Mxd1 MAX dimerization protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mxd1provided by MGI
Official Full Name: MAX dimerization protein 1provided by MGI
Primary source: MGI:MGI:96908
See related: Ensembl:ENSMUSG00000001156 AllianceGenome:MGI:96908
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mad; Mad1
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including chromatin; mitochondrion; and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; integumental system; and sensory organ. Orthologous to human MXD1 (MAX dimerization protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in small intestine adult (RPKM 105.0), colon adult (RPKM 95.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 37.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (86624026..86646099, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (86647044..86669234, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway.
Title: HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway.
The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.
Title: The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.
1,25D and the VDR regulate the c-MYC/MXD1 network to suppress c-MYC function, providing a molecular basis for cancer preventive actions of vitamin D.
Title: Vitamin D receptor as a master regulator of the c-MYC/MXD1 network.
Phe-7 is the critical determinant and provides the molecular specificity for the association between Sin3 and Mad in regulating cell growth and differentiation.
Title: Molecular determinants of the interaction of Mad with the PAH2 domain of mSin3.
Mad1 is a transcriptional repressor of Bcl-6.
Title: Mad1 is a transcriptional repressor of Bcl-6.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW122478 (e-PCR)
- UniSTS:165476

X83106 (e-PCR)
- UniSTS:125870

Mxd1 (e-PCR), detects polymorphism
- UniSTS:507076

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Mad-Max complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: max dimerization protein 1

Names: max dimerizer 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410076.1 → NP_001397005.1 max dimerization protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC158662
NM_010751.4 → NP_034881.2 max dimerization protein 1 isoform 1

See identical proteins and their annotated locations for NP_034881.2

Status: VALIDATED

Source sequence(s)

AC158662

Consensus CDS

CCDS51835.1

UniProtKB/Swiss-Prot

P50538, Q60798, Q61825

UniProtKB/TrEMBL

Q4FK19, Q8K1Z8

Related

ENSMUSP00000001184.8, ENSMUST00000001184.10

Conserved Domains (1) summary

cd00083
Location:53 → 109

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...