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Kitl kit ligand [ Mus musculus (house mouse) ]

Gene ID: 17311, updated on 7-Apr-2024

Summary

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Official Symbol
Kitlprovided by MGI
Official Full Name
kit ligandprovided by MGI
Primary source
MGI:MGI:96974
See related
Ensembl:ENSMUSG00000019966 AllianceGenome:MGI:96974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted
Summary
Enables cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in extracellular space and plasma membrane. Is integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 2.7), CNS E18 (RPKM 2.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Kitl in Genome Data Viewer
Location:
10 D1; 10 51.4 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (99851477..99936278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (100015615..100100416)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35437 Neighboring gene keratin 18 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27731 Neighboring gene STARR-seq mESC enhancer starr_27732 Neighboring gene predicted gene, 35533 Neighboring gene STARR-seq mESC enhancer starr_27733 Neighboring gene STARR-seq mESC enhancer starr_27734 Neighboring gene THO complex 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair. Garcia-Hernandez V, et al. Inflamm Bowel Dis, 2023 Jul 5. PMID 36688460, Free PMC Article
  2. KIT ligand protects against both light-induced and genetic photoreceptor degeneration. Li H, et al. Elife, 2020 Apr 3. PMID 32242818, Free PMC Article
  3. Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion. Buono M, et al. Nat Commun, 2018 Nov 8. PMID 30410062, Free PMC Article
  4. Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis. Azzoni E, et al. EMBO Rep, 2018 Oct. PMID 30166337, Free PMC Article
  5. Identification of hair shaft progenitors that create a niche for hair pigmentation. Liao CP, et al. Genes Dev, 2017 Apr 15. PMID 28465357, Free PMC Article

See all (524) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells.
    Title: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells.
  2. Postnatal Expression of Kitl Affects Pigmentation of the Epidermis.
    Title: Postnatal Expression of Kitl Affects Pigmentation of the Epidermis.
  3. SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment.
    Title: SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment.
  4. Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair.
    Title: Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair.
  5. Sertoli cells are the source of stem cell factor for spermatogenesis.
    Title: Sertoli cells are the source of stem cell factor for spermatogenesis.
  6. KIT ligand produced by limbal niche cells under control of SOX10 maintains limbal epithelial stem cell survival by activating the KIT/AKT signalling pathway.
    Title: KIT ligand produced by limbal niche cells under control of SOX10 maintains limbal epithelial stem cell survival by activating the KIT/AKT signalling pathway.
  7. KIT ligand protects against both light-induced and genetic photoreceptor degeneration.
    Title: KIT ligand protects against both light-induced and genetic photoreceptor degeneration.
  8. adipoq, kitl and osx1 may have a role with regulation of hematopoietic stem and progenitor cells and myeloid progenitors
    Title: Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
  9. Cholangiocytes, but not hepatocytes, from stem cell factor (SCF) Mismatch Mdr2(-/-) mice have increased SCF expression and secretion. Inhibition of SCF in Mdr2(-/-) mice reduced (i) hepatic damage; (ii) mast cell migration; (iii) histamine and SCF serum levels.
    Title: Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2(-/-) mice.
  10. data point to transcription factor NRF2 as a major mediator of oxidized palmitoyl-arachidonoyl-phosphatidylcholine -induced upregulation of SCF. This mechanism may represent one of the facets of pleiotropic action of NRF2 in vascular wall.
    Title: Oxidized phospholipids stimulate production of stem cell factor via NRF2-dependent mechanisms.
Submit: New GeneRIF Correction See all GeneRIFs (126)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables stem cell factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables stem cell factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within germ cell development TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of mast cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of mast cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of mast cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of mast cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within melanocyte migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of myeloid leukocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of mast cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neural crest cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of MAP kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of leukocyte migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mast cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mast cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of melanocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of myeloid leukocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kit ligand
Names
C-kit ligand
Steel factor
cloud gray
grizzle-belly
hematopoietic growth factor KL
mast cell growth factor
stem cell factor
NP_001334085.1
NP_038626.1
XP_006513377.1
XP_006513378.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347156.2 → NP_001334085.1  kit ligand isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct internal amino acid and is shorter than isoform 1.
    Source sequence(s)
    AC159910
    Consensus CDS
    CCDS83751.1
    UniProtKB/Swiss-Prot
    P20826
    Related
    ENSMUSP00000020129.8, ENSMUST00000020129.8

  2. NM_001428623.1 → NP_001415552.1  kit ligand isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159910

  3. NM_001428627.1 → NP_001415556.1  kit ligand isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159910

  4. NM_013598.4 → NP_038626.1  kit ligand isoform 1 precursor

    See identical proteins and their annotated locations for NP_038626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC159910
    Consensus CDS
    CCDS36046.1
    UniProtKB/Swiss-Prot
    P20826, P97332, Q3TNJ7, Q62524, Q64222, Q921N5
    Related
    ENSMUSP00000100920.2, ENSMUST00000105283.9
    Conserved Domains (1) summary
    pfam02404
    Location:1 → 273
    SCF; Stem cell factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    99851477..99936278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513314.5 → XP_006513377.1  kit ligand isoform X1

    Conserved Domains (1) summary
    pfam02404
    Location:46 → 313
    SCF; Stem cell factor

  2. XM_006513315.4 → XP_006513378.1  kit ligand isoform X2

    Conserved Domains (1) summary
    pfam02404
    Location:46 → 285
    SCF; Stem cell factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20826.1 GenPept UniProtKB/Swiss-Prot:P20826

Gene LinkOut

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