome:MGI:97172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mt-2; MT-II
Summary: Predicted to enable cadmium ion binding activity and zinc ion binding activity. Acts upstream of or within several processes, including cellular zinc ion homeostasis; detoxification of copper ion; and nitric oxide mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; liver lobe; lung; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in carotid stenosis and type 2 diabetes mellitus. Orthologous to several human genes including MT1X (metallothionein 1X). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14.5 (RPKM 757.6), liver E14 (RPKM 674.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 46.32 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (94899246..94900195)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94172618..94173567)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess.
Title: Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess.
Cardiac-specific overexpression of metallothionein attenuates L-NAME-induced myocardial contractile anomalies and apoptosis.
Title: Cardiac-specific overexpression of metallothionein attenuates L-NAME-induced myocardial contractile anomalies and apoptosis.
Cuprizone-induced demyelination is followed by high upregulation of MT-I/II and megalin immunoreactivity in astrocytes and epithelial and endothelial cells located in cerebral and cerebellar white and gray matter, as well as in choroid plexus and in numerous constituents of the neurogenic niches in subgranular zone (SGZ) of DG and in SVZ of lateral ventricles.
Title: Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination.
these results demonstrate that MT2 plays a role in CD4+ T cell activation by transducing reactive oxygen species signals into an increased [Zn2+]i that subsequently affects downstream effector function
Title: Metallothionein regulates intracellular zinc signaling during CD4(+) T cell activation.
blockade of metallothioneins 1 and 2 constitutes a promising approach for the treatment of conditions which result in muscle atrophy.
Title: Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength.
Cardioprotective effects of MT1/2 seem to be exerted via modulation of contractile elements, antioxidative enzymes, inflammatory response, and myocardial remodeling.
Title: Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice.
Metallothioneins may have a protective role against post-burn inflammation and inflammatory organ damage, at least partly through inhibiting the p38 MAPK signaling.
Title: Role of Metallothionein in Post-Burn Inflammation.
Enhanced senescence due to absence of metallothionein genes may shorten lifespan.
Title: Deficiency of metallothionein-1 and -2 genes shortens the lifespan of the 129/Sv mouse strain.
The MT2 receptor activates Akt/GSK-3beta/CRMP-2 signaling and is necessary and sufficient to mediate functional axonogenesis and synaptic formation in central neurons.
Title: The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling.
MT1/2 deficiency aggravated depleted uruanium-induced nephrotoxicity, and the molecular mechanisms appeared to be related to the increased oxidative stress and apoptosis, and decreased SGLT expression.
Title: Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Mit15 (e-PCR), detects polymorphism
- UniSTS:131354

Mt2 (e-PCR), detects polymorphism
- UniSTS:143923

PMC99995P2 (e-PCR)
- UniSTS:273716

Mt2 (e-PCR), detects polymorphism
- UniSTS:143924

RH126542 (e-PCR)
- UniSTS:208317

Mt2 (e-PCR), detects polymorphism
- UniSTS:495838

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cadmium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detoxification of copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nitric oxide mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metallothionein-2

Names: metallothionein-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.