U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cntnap4 contactin associated protein-like 4 [ Mus musculus (house mouse) ]

Gene ID: 170571, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cntnap4provided by MGI
Official Full Name
contactin associated protein-like 4provided by MGI
Primary source
MGI:MGI:2183572
See related
Ensembl:ENSMUSG00000031772 AllianceGenome:MGI:2183572
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Caspr4; E130114F09Rik
Summary
Involved in modulation of chemical synaptic transmission; regulation of grooming behavior; and regulation of synapse organization. Located in dendrite and presynaptic membrane. Is integral component of presynaptic membrane. Is active in GABA-ergic synapse. Is expressed in brain. Orthologous to human CNTNAP4 (contactin associated protein family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 7.4), CNS E18 (RPKM 5.5) and 5 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8 E1; 8 58.7 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (113296523..113609339)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (112569798..112882707)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22741 Neighboring gene predicted gene, 39254 Neighboring gene STARR-seq mESC enhancer starr_22743 Neighboring gene predicted gene, 26994 Neighboring gene STARR-seq mESC enhancer starr_22744 Neighboring gene STARR-seq mESC enhancer starr_22745 Neighboring gene STARR-seq mESC enhancer starr_22746 Neighboring gene STARR-seq mESC enhancer starr_22747 Neighboring gene STARR-seq mESC enhancer starr_22748 Neighboring gene STARR-seq mESC enhancer starr_22749 Neighboring gene predicted gene 45904 Neighboring gene STARR-seq mESC enhancer starr_22750 Neighboring gene STARR-seq mESC enhancer starr_22751 Neighboring gene STARR-seq mESC enhancer starr_22752 Neighboring gene predicted gene 10280

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Lactobacillus reuteri normalizes altered fear memory in male Cntnap4 knockout mice. Zhang W, et al. EBioMedicine, 2022 Dec. PMID 36395738, Free PMC Article
  2. Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte-microglia C3-C3aR pathway. Zhang W, et al. Cell Death Dis, 2023 Apr 22. PMID 37087484, Free PMC Article
  3. CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes. Zhang W, et al. Theranostics, 2020. PMID 32194851, Free PMC Article
  4. Neurexin Superfamily Cell Membrane Receptor Contactin-Associated Protein Like-4 (Cntnap4) Is Involved in Neural EGFL-Like 1 (Nell-1)-Responsive Osteogenesis. Li C, et al. J Bone Miner Res, 2018 Oct. PMID 29905970, Free PMC Article
  5. CNTNAP4 Impacts Epilepsy Through GABAA Receptors Regulation: Evidence From Temporal Lobe Epilepsy Patients and Mouse Models. Shangguan Y, et al. Cereb Cortex, 2018 Oct 1. PMID 28968899

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
    Title: Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
  2. Cntnap4 partial deficiency exacerbates alpha-synuclein pathology through astrocyte-microglia C3-C3aR pathway.
    Title: Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte-microglia C3-C3aR pathway.
  3. Lactobacillus reuteri normalizes altered fear memory in male Cntnap4 knockout mice.
    Title: Lactobacillus reuteri normalizes altered fear memory in male Cntnap4 knockout mice.
  4. CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.
    Title: CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.
  5. Down-regulation or overexpression of CNTNAP4 in the hippocampus influenced the expression of gamma-aminobutyric acid A receptor beta2/3 membrane protein, without affecting total GABAARbeta2/3 protein concentration in epileptic mice
    Title: CNTNAP4 Impacts Epilepsy Through GABAA Receptors Regulation: Evidence From Temporal Lobe Epilepsy Patients and Mouse Models.
  6. a novel biological functional axis for Nell-1 and Cntnap4 in osteogenesis and, potentially, in neural development and function, is reported.
    Title: Neurexin Superfamily Cell Membrane Receptor Contactin-Associated Protein Like-4 (Cntnap4) Is Involved in Neural EGFL-Like 1 (Nell-1)-Responsive Osteogenesis.
  7. Caspr4 inhibits neuronal differentiation in a LNX-dependent manner.
    Title: Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells.
  8. Cntnap4 is localized presynaptically and its loss leads to a reduction in the output of cortical parvalbumin (PV)-positive GABAergic (gamma-aminobutyric acid producing) basket cells.
    Title: Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of grooming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in presynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
contactin-associated protein-like 4
Names
cell recognition molecule Caspr4
cell recognition protein CASPR4
contactin associated protein 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130457.2 → NP_569724.2  contactin-associated protein-like 4 precursor

    See identical proteins and their annotated locations for NP_569724.2

    Status: PROVISIONAL

    Source sequence(s)
    BC034628
    Consensus CDS
    CCDS40482.1
    UniProtKB/Swiss-Prot
    Q8K002, Q99P47
    UniProtKB/TrEMBL
    D3YWB9
    Related
    ENSMUSP00000034225.7, ENSMUST00000034225.7
    Conserved Domains (6) summary
    smart00231
    Location:57 → 179
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:56 → 178
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:796 → 940
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:555 → 586
    EGF; EGF-like domain
    pfam02210
    Location:214 → 343
    Laminin_G_2; Laminin G domain
    cl00085
    Location:597 → 645
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    113296523..113609339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530730.3 → XP_006530793.1  contactin-associated protein-like 4 isoform X2

    Conserved Domains (2) summary
    cd00110
    Location:161 → 305
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam02210
    Location:413 → 540
    Laminin_G_2; Laminin G domain

  2. XM_030243313.2 → XP_030099173.1  contactin-associated protein-like 4 isoform X2

    Conserved Domains (2) summary
    cd00110
    Location:161 → 305
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam02210
    Location:413 → 540
    Laminin_G_2; Laminin G domain

  3. XM_006530729.5 → XP_006530792.1  contactin-associated protein-like 4 isoform X1

    Conserved Domains (4) summary
    cd00110
    Location:525 → 669
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl00085
    Location:326 → 374
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam00008
    Location:284 → 315
    EGF; EGF-like domain
    pfam02210
    Location:777 → 904
    Laminin_G_2; Laminin G domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P47.2 GenPept UniProtKB/Swiss-Prot:Q99P47

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous