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snx-14 Sorting nexin-12 [ Caenorhabditis elegans ]

Gene ID: 174997, updated on 23-Nov-2023

Summary

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Gene symbol
snx-14
Gene description
Sorting nexin-12
Primary source
WormBase:WBGene00013011
Locus tag
CELE_Y48E1B.14
See related
AllianceGenome:WB:WBGene00013011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in autophagosome maturation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in late endosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX14 (sorting nexin 14). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See snx-14 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (13522939..13531218, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Peptidase_M13_N domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class epsilon-45 Neighboring gene ncRNA Neighboring gene G domain-containing protein Neighboring gene PIG-P domain-containing protein Neighboring gene WASH complex subunit homolog 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sorting nexin-12
NP_496844.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13522939..13531218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064443.6 → NP_496844.3  Sorting nexin-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496844.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF63
    Conserved Domains (4) summary
    cd06877
    Location:591 → 708
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    smart00315
    Location:352 → 475
    RGS; Regulator of G protein signalling domain
    pfam08628
    Location:856 → 941
    Nexin_C; Sorting nexin C terminal
    cl02564
    Location:112 → 314
    PXA; PXA domain
Nucleotide Protein
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