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Mbp myelin basic protein [ Mus musculus (house mouse) ]

Gene ID: 17196, updated on 21-Apr-2024

Summary

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Official Symbol
Mbpprovided by MGI
Official Full Name
myelin basic proteinprovided by MGI
Primary source
MGI:MGI:96925
See related
Ensembl:ENSMUSG00000041607 AllianceGenome:MGI:96925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
jve; mld; shi; Hmbpr; golli-mbp
Summary
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
Expression
Biased expression in cerebellum adult (RPKM 425.3), cortex adult (RPKM 253.5) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
18 E3; 18 55.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (82492883..82603762)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (82475091..82585637)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene galanin receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7618 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82641329-82641438 Neighboring gene STARR-seq mESC enhancer starr_45206 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82698694-82698847 Neighboring gene STARR-positive B cell enhancer ABC_E7619 Neighboring gene ribosomal protein L21, pseudogene 8 Neighboring gene STARR-seq mESC enhancer starr_45208 Neighboring gene predicted gene, 57823 Neighboring gene STARR-seq mESC enhancer starr_45213 Neighboring gene zinc finger protein 236 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82886249-82886432 Neighboring gene predicted gene 10524 Neighboring gene predicted gene, 50351 Neighboring gene microRNA 5112

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of Degenerating 21.5 kDa Isoform of Myelin Basic Protein in the Pathogenesis of the Relapse in Murine Relapsing-Remitting Experimental Autoimmune Encephalomyelitis and MS Autopsied Brain. Takano C, et al. Int J Mol Sci, 2023 May 2. PMID 37175866, Free PMC Article
  2. Myelin basic protein recovery during PKU mice lifespan and the potential role of microRNAs on its regulation. Bregalda A, et al. Neurobiol Dis, 2023 May. PMID 36948260
  3. White matter integrity in mice requires continuous myelin synthesis at the inner tongue. Meschkat M, et al. Nat Commun, 2022 Mar 4. PMID 35246535, Free PMC Article
  4. Derivation of Oligodendrocyte Precursors from Adult Bone Marrow Stromal Cells for Remyelination Therapy. Tsui YP, et al. Cells, 2021 Aug 22. PMID 34440935, Free PMC Article
  5. A role of oligodendrocytes in information processing. Moore S, et al. Nat Commun, 2020 Oct 30. PMID 33127910, Free PMC Article

See all (660) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of Degenerating 21.5 kDa Isoform of Myelin Basic Protein in the Pathogenesis of the Relapse in Murine Relapsing-Remitting Experimental Autoimmune Encephalomyelitis and MS Autopsied Brain.
    Title: Involvement of Degenerating 21.5 kDa Isoform of Myelin Basic Protein in the Pathogenesis of the Relapse in Murine Relapsing-Remitting Experimental Autoimmune Encephalomyelitis and MS Autopsied Brain.
  2. Myelin basic protein recovery during PKU mice lifespan and the potential role of microRNAs on its regulation.
    Title: Myelin basic protein recovery during PKU mice lifespan and the potential role of microRNAs on its regulation.
  3. Developmental expression of genes involved in progesterone synthesis, metabolism and action during the post-natal cerebellar myelination.
    Title: Developmental expression of genes involved in progesterone synthesis, metabolism and action during the post-natal cerebellar myelination.
  4. Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities.
    Title: Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities.
  5. mouse MBP C8 (charge: +13) is still incorporated near cholesterol-enriched regions without SM. Thus, the highly charged C1 variant (charge: +19) needs a specific interaction with SM, whereas for C8 the incorporation at the cholesterol-rich regions is ensured due to its reduced net positive charge.
    Title: Myelin basic protein (MBP) charge variants show different sphingomyelin-mediated interactions with myelin-like lipid monolayers.
  6. In the cerebellum of the animals with antiphospholipid syndrome, it was established that the level of MBP (95-110 kDa) increased in more than 5 times (p<0.001), while the MBP (18.4 kDa) was found in very small amounts compare to the control
    Title: [MIELIN BASIC PROTEIN IN THE BRAIN TISSUE OF THE BALB/C MICE WITH EXPERIMENTAL ANTIPHOSPHOLIPID SYNDROME AND AFFECTION WITH NITRIC OXIDE SYNTHESIS MODULATORS].
  7. Myelin basic protein and the cytoplasmic domain of myelin protein zero bound and aggregated negatively charged lipid vesicles, while simultaneously folding, and both ionic strength and calcium had systematic effects on these interactions.
    Title: Ionic strength and calcium regulate membrane interactions of myelin basic protein and the cytoplasmic domain of myelin protein zero.
  8. Results support the formation of an amorphous protein phase of MBP between two membrane bilayers and provide a molecular model for major dense line formation during myelination, which is of importance when understanding myelin assembly and demyelinating conditions.
    Title: Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line.
  9. findings suggest that the acetylation and methylation of lysine on MBP are post-translational modifications associated with the neurological disability produced by EAE.
    Title: Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.
  10. golli-KO mice display abnormal behavior including deficits in episodic memory and reduced anxiety.
    Title: Golli Myelin Basic Proteins Modulate Voltage-Operated Ca(++) Influx and Development in Cortical and Hippocampal Neurons.
Submit: New GeneRIF Correction See all GeneRIFs (70)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of myelin sheath ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within membrane organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in myelination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within myelination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to progesterone ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to toxic substance IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in compact myelin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in compact myelin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in compact myelin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in internode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in internode region of axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in myelin sheath HDA PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myelin basic protein; Golli-Mbp
Names
myelin A1 protein
myelin deficient
shiverer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025245.1 → NP_001020416.1  Golli-Mbp isoform 2

    See identical proteins and their annotated locations for NP_001020416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains 3 exons unique to Golli-Mbp and exon 1 of the classic Mbp. It encodes the shorter of the Golli-Mbp isoforms (2).
    Source sequence(s)
    AC117825, AK039047, AK040716
    Consensus CDS
    CCDS29374.1
    UniProtKB/TrEMBL
    Q5D096
    Related
    ENSMUSP00000089393.5, ENSMUST00000091789.11
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 193
    Myelin_MBP; Myelin basic protein

  2. NM_001025251.2 → NP_001020422.1  myelin basic protein isoform 1

    See identical proteins and their annotated locations for NP_001020422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest of the classic Mbp isoforms (1).
    Source sequence(s)
    AC119259, BF457157, BY245551, CO425201
    Consensus CDS
    CCDS29376.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000121855.3, ENSMUST00000123251.9
    Conserved Domains (1) summary
    pfam01669
    Location:14 → 194
    Myelin_MBP; Myelin basic protein

  3. NM_001025254.2 → NP_001020425.1  myelin basic protein isoform 2

    See identical proteins and their annotated locations for NP_001020425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exon 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (2) that is missing a 11 aa segment compared to isoform 1.
    Source sequence(s)
    BB633793, BC004704
    Consensus CDS
    CCDS37875.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000114630.3, ENSMUST00000153478.9
    Conserved Domains (1) summary
    pfam01669
    Location:14 → 183
    Myelin_MBP; Myelin basic protein

  4. NM_001025255.2 → NP_001020426.1  myelin basic protein isoform 3

    See identical proteins and their annotated locations for NP_001020426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks exon 2 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (3) that is missing a 26 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, BY245551, CK623660
    Consensus CDS
    CCDS29377.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000115082.3, ENSMUST00000142850.9
    Conserved Domains (1) summary
    pfam01669
    Location:14 → 168
    Myelin_MBP; Myelin basic protein

  5. NM_001025256.2 → NP_001020427.1  myelin basic protein isoform 4

    See identical proteins and their annotated locations for NP_001020427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks exon 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (4) that is missing a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, AK079621, BY245551
    Consensus CDS
    CCDS29378.1
    UniProtKB/TrEMBL
    A0A498WGS3, Q542T4
    Related
    ENSMUSP00000115409.3, ENSMUST00000152071.9
    Conserved Domains (1) summary
    pfam01669
    Location:14 → 148
    Myelin_MBP; Myelin basic protein

  6. NM_001025258.2 → NP_001020429.1  myelin basic protein isoform 5

    See identical proteins and their annotated locations for NP_001020429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks exons 2 and 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (5) that is missing a 26 aa and a 11 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, BY245551, M15062
    Consensus CDS
    CCDS29379.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000114230.3, ENSMUST00000132369.3
    Conserved Domains (1) summary
    pfam01669
    Location:14 → 157
    Myelin_MBP; Myelin basic protein

  7. NM_001025259.2 → NP_001020430.1  myelin basic protein isoform 6

    See identical proteins and their annotated locations for NP_001020430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks exons 2 and 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (6) that is missing a 26 aa and a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, AK005129, BY245551
    Consensus CDS
    CCDS89290.1
    UniProtKB/TrEMBL
    A0A498WGS3, Q3UGF3
    Related
    ENSMUSP00000116019.3, ENSMUST00000133193.9
    Conserved Domains (1) summary
    pfam01669
    Location:14 → 122
    Myelin_MBP; Myelin basic protein

  8. NM_010777.3 → NP_034907.1  Golli-Mbp isoform 1

    See identical proteins and their annotated locations for NP_034907.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains 3 exons unique to Golli-Mbp and exons 1, 3, 4 and 7 of the classic Mbp. It encodes the longer of the Golli-Mbp isoforms (1).
    Source sequence(s)
    AC117825, AC119259, L07507
    Consensus CDS
    CCDS29373.1
    UniProtKB/Swiss-Prot
    P04370, Q01585, Q03139, Q03176, Q61836, Q61837, Q99KE4, Q9QWP1
    UniProtKB/TrEMBL
    A0A411P8U6
    Related
    ENSMUSP00000046185.8, ENSMUST00000047865.14
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 248
    Myelin_MBP; Myelin basic protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    82492883..82603762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526452.5 → XP_006526515.1  Golli-Mbp isoform X1

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 349
    Myelin_MBP; Myelin basic protein

  2. XM_006526455.3 → XP_006526518.1  Golli-Mbp isoform X5

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 308
    Myelin_MBP; Myelin basic protein

  3. XM_006526453.4 → XP_006526516.1  Golli-Mbp isoform X2

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 327
    Myelin_MBP; Myelin basic protein

  4. XM_006526457.4 → XP_006526520.1  Golli-Mbp isoform X8

    See identical proteins and their annotated locations for XP_006526520.1

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 274
    Myelin_MBP; Myelin basic protein

  5. XM_036161011.1 → XP_036016904.1  Golli-Mbp isoform X4

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 317
    Myelin_MBP; Myelin basic protein

  6. XM_006526454.4 → XP_006526517.1  Golli-Mbp isoform X3

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 324
    Myelin_MBP; Myelin basic protein

  7. XM_030250358.2 → XP_030106218.1  Golli-Mbp isoform X9

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 282
    Myelin_MBP; Myelin basic protein

  8. XM_006526458.4 → XP_006526521.1  Golli-Mbp isoform X10

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 248
    Myelin_MBP; Myelin basic protein

  9. XM_006526456.4 → XP_006526519.1  Golli-Mbp isoform X6

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 301
    Myelin_MBP; Myelin basic protein

  10. XM_036161013.1 → XP_036016906.1  Golli-Mbp isoform X7

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 291
    Myelin_MBP; Myelin basic protein

  11. XM_036161014.1 → XP_036016907.1  myelin basic protein isoform X11

    Conserved Domains (1) summary
    pfam01669
    Location:14 → 217
    Myelin_MBP; Myelin basic protein

  12. XM_036161010.1 → XP_036016903.1  Golli-Mbp isoform X3

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 324
    Myelin_MBP; Myelin basic protein

  13. XM_030250356.1 → XP_030106216.1  Golli-Mbp isoform X1

    UniProtKB/TrEMBL
    A0A411P8U6
    Conserved Domains (1) summary
    pfam01669
    Location:147 → 349
    Myelin_MBP; Myelin basic protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04370.2 GenPept UniProtKB/Swiss-Prot:P04370

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