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Anapc1 anaphase promoting complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 17222, updated on 5-Mar-2024

Summary

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Official Symbol
Anapc1provided by MGI
Official Full Name
anaphase promoting complex subunit 1provided by MGI
Primary source
MGI:MGI:103097
See related
Ensembl:ENSMUSG00000014355 AllianceGenome:MGI:103097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apc1; Mcpr; tsg24; 2610021O03Rik
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Located in nucleus. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.6), limb E14.5 (RPKM 12.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 62.63 cM
Exon count:
50
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128452003..128529558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128610083..128687406, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family, member E4C Neighboring gene predicted gene, 39929 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4498 Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene MER proto-oncogene tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_05650 Neighboring gene STARR-seq mESC enhancer starr_05651 Neighboring gene STARR-positive B cell enhancer ABC_E2046 Neighboring gene transmembrane protein 87B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel murine gene encoding a 216-kDa protein is related to a mitotic checkpoint regulator previously identified in Aspergillus nidulans. Starborg M, et al. J Biol Chem, 1994 Sep 30. PMID 7929068
  2. Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I. Davis ES, et al. Genetics, 2002 Feb. PMID 11861581, Free PMC Article
  3. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Jörgensen PM, et al. Gene, 2001 Jan 10. PMID 11179667
  4. The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Sun J, et al. Mol Cell Biol, 2013 Mar. PMID 23263983, Free PMC Article
  5. The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth. Cao J, et al. Sci Signal, 2015 Sep 1. PMID 26329581

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma.
    Title: The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.
  2. EYA1 is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact.
    Title: The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
anaphase-promoting complex subunit 1
Names
cyclosome subunit 1
meiotic check point regulator
mitotic checkpoint regulator
testis-specific gene 24 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008569.2 → NP_032595.2  anaphase-promoting complex subunit 1

    See identical proteins and their annotated locations for NP_032595.2

    Status: VALIDATED

    Source sequence(s)
    AK034858, AK077847, BB676785, BC139002, BE987509
    Consensus CDS
    CCDS16715.1
    UniProtKB/Swiss-Prot
    A2ATQ4, P53995, Q8BP33, Q8C772
    UniProtKB/TrEMBL
    B7ZNX2
    Related
    ENSMUSP00000014499.4, ENSMUST00000014499.10
    Conserved Domains (2) summary
    pfam01851
    Location:1467 → 1501
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:150 → 218
    ANAPC1; Anaphase-promoting complex subunit 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    128452003..128529558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248086.2 → XP_030103946.1  anaphase-promoting complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    B7ZNX2
    Conserved Domains (2) summary
    pfam01851
    Location:1349 → 1383
    PC_rep; Proteasome/cyclosome repeat
    pfam18122
    Location:1618 → 1777
    APC1_C; Anaphase-promoting complex sub unit 1 C-terminal domain

  2. XM_011239332.4 → XP_011237634.1  anaphase-promoting complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A2ATQ5
    Related
    ENSMUSP00000105962.2, ENSMUST00000110333.2
    Conserved Domains (1) summary
    pfam12859
    Location:150 → 218
    ANAPC1; Anaphase-promoting complex subunit 1

RNA

  1. XR_004938638.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53995.2 GenPept UniProtKB/Swiss-Prot:P53995

Gene LinkOut

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