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Ltbr lymphotoxin B receptor [ Mus musculus (house mouse) ]

Gene ID: 17000, updated on 11-Apr-2024

Summary

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Official Symbol
Ltbrprovided by MGI
Official Full Name
lymphotoxin B receptorprovided by MGI
Primary source
MGI:MGI:104875
See related
Ensembl:ENSMUSG00000030339 AllianceGenome:MGI:104875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ltar; TNFCR; Tnfbr; TNFRrp; LTbetaR; TNFR-RP; Tnfrsf3; TNFR2-RP; TNF-R-III
Summary
Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Acts upstream of or within myeloid dendritic cell differentiation. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and long bone. Orthologous to human LTBR (lymphotoxin beta receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 103.9), adrenal adult (RPKM 86.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Ltbr in Genome Data Viewer
Location:
6 F3; 6 59.32 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125283534..125291026, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125306571..125313885, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930417O13 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:125215268-125215572 Neighboring gene tubulin, alpha 3A Neighboring gene STARR-seq mESC enhancer starr_17336 Neighboring gene sodium channel, nonvoltage-gated 1 alpha Neighboring gene STARR-seq mESC enhancer starr_17338 Neighboring gene tumor necrosis factor receptor superfamily, member 1a Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 6 Neighboring gene predicted gene, 52918

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LTβR overexpression promotes plasma cell accumulation. Kotov JA, et al. PLoS One, 2022. PMID 35925983, Free PMC Article
  2. Lymphocyte access to lymphoma is impaired by high endothelial venule regression. Menzel L, et al. Cell Rep, 2021 Oct 26. PMID 34706240, Free PMC Article
  3. The gut microbiota induces Peyer's-patch-dependent secretion of maternal IgA into milk. Usami K, et al. Cell Rep, 2021 Sep 7. PMID 34496253
  4. Lymphotoxin β Receptor: a Crucial Role in Innate and Adaptive Immune Responses against Toxoplasma gondii. Tersteegen A, et al. Infect Immun, 2021 May 17. PMID 33753412, Free PMC Article
  5. Topological Structure and Robustness of the Lymph Node Conduit System. Novkovic M, et al. Cell Rep, 2020 Jan 21. PMID 31968261

See all (226) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CREB1 Transcriptionally Activates LTBR to Promote the NF-kappaB Pathway and Apoptosis in Lung Epithelial Cells.
    Title: CREB1 Transcriptionally Activates LTBR to Promote the NF-κB Pathway and Apoptosis in Lung Epithelial Cells.
  2. LTbetaR overexpression promotes plasma cell accumulation.
    Title: LTβR overexpression promotes plasma cell accumulation.
  3. The transcription factor Sox4 is required for thymic tuft cell development.
    Title: The transcription factor Sox4 is required for thymic tuft cell development.
  4. Redefining the Role of Lymphotoxin Beta Receptor in the Maintenance of Lymphoid Organs and Immune Cell Homeostasis in Adulthood.
    Title: Redefining the Role of Lymphotoxin Beta Receptor in the Maintenance of Lymphoid Organs and Immune Cell Homeostasis in Adulthood.
  5. Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LTbetaR Pathway during Listeria Infection.
    Title: Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LTβR Pathway during Listeria Infection.
  6. LIGHT/LTbetaR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
    Title: LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
  7. Inhibition of LTbetaR signalling activates WNT-induced regeneration in lung.
    Title: Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
  8. Langerhans cells activate lymphatic endothelial cells via the LIGHT-LTbetaR signaling axis to promote DC migration or tumor cell metastasis.
    Title: Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LTβR Signaling.
  9. LIGHT signaling through lymphotoxin beta receptor plays a critical role in the progression of experimental colitis
    Title: The Tumor Necrosis Factor Superfamily Members TNFSF14 (LIGHT), Lymphotoxin β and Lymphotoxin β Receptor Interact to Regulate Intestinal Inflammation.
  10. a role for LTbetaR in the initiation of thymus emigration that segregates from its control of medulla organization.
    Title: Endothelial cells act as gatekeepers for LTβR-dependent thymocyte emigration.
Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hematopoietic or lymphoid organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lymph node development TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 3
Names
LT-beta receptor
TNF receptor-related protein
lymphotoxin-beta receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010736.5 → NP_034866.1  tumor necrosis factor receptor superfamily member 3 precursor

    See identical proteins and their annotated locations for NP_034866.1

    Status: VALIDATED

    Source sequence(s)
    AC140324
    Consensus CDS
    CCDS20549.1
    UniProtKB/Swiss-Prot
    P50284
    UniProtKB/TrEMBL
    B2RRV3, Q3UK82
    Related
    ENSMUSP00000032489.8, ENSMUST00000032489.8
    Conserved Domains (3) summary
    cd00185
    Location:172 → 212
    TNFRSF; CRD2 [structural motif]
    cd10578
    Location:11 → 170
    TNFRSF3; Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), also known as lymphotoxin beta receptor (LTBR)
    cl22855
    Location:148 → 212
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125283534..125291026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165897.1 → XP_036021790.1  tumor necrosis factor receptor superfamily member 3 isoform X1

    Conserved Domains (3) summary
    cd00185
    Location:172 → 212
    TNFRSF; CRD2 [structural motif]
    cd10578
    Location:11 → 170
    TNFRSF3; Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), also known as lymphotoxin beta receptor (LTBR)
    cl22855
    Location:148 → 212
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50284.1 GenPept UniProtKB/Swiss-Prot:P50284

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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