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atg-3 Ubiquitin-like-conjugating enzyme ATG3 [ Caenorhabditis elegans ]

Gene ID: 176921, updated on 5-May-2024

Summary

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Gene symbol
atg-3
Gene description
Ubiquitin-like-conjugating enzyme ATG3
Primary source
WormBase:WBGene00021922
Locus tag
CELE_Y55F3AM.4
See related
AllianceGenome:WB:WBGene00021922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Atg8 ligase activity. Involved in macroautophagy. Predicted to be part of cytoplasmic ubiquitin ligase complex. Predicted to be active in cytosol. Is expressed in body wall musculature; pharynx; reproductive system; and seam cell. Orthologous to human ATG3 (autophagy related 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (1010512..1012502)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SPIN90/Ldb17 leucine-rich domain-containing protein Neighboring gene Mitochondrial inner membrane protease subunit 2;Peptidase S26 domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene RRM domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Small differences make a big impact: Structural insights into the differential function of the 2 Atg8 homologs in C. elegans. Wu F, et al. Autophagy, 2016. PMID 27046254, Free PMC Article
  2. Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development. Huang S, et al. Autophagy, 2013 Feb 1. PMID 23108454, Free PMC Article
  3. C. elegans screen identifies autophagy genes specific to multicellular organisms. Tian Y, et al. Cell, 2010 Jun 11. PMID 20550938
  4. The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery. Lin L, et al. J Cell Biol, 2013 Apr 1. PMID 23530068, Free PMC Article
  5. Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Wu F, et al. Mol Cell, 2015 Dec 17. PMID 26687600

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Atg8-family ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Atg8-family ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ubiquitin-like-conjugating enzyme ATG3
NP_001368247.1
  • Confirmed by transcript evidence
NP_500024.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1010512..1012502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067623.7 → NP_500024.1  Ubiquitin-like-conjugating enzyme ATG3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500024.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N369
    Conserved Domains (3) summary
    pfam03986
    Location:8 → 120
    Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
    pfam03987
    Location:196 → 256
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    pfam10381
    Location:277 → 300
    Autophagy_C; Autophagocytosis associated protein C-terminal

  2. NM_001380030.1 → NP_001368247.1  Ubiquitin-like-conjugating enzyme ATG3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRD2
    Conserved Domains (1) summary
    pfam03987
    Location:2 → 90
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
Nucleotide Protein
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