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ntl-2 NOT2/NOT3/NOT5 C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173773, updated on 15-Oct-2023

Summary

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Gene symbol
ntl-2
Gene description
NOT2/NOT3/NOT5 C-terminal domain-containing protein
Primary source
WormBase:WBGene00003825
Locus tag
CELE_B0286.4
See related
AllianceGenome:WB:WBGene00003825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening and regulation of stem cell population maintenance. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including hypodermis; intestine; nervous system; rectal gland cell; and reproductive system. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (4372739..4376458, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Peptidase S1 domain-containing protein Neighboring gene Phosphoribosylaminoimidazole-succinocarboxamide synthase Neighboring gene miscRNA Neighboring gene Uncharacterized protein Neighboring gene Forkhead transcription factor fkh-6 Neighboring gene Peroxidase mlt-7 light chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Kuzuoglu-Öztürk D, et al. Nucleic Acids Res, 2012 Jul. PMID 22402495, Free PMC Article
  2. The Caenorhabditis elegans Argonautes ALG-1 and ALG-2: almost identical yet different. Tops BB, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381296
  3. The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans. Nousch M, et al. J Cell Sci, 2013 Sep 15. PMID 23843623
  4. The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Rocheleau CE, et al. Genetics, 2008 Mar. PMID 18245826, Free PMC Article
  5. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT core complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NOT2/NOT3/NOT5 C-terminal domain-containing protein
NP_001040726.1
  • Confirmed by transcript evidence
NP_001379564.1
  • Confirmed by transcript evidence
NP_494772.1
  • Confirmed by transcript evidence
NP_494773.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4372739..4376458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393050.1 → NP_001379564.1  NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95QZ3
    Conserved Domains (1) summary
    pfam04153
    Location:101 → 221
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  2. NM_062372.6 → NP_494773.1  NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494773.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95QZ4
    Conserved Domains (1) summary
    pfam04153
    Location:150 → 271
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  3. NM_062371.6 → NP_494772.1  NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q10923
    Conserved Domains (1) summary
    pfam04153
    Location:227 → 348
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  4. NM_001047261.5 → NP_001040726.1  NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040726.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2MZA9
    Conserved Domains (1) summary
    pfam04153
    Location:141 → 262
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
Nucleotide Protein
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