mkrn1 makorin, ring finger protein, 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mkrn1provided by ZNC
Official Full Name: makorin, ring finger protein, 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-020213-1
See related: Ensembl:ENSDARG00000041665 AllianceGenome:ZFIN:ZDB-GENE-020213-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fl25h08; wu:fl25h08; zgc:110403
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Is expressed in several structures, including brain; eye; gonad; integument; and liver. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (12292285..12307039)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (12293436..12308190)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fl25h08.x1 (e-PCR)
- UniSTS:202106

fc24a07.y1 (e-PCR)
- UniSTS:193180

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable E3 ubiquitin-protein ligase makorin-1

Names: RING-type E3 ubiquitin transferase makorin-1

NP_694510.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152978.1 → NP_694510.1 probable E3 ubiquitin-protein ligase makorin-1

See identical proteins and their annotated locations for NP_694510.1

Status: PROVISIONAL

Source sequence(s)

BC095243

UniProtKB/Swiss-Prot

Q1L8F6, Q4VBT5, Q9DFG7

UniProtKB/TrEMBL

B2GQH3

Related

ENSDARP00000061069.6, ENSDART00000061070.8

Conserved Domains (5) summary

smart00356
Location:18 → 44

ZnF_C3H1; zinc finger

PHA03096
Location:176 → 325

PHA03096; p28-like protein; Provisional

cd00162
Location:235 → 290

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam15815
Location:357 → 437

MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal

pfam16131
Location:52 → 84

Torus; Torus domain