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Ccndbp1 cyclin D-type binding-protein 1 [ Mus musculus (house mouse) ]

Gene ID: 17151, updated on 3-Apr-2024

Summary

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Official Symbol
Ccndbp1provided by MGI
Official Full Name
cyclin D-type binding-protein 1provided by MGI
Primary source
MGI:MGI:109595
See related
Ensembl:ENSMUSG00000023572 AllianceGenome:MGI:109595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIP1; GCIP; Maid; SECC-8; SSEC-8
Summary
Predicted to be involved in regulation of cell cycle. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CCNDBP1 (cyclin D1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 18.2), bladder adult (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 60.37 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120838925..120847374)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121008395..121016912)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene expressed sequence AV039307 Neighboring gene ubiquitin protein ligase E3 component n-recognin 1 Neighboring gene STARR-positive B cell enhancer ABC_E5971 Neighboring gene STARR-positive B cell enhancer ABC_E147 Neighboring gene transmembrane protein 62 Neighboring gene small nucleolar RNA, C/D box 3B, pseudogene 2 Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene transglutaminase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ccndbp1 is a new positive regulator of skeletal myogenesis. Huang Y, et al. J Cell Sci, 2016 Jul 15. PMID 27235421
  2. Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis. Ma W, et al. Oncogene, 2006 Jul 13. PMID 16501603
  3. Maid is a negative regulator of transforming growth factor-β-induced cell migration. Motizuki M, et al. J Biochem, 2015 Nov. PMID 26002959
  4. Maid: a maternally transcribed novel gene encoding a potential negative regulator of bHLH proteins in the mouse egg and zygote. Hwang SY, et al. Dev Dyn, 1997 Jun. PMID 9186056
  5. Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition. Ishii R, et al. EMBO J, 2012 May 30. PMID 22453338, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
cyclin-D1-binding protein 1
Names
grap2 and cyclin-D-interacting protein
maternal Id-like protein
maternal inhibition of differentiation
stage specific embryonic cDNA-8 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355127.2 → NP_001342056.1  cyclin-D1-binding protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL844548
    UniProtKB/TrEMBL
    A0AA74IZC9
    Related
    ENSMUSP00000125961.4, ENSMUST00000171260.4
    Conserved Domains (1) summary
    pfam13324
    Location:52 → 305
    GCIP; Grap2 and cyclin-D-interacting

  2. NM_010761.3 → NP_034891.2  cyclin-D1-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_034891.2

    Status: VALIDATED

    Source sequence(s)
    AL844548
    Consensus CDS
    CCDS38213.1
    UniProtKB/Swiss-Prot
    Q3TVC7, Q3UMI3, Q61162, Q99JA7, Q99KG4
    UniProtKB/TrEMBL
    A0AA74IZC9
    Related
    ENSMUSP00000062496.9, ENSMUST00000060455.15
    Conserved Domains (1) summary
    pfam13324
    Location:52 → 316
    GCIP; Grap2 and cyclin-D-interacting

RNA

  1. NR_185170.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL844548

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120838925..120847374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239329.3 → XP_011237631.1  cyclin-D1-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam13324
    Location:1 → 133
    GCIP; Grap2 and cyclin-D-interacting
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TVC7.1 GenPept UniProtKB/Swiss-Prot:Q3TVC7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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