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Mb myoglobin [ Mus musculus (house mouse) ]

Gene ID: 17189, updated on 21-Apr-2024

Summary

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Official Symbol
Mbprovided by MGI
Official Full Name
myoglobinprovided by MGI
Primary source
MGI:MGI:96922
See related
Ensembl:ENSMUSG00000018893 AllianceGenome:MGI:96922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable oxygen binding activity. Acts upstream of or within several processes, including brown fat cell differentiation; enucleate erythrocyte differentiation; and response to hypoxia. Is expressed in brown fat; heart; skeletal muscle; and somite. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human MB (myoglobin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 4675.2) See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 36.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76899687..76934868, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77015487..77050668, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53916 Neighboring gene predicted gene, 52199 Neighboring gene VISTA enhancer mm106 Neighboring gene STARR-seq mESC enhancer starr_39074 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:76901831-76902180 Neighboring gene apolipoprotein L 6 Neighboring gene predicted gene, 24753 Neighboring gene predicted gene, 53899 Neighboring gene RNA binding protein, fox-1 homolog (C. elegans) 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice. Aboouf MA, et al. Sci Rep, 2023 May 9. PMID 37161046, Free PMC Article
  2. Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets. Aboouf MA, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Dec. PMID 34384891
  3. On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice. Blackburn ML, et al. Am J Physiol Endocrinol Metab, 2021 Jul 1. PMID 33969705, Free PMC Article
  4. Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice. Ono-Moore KD, et al. Am J Physiol Endocrinol Metab, 2021 Jul 1. PMID 33969704, Free PMC Article
  5. Effect of fatty acid interaction on myoglobin oxygen affinity and triglyceride metabolism. Jue T, et al. J Physiol Biochem, 2016 Aug. PMID 28357578

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis.
    Title: Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis.
  2. Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice.
    Title: Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice.
  3. Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets.
    Title: Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets.
  4. The authors here unravel a novel role of cardiac myoglobin in governing fatty acid metabolism to ensure the physiological energy production through beta-oxidation, preventing myocardial lipid accumulation and preserving cardiac functions.
    Title: A novel physiological role for cardiac myoglobin in lipid metabolism.
  5. Inhibition of mammalian target of rapamycin (mTOR) activation using rapamycin restored Mb mRNA expression to control levels. Lipid supplementation had no effect on Mb gene expression. Thus, IGF-1-induced anabolic signaling can be a strategy to improve muscle size under mild hypoxia, but lowers Mb gene expression
    Title: IGF-1 Attenuates Hypoxia-Induced Atrophy but Inhibits Myoglobin Expression in C2C12 Skeletal Muscle Myotubes.
  6. the novel cancer-associated MB splice variants exhibited increased expression in tumor cells subjected to experimental hypoxia; the novel gene regulatory mechanisms unveiled in this study support the idea of a non-canonical role of MB during carcinogenesis
    Title: Extensive transcriptional complexity during hypoxia-regulated expression of the myoglobin gene in cancer.
  7. Myoglobin overexpression inhibits reperfusion in the ischemic mouse hindlimb through impaired angiogenesis but not arteriogenesis
    Title: Myoglobin overexpression inhibits reperfusion in the ischemic mouse hindlimb through impaired angiogenesis but not arteriogenesis.
  8. Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.
    Title: Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.
  9. Show a high capacity of myoglobin-deficient mice to adapt to catecholamine induced cardiac stress which is associated with activation of a distinct cardiac gene expression program.
    Title: Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy.
  10. Endogenous nitrite reduction to NO. via the heme globin myoglobin enhances blood flow and matches O(2) supply to increased metabolic demands under hypoxic conditions.
    Title: Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nitrite reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
  
enables oxygen carrier activity ISO
Inferred from Sequence Orthology
more info
  
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within enucleate erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxygen transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oxygen transport ISO
Inferred from Sequence Orthology
more info
  
involved_in removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in sarcoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myoglobin
Names
nitrite reductase MB
pseudoperoxidase MB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164047.1 → NP_001157519.1  myoglobin

    See identical proteins and their annotated locations for NP_001157519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AC157554, AK137456, BX527493
    Consensus CDS
    CCDS27597.1
    UniProtKB/Swiss-Prot
    P04247
    UniProtKB/TrEMBL
    Q3UVB1
    Related
    ENSMUSP00000125995.2, ENSMUST00000169226.9
    Conserved Domains (1) summary
    cl21461
    Location:6 → 154
    Globin-like; Globin-like protein superfamily

  2. NM_001164048.1 → NP_001157520.1  myoglobin

    See identical proteins and their annotated locations for NP_001157520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AA271284, AK137456, BX527493
    Consensus CDS
    CCDS27597.1
    UniProtKB/Swiss-Prot
    P04247
    UniProtKB/TrEMBL
    Q3UVB1
    Related
    ENSMUSP00000019037.9, ENSMUST00000019037.10
    Conserved Domains (1) summary
    cl21461
    Location:6 → 154
    Globin-like; Globin-like protein superfamily

  3. NM_013593.3 → NP_038621.2  myoglobin

    See identical proteins and their annotated locations for NP_038621.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AC157554, AL603843, BX527493
    Consensus CDS
    CCDS27597.1
    UniProtKB/Swiss-Prot
    P04247
    UniProtKB/TrEMBL
    Q3UVB1
    Related
    ENSMUSP00000128399.2, ENSMUST00000166179.9
    Conserved Domains (1) summary
    cl21461
    Location:6 → 154
    Globin-like; Globin-like protein superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76899687..76934868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04247.3 GenPept UniProtKB/Swiss-Prot:P04247

Gene LinkOut

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