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Mobp myelin-associated oligodendrocytic basic protein [ Mus musculus (house mouse) ]

Gene ID: 17433, updated on 5-Mar-2024

Summary

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Official Symbol
Mobpprovided by MGI
Official Full Name
myelin-associated oligodendrocytic basic proteinprovided by MGI
Primary source
MGI:MGI:108511
See related
Ensembl:ENSMUSG00000032517 AllianceGenome:MGI:108511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOBP69; MOBP73; MOBP81; MOBP155; MOBP170
Summary
A structural constituent of myelin sheath. Located in mitochondrion. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in frontotemporal dementia. Orthologous to human MOBP (myelin associated oligodendrocyte basic protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 138.0), cortex adult (RPKM 97.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
9 F4; 9 71.41 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119978740..120010554)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120149742..120181488)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 62 Neighboring gene ribosomal protein SA Neighboring gene predicted gene 5922 Neighboring gene STARR-seq mESC enhancer starr_25493 Neighboring gene predicted gene, 38642 Neighboring gene predicted gene, 47059

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Yool D, et al. Glia, 2002 Sep. PMID 12203392
  2. Splicing pattern, transcript start distribution, and DNA sequence of the mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein. McCallion AS, et al. Mol Cell Neurosci, 1999 Apr. PMID 10328883
  3. Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin. Yamamoto Y, et al. Eur J Neurosci, 1999 Mar. PMID 10103078
  4. Characterization of the murine splice variant Mobp155: developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Montague P, et al. Glia, 2005 Apr 1. PMID 15625715
  5. Morphometric analysis of the myelin-associated oligodendrocytic basic protein-deficient mouse reveals a possible role for myelin-associated oligodendrocytic basic protein in regulating axonal diameter. Sadahiro S, et al. Neuroscience, 2000. PMID 10854769

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MOBP synthesis is stimulated by Fyn activity.
    Title: MOBP levels are regulated by Fyn kinase and affect the morphological differentiation of oligodendrocytes.
  2. Mobp is associated with the alcohol-preference genotype in the context of alcohol-preferring, compared to alcohol-avoiding mouse strains.
    Title: Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice.
  3. MOBP-deficient mice develop normally, generate intact compact CNS myelin, and demonstrate no obvious clinical phenotype; absence of MOBP is not simply compensated for by increased expression of the "classic" myelin basic protein (MBP).
    Title: Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform.
  4. Although the Mobp155 and Mobp170 isoforms encode a common predicted C-terminus they have different expression profiles and their products are targeted to mitochondria and the nucleus, respectively, in transiently transfected Cos7 cells.
    Title: Characterization of the murine splice variant Mobp155: developmental CNS expression pattern and subcellular localization of epitope-tagged protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of myelin sheath ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath HDA PubMed 

General protein information

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Preferred Names
myelin-associated oligodendrocyte basic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039365.3 → NP_001034454.1  myelin-associated oligodendrocyte basic protein isoform b

    See identical proteins and their annotated locations for NP_001034454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform b) is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI839250, AK140055
    Consensus CDS
    CCDS23626.1
    UniProtKB/Swiss-Prot
    O35713, Q792D7, Q792D8, Q9D2P8, Q9JLY4, Q9JLY5, Q9JLY6
    Related
    ENSMUSP00000071084.8, ENSMUST00000068698.15
    Conserved Domains (2) summary
    PTZ00449
    Location:79 → 165
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  2. NM_008614.3 → NP_032640.1  myelin-associated oligodendrocyte basic protein isoform a

    See identical proteins and their annotated locations for NP_032640.1

    Status: VALIDATED

    Source sequence(s)
    AK028057, BX630280
    Consensus CDS
    CCDS40808.1
    UniProtKB/Swiss-Prot
    Q9D2P8
    Related
    ENSMUSP00000091287.2, ENSMUST00000093773.8
    Conserved Domains (1) summary
    cl22851
    Location:1 → 67
    PHD_SF; PHD finger superfamily

RNA

  1. NR_153958.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK083103, CD776657

  2. NR_153959.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC110091

  3. NR_153960.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC110091

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119978740..120010554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004935332.1 RNA Sequence

  2. XR_004935333.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039364.2: Suppressed sequence

    Description
    NM_001039364.2: This RefSeq has been removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2P8.1 GenPept UniProtKB/Swiss-Prot:Q9D2P8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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