U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vgll1 vestigial like family member 1 [ Mus musculus (house mouse) ]

Gene ID: 170828, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Vgll1provided by MGI
Official Full Name
vestigial like family member 1provided by MGI
Primary source
MGI:MGI:2655768
See related
Ensembl:ENSMUSG00000031131 AllianceGenome:MGI:2655768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tondu
Summary
Enables protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in adrenal gland. Orthologous to human VGLL1 (vestigial like family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 2.1), bladder adult (RPKM 0.1) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X A6; X 30.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (56133466..56151900)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (57088106..57106540)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene bombesin-like receptor 3 Neighboring gene HIV TAT specific factor 1 Neighboring gene STARR-seq mESC enhancer starr_47211 Neighboring gene predicted gene 14718 Neighboring gene CD40 ligand

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Pobbati AV, et al. Structure, 2012 Jul 3. PMID 22632831
  2. Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy. Gan P, et al. Sci Rep, 2020 May 5. PMID 32371981, Free PMC Article
  3. A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ. Kitagawa M. Biochem Biophys Res Commun, 2007 Oct 5. PMID 17689488
  4. Expression pattern of transcriptional enhanced associate domain family member 1 (Tead1) in developing mouse molar tooth. Niki Y, et al. Gene Expr Patterns, 2021 Jun. PMID 33984529
  5. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Correa SM, et al. Cell Rep, 2015 Jan 6. PMID 25543145, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription cofactor vestigial-like protein 1
Names
vestigial like 1 homolog
vestigial-related factor
vgl-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313763.1 → NP_001300692.1  transcription cofactor vestigial-like protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AL672128
    Consensus CDS
    CCDS30151.1
    UniProtKB/Swiss-Prot
    A2AFJ9, Q99NC0
    UniProtKB/TrEMBL
    A6H6P3
    Related
    ENSMUSP00000110393.3, ENSMUST00000114745.9
    Conserved Domains (1) summary
    pfam07545
    Location:21 → 51
    Vg_Tdu; Vestigial/Tondu family

  2. NM_133251.2 → NP_573514.1  transcription cofactor vestigial-like protein 1

    See identical proteins and their annotated locations for NP_573514.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AL672128
    Consensus CDS
    CCDS30151.1
    UniProtKB/Swiss-Prot
    A2AFJ9, Q99NC0
    UniProtKB/TrEMBL
    A6H6P3
    Related
    ENSMUSP00000033465.4, ENSMUST00000033465.10
    Conserved Domains (1) summary
    pfam07545
    Location:21 → 51
    Vg_Tdu; Vestigial/Tondu family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    56133466..56151900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99NC0.1 GenPept UniProtKB/Swiss-Prot:Q99NC0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous