U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Matk megakaryocyte-associated tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 17179, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Matkprovided by MGI
Official Full Name
megakaryocyte-associated tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:99259
See related
Ensembl:ENSMUSG00000004933 AllianceGenome:MGI:99259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHK; HYL; Ntk; p56ntk
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm and membrane. Is expressed in brain; gonad; hemolymphoid system gland; and intestine. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 63.6), frontal lobe adult (RPKM 48.8) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Matk in Genome Data Viewer
Location:
10 39.72 cM; 10 C1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81088769..81098819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81252935..81262985)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene ataxia, cerebellar, Cayman type Neighboring gene zinc finger RNA binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E6886 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene amyloid beta precursor protein binding family A member 3 Neighboring gene microRNA 3057

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. c-Src-Dependent and -Independent Functions of Matk in Osteoclasts and Osteoblasts. Kim JH, et al. J Immunol, 2018 Apr 1. PMID 29440352
  2. Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice. Hamaguchi I, et al. Biochem Biophys Res Commun, 1996 Jul 5. PMID 8694808
  3. [VNK--a new gene for nonreceptor protein-tyrosine kinase, expressed in the murine brain and hematopoietic system]. Ershler MA, et al. Dokl Akad Nauk, 1994 Dec. PMID 7874011
  4. Structure and developmental regulation of the murine ctk gene. Brinkley PM, et al. Gene, 1995 Oct 3. PMID 7590263
  5. Genomic structure and alternative splicing of the murine bhk/ctk/ntk gene. Ershler MA, et al. FEBS Lett, 1995 Nov 13. PMID 7498479

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC130505

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
megakaryocyte-associated tyrosine-protein kinase
Names
Csk homologous kinase
protein kinase NTK
tyrosine protein kinase
tyrosine-protein kinase CTK
NP_001272782.1
NP_001272783.1
NP_001272784.1
NP_034898.1
XP_006513357.1
XP_006513358.1
XP_006513361.1
XP_006513362.1
XP_011241678.1
XP_011241679.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285853.2 → NP_001272782.1  megakaryocyte-associated tyrosine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001272782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS70077.1
    UniProtKB/TrEMBL
    D3Z4T5, P70223, Q9D6H7
    Related
    ENSMUSP00000113043.2, ENSMUST00000121205.8
    Conserved Domains (3) summary
    cd09937
    Location:77 → 174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:9 → 67
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:187 → 440
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001285854.2 → NP_001272783.1  megakaryocyte-associated tyrosine-protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001272783.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 7 all encode the same isoform (3).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS70078.1
    UniProtKB/TrEMBL
    A0A0R4J1P8, P70223, Q9D6H7
    Related
    ENSMUSP00000100965.4, ENSMUST00000105328.10
    Conserved Domains (3) summary
    cd09937
    Location:76 → 173
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:8 → 66
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:186 → 439
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001285855.2 → NP_001272784.1  megakaryocyte-associated tyrosine-protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001272784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1. Variants 3, 4, and 7 all encode the same isoform (3).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS70078.1
    UniProtKB/TrEMBL
    A0A0R4J1P8, P70223, Q9D6H7
    Related
    ENSMUSP00000113576.2, ENSMUST00000119547.8
    Conserved Domains (3) summary
    cd09937
    Location:76 → 173
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:8 → 66
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:186 → 439
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001428580.1 → NP_001415509.1  megakaryocyte-associated tyrosine-protein kinase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/TrEMBL
    A0A0R4J1N6

  5. NM_001428581.1 → NP_001415510.1  megakaryocyte-associated tyrosine-protein kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/TrEMBL
    D3Z4T5

  6. NM_001428582.1 → NP_001415511.1  megakaryocyte-associated tyrosine-protein kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/TrEMBL
    A0A0R4J1P8

  7. NM_010768.3 → NP_034898.1  megakaryocyte-associated tyrosine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_034898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5 both encode the same isoform (1).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS24048.1
    UniProtKB/Swiss-Prot
    P41242, Q6LE90
    UniProtKB/TrEMBL
    A0A0R4J1N6
    Related
    ENSMUSP00000113221.2, ENSMUST00000117488.8
    Conserved Domains (3) summary
    cd09937
    Location:116 → 213
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:48 → 106
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:226 → 479
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81088769..81098819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513298.4 → XP_006513361.1  megakaryocyte-associated tyrosine-protein kinase isoform X5

    Related
    ENSMUSP00000113666.2, ENSMUST00000120265.2
    Conserved Domains (3) summary
    cd09937
    Location:77 → 174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:9 → 67
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:187 → 440
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011243376.3 → XP_011241678.1  megakaryocyte-associated tyrosine-protein kinase isoform X3

    UniProtKB/TrEMBL
    P70223, Q9D6H7
    Conserved Domains (3) summary
    cd09937
    Location:103 → 200
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:35 → 93
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:213 → 466
    PKc_like; Protein Kinases, catalytic domain

  3. XM_011243377.3 → XP_011241679.1  megakaryocyte-associated tyrosine-protein kinase isoform X4

    UniProtKB/TrEMBL
    P70223, Q9D6H7
    Conserved Domains (3) summary
    cd09937
    Location:102 → 199
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:34 → 92
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:212 → 465
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006513299.4 → XP_006513362.1  megakaryocyte-associated tyrosine-protein kinase isoform X6

    Conserved Domains (3) summary
    cd09937
    Location:76 → 173
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:8 → 66
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:186 → 439
    PKc_like; Protein Kinases, catalytic domain

  5. XM_006513295.5 → XP_006513358.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

    Conserved Domains (3) summary
    cd09937
    Location:116 → 213
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:48 → 106
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:226 → 479
    PKc_like; Protein Kinases, catalytic domain

  6. XM_006513294.4 → XP_006513357.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    P41242, Q6LE90
    Conserved Domains (3) summary
    cd09937
    Location:117 → 214
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:49 → 107
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:227 → 480
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41242.2 GenPept UniProtKB/Swiss-Prot:P41242

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous