Mep1a meprin 1 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mep1aprovided by MGI
Official Full Name: meprin 1 alphaprovided by MGI
Primary source: MGI:MGI:96963
See related: Ensembl:ENSMUSG00000023914 AllianceGenome:MGI:96963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mep1; Mep-1; Mep-1a
Summary: Predicted to enable metalloendopeptidase activity. Located in membrane. Is expressed in several structures, including gut and metanephros. Orthologous to human MEP1A (meprin A subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 196.4), large intestine adult (RPKM 119.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3; 17 19.73 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (43785215..43815034, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (43474324..43504143, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.
Title: Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.
Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation.
Title: Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation.
this study shows that docking of meprin alpha to heparan sulphate protects the endothelium from inflammatory cell extravasation
Title: Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation.
no significant dentin malformation was observed in Mep1b (-/-) or Mep1a (-/-) deficient mice.
Title: Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice.
meprin alpha and meprin beta join the modulators of Reelin signalling as they cleave Reelin at a specific site and are upregulated under specific pathological conditions.
Title: Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage.
While meprin A only cleaved protein kinase A (PKA) catalytic subunit beta1, meprin B cleaved all three PKA catalytic isoforms.
Title: Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury.
meprin alpha and meprin beta are unique in their ability to process and release both C- and N-propeptides from type I procollagen in vitro and in vivo
Title: Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength.
the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock
Title: Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney.
Absence of meprin A aggravates chronic inflammation and lack of meprin B affords some protection from injury. Manipulation of expression of meprin gene products may have therapeutic potential.
Title: Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.
MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.
Title: MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW107200 (e-PCR)
- UniSTS:181021

AI098089 (e-PCR)
- UniSTS:160662

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epidermal growth factor receptor ligand maturation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in signaling receptor ligand precursor processing	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of meprin A complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: meprin A subunit alpha

Names: endopeptidase-2; meprin A alpha-subunit; meprin alpha

NP_032611.2

EC 3.4.24.18

XP_006523814.1

EC 3.4.24.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008585.3 → NP_032611.2 meprin A subunit alpha precursor

See identical proteins and their annotated locations for NP_032611.2

Status: VALIDATED

Source sequence(s)

CT010585

Consensus CDS

CCDS37623.1

UniProtKB/Swiss-Prot

B0V2P9, P28825, Q91WH9

UniProtKB/TrEMBL

A0A0R4J043

Related

ENSMUSP00000024707.9, ENSMUST00000024707.9

Conserved Domains (4) summary

pfam00008
Location:688 → 722

EGF; EGF-like domain

cl02446
Location:443 → 607

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

pfam00629
Location:281 → 444

MAM; MAM domain, meprin/A5/mu

cl00064
Location:46 → 271

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

43785215..43815034 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523751.4 → XP_006523814.1 meprin A subunit alpha isoform X1

See identical proteins and their annotated locations for XP_006523814.1

UniProtKB/Swiss-Prot

B0V2P9, P28825, Q91WH9

UniProtKB/TrEMBL

A0A0R4J043

Conserved Domains (4) summary

pfam00008
Location:688 → 722

EGF; EGF-like domain

cl02446
Location:443 → 607

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

pfam00629
Location:281 → 444

MAM; MAM domain, meprin/A5/mu

cl00064
Location:46 → 271

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...