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Clec10a C-type lectin domain family 10, member A [ Mus musculus (house mouse) ]

Gene ID: 17312, updated on 27-Feb-2024

Summary

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Official Symbol
Clec10aprovided by MGI
Official Full Name
C-type lectin domain family 10, member Aprovided by MGI
Primary source
MGI:MGI:96975
See related
Ensembl:ENSMUSG00000000318 AllianceGenome:MGI:96975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mgl; Mgl1; CD301a; M-ASGP-BP-1
Summary
Predicted to enable carbohydrate binding activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including cartilage; dermis; embryo mesenchyme; metencephalon part of 4th ventricle choroid plexus; and spinal cord marginal layer. Orthologous to human CLEC10A (C-type lectin domain containing 10A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 20.4), bladder adult (RPKM 15.0) and 9 other tissues See more
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Genomic context

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Location:
11 B3; 11 42.99 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70057449..70061662)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70166623..70170836)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene asialoglycoprotein receptor 2 Neighboring gene predicted gene 12311 Neighboring gene macrophage galactose N-acetyl-galactosamine specific lectin 2 Neighboring gene STARR-seq mESC enhancer starr_29870 Neighboring gene STARR-seq mESC enhancer starr_29871 Neighboring gene STARR-seq mESC enhancer starr_29872 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 11 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel Role for Macrophage Galactose-Type Lectin-1 to Regulate Innate Immunity against Mycobacterium tuberculosis. Naqvi KF, et al. J Immunol, 2021 Jul 1. PMID 34183369, Free PMC Article
  2. CD301 mediates fusion in IL-4-driven multinucleated giant cell formation. Brooks PJ, et al. J Cell Sci, 2020 Dec 23. PMID 33571108
  3. MGL1 Receptor Plays a Key Role in the Control of T. cruzi Infection by Increasing Macrophage Activation through Modulation of ERK1/2, c-Jun, NF-κB and NLRP3 Pathways. Rodriguez T, et al. Cells, 2020 Jan 1. PMID 31906385, Free PMC Article
  4. Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation. Ilarregui JM, et al. J Neuroinflammation, 2019 Jun 27. PMID 31248427, Free PMC Article
  5. Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia. Jondle CN, et al. J Immunol, 2016 Apr 1. PMID 26912318, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report.
    Title: Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report.
  2. Intestinal lamina propria macrophages upregulate interleukin-10 mRNA in response to signals from commensal bacteria recognized by MGL1/CD301a.
    Title: Intestinal lamina propria macrophages upregulate interleukin-10 mRNA in response to signals from commensal bacteria recognized by MGL1/CD301a.
  3. CD301 mediates fusion in IL-4-driven multinucleated giant cell formation.
    Title: CD301 mediates fusion in IL-4-driven multinucleated giant cell formation.
  4. MGL1 Receptor Plays a Key Role in the Control of T. cruzi Infection by Increasing Macrophage Activation through Modulation of ERK1/2, c-Jun, NF-kappaB and NLRP3 Pathways.
    Title: MGL1 Receptor Plays a Key Role in the Control of T. cruzi Infection by Increasing Macrophage Activation through Modulation of ERK1/2, c-Jun, NF-κB and NLRP3 Pathways.
  5. Our findings suggest that Clec10a in mice and Asgr1 in humans play an important role in skin homeostasis against inflammation associated with house dust mite-induced dermatitis.
    Title: Clec10a regulates mite-induced dermatitis.
  6. Loss of Mgl1 expression is associated with enhanced alpha2-3Neu-von Willebrand factor clearance.
    Title: A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance.
  7. Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia
    Title: Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia.
  8. Mgl1-deficient mice displayed accelerated colonic propulsion and were hypersensitive to mu receptor-mediated inhibition of colonic motility.
    Title: Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity.
  9. MGL1 is involved in T. crassiceps recognition and subsequent innate immune activation and resistance.
    Title: The macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection.
  10. The MGL1 functions as an attachment and entry receptor for influenza A virus.
    Title: The macrophage galactose-type lectin can function as an attachment and entry receptor for influenza virus.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables fucose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological process involved in interspecies interaction between organisms IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-type lectin domain family 10 member A
Names
macrophage asialoglycoprotein-binding protein 1
macrophage galactose N-acetyl-galactosamine specific lectin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204252.1 → NP_001191181.1  C-type lectin domain family 10 member A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL669869
    Consensus CDS
    CCDS56784.1
    UniProtKB/TrEMBL
    F8WHB7, Q3TCD3
    Related
    ENSMUSP00000000327.7, ENSMUST00000000327.13
    Conserved Domains (2) summary
    cd03590
    Location:174 → 299
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:14 → 164
    Lectin_N; Hepatic lectin, N-terminal domain

  2. NM_010796.3 → NP_034926.1  C-type lectin domain family 10 member A isoform 2

    See identical proteins and their annotated locations for NP_034926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL669869
    Consensus CDS
    CCDS24936.1
    UniProtKB/Swiss-Prot
    P49300, Q549F6, Q91YT3
    UniProtKB/TrEMBL
    Q3TCD3
    Related
    ENSMUSP00000099631.4, ENSMUST00000102571.10
    Conserved Domains (2) summary
    cd03590
    Location:173 → 298
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:16 → 163
    Lectin_N; Hepatic lectin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70057449..70061662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49300.1 GenPept UniProtKB/Swiss-Prot:P49300

Gene LinkOut

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