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Epcam epithelial cell adhesion molecule [ Mus musculus (house mouse) ]

Gene ID: 17075, updated on 16-Apr-2024

Summary

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Official Symbol
Epcamprovided by MGI
Official Full Name
epithelial cell adhesion moleculeprovided by MGI
Primary source
MGI:MGI:106653
See related
Ensembl:ENSMUSG00000045394 AllianceGenome:MGI:106653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EGP; Ly74; gp40; CD326; EGP-2; TROP1; Egp314; Ep-CAM; EpCAM1; Tacsd1; GA733-2; Tacstd1
Summary
Predicted to enable cadherin binding activity involved in cell-cell adhesion. Acts upstream of or within ureteric bud development. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study congenital diarrhea 5 with tufting enteropathy. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 346.5), colon adult (RPKM 315.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Epcam in Genome Data Viewer
Location:
17 E4; 17 57.87 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87943407..87958555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87635979..87651127)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1949 Neighboring gene predicted gene, 46587 Neighboring gene predicted gene, 46609 Neighboring gene STARR-seq mESC enhancer starr_43514 Neighboring gene STARR-positive B cell enhancer ABC_E7565 Neighboring gene STARR-seq mESC enhancer starr_43516 Neighboring gene mutS homolog 2 Neighboring gene STARR-seq mESC enhancer starr_43518 Neighboring gene STARR-seq mESC enhancer starr_43519 Neighboring gene potassium channel, subfamily K, member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Amelioration of Congenital Tufting Enteropathy in EpCAM (TROP1)-Deficient Mice via Heterotopic Expression of TROP2 in Intestinal Epithelial Cells. Nakato G, et al. Cells, 2020 Aug 6. PMID 32781650, Free PMC Article
  2. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Kuan II, et al. Sci Rep, 2017 Feb 3. PMID 28157205, Free PMC Article
  3. EpCAM Expressed by Murine Epidermal Langerhans Cells Modulates Immunization to an Epicutaneously Applied Protein Antigen. Ouchi T, et al. J Invest Dermatol, 2016 Aug. PMID 27106675, Free PMC Article
  4. Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction. Kozan PA, et al. J Mol Med (Berl), 2015 May. PMID 25482158, Free PMC Article
  5. Directional cell migration, but not proliferation, drives hair placode morphogenesis. Ahtiainen L, et al. Dev Cell, 2014 Mar 10. PMID 24636260

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM.
    Title: Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM.
  2. EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.
    Title: EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.
  3. Ectopic activation of the miR-200c-EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy.
    Title: Ectopic activation of the miR-200c-EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy.
  4. EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase.
    Title: EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase.
  5. EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions.
    Title: EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions.
  6. Amelioration of Congenital Tufting Enteropathy in EpCAM (TROP1)-Deficient Mice via Heterotopic Expression of TROP2 in Intestinal Epithelial Cells.
    Title: Amelioration of Congenital Tufting Enteropathy in EpCAM (TROP1)-Deficient Mice via Heterotopic Expression of TROP2 in Intestinal Epithelial Cells.
  7. proteolytic processing of EpCTF in single living cells
    Title: Membrane-associated epithelial cell adhesion molecule is slowly cleaved by γ-secretase prior to efficient proteasomal degradation of its intracellular domain.
  8. The expression of Epcam mRNA, which is a functional marker of potential hepatic stem-like cells, was controlled by LEF1, which was regulated by CLOCK.
    Title: Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system.
  9. EpEX/EpCAM are sufficient to reprogram fibroblasts into iPSCs with only Oct4 or Klf4.
    Title: EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α.
  10. extracellular vesicles tend to localize in the intestinal tract associated with epithelial cell adhesion molecule
    Title: EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding involved in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding involved in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in ureteric bud development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
epithelial cell adhesion molecule
Names
Trop-1 protein
epithelial glycoprotein 314
lymphocyte antigen 74
mEGP314
panepithelial glycoprotein 314
protein 289A
tumor-associated calcium signal transducer 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008532.2 → NP_032558.2  epithelial cell adhesion molecule precursor

    See identical proteins and their annotated locations for NP_032558.2

    Status: VALIDATED

    Source sequence(s)
    AK133510, AK167182, BI986346
    Consensus CDS
    CCDS29018.1
    UniProtKB/Swiss-Prot
    Q61512, Q99JW5
    Related
    ENSMUSP00000061935.9, ENSMUST00000053577.9
    Conserved Domains (1) summary
    cd00191
    Location:65 → 125
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    87943407..87958555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JW5.1 GenPept UniProtKB/Swiss-Prot:Q99JW5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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