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ZNF800 zinc finger protein 800 [ Homo sapiens (human) ]

Gene ID: 168850, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF800provided by HGNC
Official Full Name
zinc finger protein 800provided by HGNC
Primary source
HGNC:HGNC:27267
See related
Ensembl:ENSG00000048405 AllianceGenome:HGNC:27267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 4.8), testis (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF800 in Genome Data Viewer
Location:
7q31.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (127342859..127392708, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (128658405..128706384, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127010097..127032762, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18590 Neighboring gene GRM8 antisense RNA 1 Neighboring gene PRELI domain containing 3B pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18591 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:127032217-127032717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26585 Neighboring gene uncharacterized LOC105375490 Neighboring gene long intergenic non-protein coding RNA 3012 Neighboring gene VISTA enhancer hs1308 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:127223080-127224279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127224999-127225998 Neighboring gene GRIP and coiled-coil domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. Civelek M, et al. Am J Hum Genet, 2017 Mar 2. PMID 28257690, Free PMC Article
  2. Structured RNAs in the ENCODE selected regions of the human genome. Washietl S, et al. Genome Res, 2007 Jun. PMID 17568003, Free PMC Article
  3. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Denoeud F, et al. Genome Res, 2007 Jun. PMID 17567994, Free PMC Article
  4. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. Lampert F, et al. Elife, 2018 Jun 18. PMID 29911972, Free PMC Article
  5. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.
    Title: Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43301, MGC130032, MGC130033

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acinar cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 800

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176814.5 → NP_789784.2  zinc finger protein 800

    See identical proteins and their annotated locations for NP_789784.2

    Status: VALIDATED

    Source sequence(s)
    AK309674, BC110623, BG112338, BU581251, DA888007
    Consensus CDS
    CCDS5795.1
    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0
    UniProtKB/TrEMBL
    B7Z4V7
    Related
    ENSP00000265827.3, ENST00000265827.8
    Conserved Domains (4) summary
    sd00019
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618 → 640
    zf-C2H2; Zinc finger, C2H2 type
    pfam16622
    Location:355 → 383
    zf-C2H2_11; zinc-finger C2H2-type
    pfam16624
    Location:391 → 485
    zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    127342859..127392708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515859.4 → XP_011514161.1  zinc finger protein 800 isoform X1

    See identical proteins and their annotated locations for XP_011514161.1

    Conserved Domains (4) summary
    sd00019
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618 → 640
    zf-C2H2; Zinc finger, C2H2 type
    pfam16622
    Location:355 → 383
    zf-C2H2_11; zinc-finger C2H2-type
    pfam16624
    Location:391 → 485
    zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

  2. XM_047419942.1 → XP_047275898.1  zinc finger protein 800 isoform X2

  3. XM_006715868.5 → XP_006715931.1  zinc finger protein 800 isoform X1

    See identical proteins and their annotated locations for XP_006715931.1

    Conserved Domains (4) summary
    sd00019
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618 → 640
    zf-C2H2; Zinc finger, C2H2 type
    pfam16622
    Location:355 → 383
    zf-C2H2_11; zinc-finger C2H2-type
    pfam16624
    Location:391 → 485
    zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

  4. XM_006715869.5 → XP_006715932.1  zinc finger protein 800 isoform X2

    UniProtKB/TrEMBL
    B7Z4V7
    Conserved Domains (4) summary
    sd00019
    Location:456 → 476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:586 → 608
    zf-C2H2; Zinc finger, C2H2 type
    pfam16622
    Location:323 → 351
    zf-C2H2_11; zinc-finger C2H2-type
    pfam16624
    Location:359 → 453
    zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

  5. XM_006715867.5 → XP_006715930.1  zinc finger protein 800 isoform X1

    See identical proteins and their annotated locations for XP_006715930.1

    Conserved Domains (4) summary
    sd00019
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618 → 640
    zf-C2H2; Zinc finger, C2H2 type
    pfam16622
    Location:355 → 383
    zf-C2H2_11; zinc-finger C2H2-type
    pfam16624
    Location:391 → 485
    zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

  6. XM_047419941.1 → XP_047275897.1  zinc finger protein 800 isoform X1

  7. XM_047419949.1 → XP_047275905.1  zinc finger protein 800 isoform X6

  8. XM_047419946.1 → XP_047275902.1  zinc finger protein 800 isoform X4

  9. XM_047419945.1 → XP_047275901.1  zinc finger protein 800 isoform X4

  10. XM_047419943.1 → XP_047275899.1  zinc finger protein 800 isoform X3

    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0
    Related
    ENSP00000376988.1, ENST00000393312.5

  11. XM_047419948.1 → XP_047275904.1  zinc finger protein 800 isoform X5

  12. XM_005250181.5 → XP_005250238.1  zinc finger protein 800 isoform X3

    See identical proteins and their annotated locations for XP_005250238.1

    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0
    UniProtKB/TrEMBL
    B7Z4V7
    Related
    ENSP00000376989.1, ENST00000393313.5
    Conserved Domains (4) summary
    sd00019
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618 → 640
    zf-C2H2; Zinc finger, C2H2 type
    pfam16622
    Location:355 → 383
    zf-C2H2_11; zinc-finger C2H2-type
    pfam16624
    Location:391 → 485
    zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

  13. XM_047419947.1 → XP_047275903.1  zinc finger protein 800 isoform X5

  14. XM_047419944.1 → XP_047275900.1  zinc finger protein 800 isoform X3

    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    128658405..128706384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357402.1 → XP_054213377.1  zinc finger protein 800 isoform X1

  2. XM_054357405.1 → XP_054213380.1  zinc finger protein 800 isoform X2

  3. XM_054357401.1 → XP_054213376.1  zinc finger protein 800 isoform X1

  4. XM_054357403.1 → XP_054213378.1  zinc finger protein 800 isoform X1

  5. XM_054357404.1 → XP_054213379.1  zinc finger protein 800 isoform X2

  6. XM_054357400.1 → XP_054213375.1  zinc finger protein 800 isoform X1

  7. XM_054357413.1 → XP_054213388.1  zinc finger protein 800 isoform X6

  8. XM_054357410.1 → XP_054213385.1  zinc finger protein 800 isoform X4

  9. XM_054357407.1 → XP_054213382.1  zinc finger protein 800 isoform X3

    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0

  10. XM_054357412.1 → XP_054213387.1  zinc finger protein 800 isoform X5

  11. XM_054357406.1 → XP_054213381.1  zinc finger protein 800 isoform X3

    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0

  12. XM_054357409.1 → XP_054213384.1  zinc finger protein 800 isoform X4

  13. XM_054357408.1 → XP_054213383.1  zinc finger protein 800 isoform X3

    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0

  14. XM_054357411.1 → XP_054213386.1  zinc finger protein 800 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TB10.1 GenPept UniProtKB/Swiss-Prot:Q2TB10

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