H1f8 H1.8 linker histone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H1f8provided by MGI
Official Full Name: H1.8 linker histoneprovided by MGI
Primary source: MGI:MGI:2176207
See related: Ensembl:ENSMUSG00000042279 AllianceGenome:MGI:2176207
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H1-8; H1.8; H1fo; H1oo; H1foo
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes and the encoded protein is expressed only in oocytes. [provided by RefSeq, Oct 2015]
Expression: Restricted expression toward ovary adult (RPKM 8.4) See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 53.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (115921892..115927203)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (115944931..115950242)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility.
Title: The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility.
Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci.
Title: Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci.
H1foo is involved in the change in chromatin structure via nuclear deposition of H3 variants between the one- and two-cell stages.
Title: Linker histone H1FOO regulates the chromatin structure in mouse zygotes.
H1foo contributes to the generation of higher-quality induced pluripotent stem cells.
Title: H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.
H1foo has an impact on the genome-wide, locus-specific epigenetic status.
Title: Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency.
Promoter activities of three mouse maternal genes (H1oo, Npm2, and Zar1) in oocytes and pre-implantation embryos, and examined the promoters and to obttain the best promoter for oocytte gene expression.
Title: Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse.
The unmethylated status was continuously observed throughout oogenesis, in mature oocytes, and after fertilization, in E3.5 blastocysts. There is a continuously unmethylated circuit at the H1foo locus in the female germline.
Title: DNA hypomethylation circuit of the mouse oocyte-specific histone H1foo gene in female germ cell lineage.
that H1foo is essential for maturation of germinal vesicle-stage oocytes
Title: H1foo is indispensable for meiotic maturation of the mouse oocyte.
may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure
Title: H1oo: a pre-embryonic H1 linker histone in search of a function.
The expression of the oocytic H1FOO transcript and protein proved temporally coupled to the recruitment of resting primordial follicles into a developing primary follicular cohort and thus to the critical transition marking the onset of oocytic growth
Title: H1FOO is coupled to the initiation of oocytic growth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (3)

General gene information

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Markers

H1foo (e-PCR), detects polymorphism
- UniSTS:545839

H1foo (e-PCR), detects polymorphism
- UniSTS:528214

NoName (e-PCR)
- UniSTS:492926

RH126702 (e-PCR)
- UniSTS:208016

RH127285 (e-PCR)
- UniSTS:208017

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISA Inferred from Sequence Alignment more info	PubMed
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosomal DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of chromatin	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleosome assembly	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone H1.8

Names: H1 histone family, member O, oocyte-specific; histone H1oo; oocyte-specific histone H1; oocyte-specific linker histone H1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346702.1 → NP_001333631.1 histone H1.8 isoform 2

Status: REVIEWED

Source sequence(s)

AC142099, AK162154, DV655349

Consensus CDS

CCDS85133.1

UniProtKB/TrEMBL

E0CZ52

Related

ENSMUSP00000123797.2, ENSMUST00000161969.4
NM_138311.3 → NP_612184.1 histone H1.8 isoform 1

See identical proteins and their annotated locations for NP_612184.1

Status: REVIEWED

Source sequence(s)

AK135944, AV357657, CJ081178

Consensus CDS

CCDS20447.1

UniProtKB/Swiss-Prot

Q8VIK3

UniProtKB/TrEMBL

E0CZ52

Related

ENSMUSP00000036951.8, ENSMUST00000037831.14

Conserved Domains (1) summary

cd00073
Location:43 → 134

H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...