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lin-9 Protein lin-9 [ Caenorhabditis elegans ]

Gene ID: 176256, updated on 25-Apr-2024

Summary

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Gene symbol
lin-9
Gene description
Protein lin-9
Primary source
WormBase:WBGene00002998
Locus tag
CELE_ZK637.7
See related
AllianceGenome:WB:WBGene00002998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Involved in several processes, including male sex differentiation; negative regulation of vulval development; and regulation of neurogenesis. Part of DRM complex. Orthologous to human LIN9 (lin-9 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (8900237..8904131, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene V-type proton ATPase 116 kDa subunit a 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene structure and molecular analysis of Arabidopsis thaliana ALWAYS EARLY homologs. Bhatt AM, et al. Gene, 2004 Jul 21. PMID 15246533
  2. The C. elegans genome sequencing project: a beginning. Sulston J, et al. Nature, 1992 Mar 5. PMID 1538779
  3. The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein. Beitel GJ, et al. Gene, 2000 Aug 22. PMID 10974557
  4. A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. Lee J, et al. Elife, 2019 Aug 6. PMID 31386623, Free PMC Article
  5. Reevaluation of whether a soma-to-germ-line transformation extends lifespan in Caenorhabditis elegans. Knutson AK, et al. Proc Natl Acad Sci U S A, 2016 Mar 29. PMID 26976573, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reproductive process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DRM complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription repressor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein lin-9
NP_001023015.1
  • Confirmed by transcript evidence
NP_001023016.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8900237..8904131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027844.5 → NP_001023015.1  Protein lin-9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023015.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30630
    Conserved Domains (1) summary
    pfam06584
    Location:224 → 330
    DIRP; DIRP

  2. NM_001027845.6 → NP_001023016.1  Protein lin-9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023016.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30630, Q9NB37, Q9NB38
    Conserved Domains (1) summary
    pfam06584
    Location:226 → 332
    DIRP; DIRP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30630.3

Gene LinkOut

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