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ZNF467 zinc finger protein 467 [ Homo sapiens (human) ]

Gene ID: 168544, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF467provided by HGNC
Official Full Name
zinc finger protein 467provided by HGNC
Primary source
HGNC:HGNC:23154
See related
Ensembl:ENSG00000181444 MIM:614040; AllianceGenome:HGNC:23154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EZI; Zfp467
Summary
The protein encoded by this gene is a zinc finger protein whose function has not yet been elucidated in humans. However, the mouse ortholog of this protein enhances adipocyte differentiation and suppresses osteoblast differentiation in bone marrow. The mouse protein also is a transcription factor for several genes and can help recruit histone deacetylase complexes. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in spleen (RPKM 2.9), kidney (RPKM 2.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7q36.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149764182..149776530, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150946102..150958226, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149461271..149470677, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149412332-149412964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149417350-149418244 Neighboring gene KRAB-A domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149432150-149433066 Neighboring gene uncharacterized LOC124901771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149438995-149439524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149463303-149463978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149479128-149479704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149480282-149480858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149480859-149481434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149482621-149483120 Neighboring gene Sharpr-MPRA regulatory region 4172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149484857-149485446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149487626-149488414 Neighboring gene SCO-spondin, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149496913-149497414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149497415-149497914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18769 Neighboring gene zinc finger protein 862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552405-149552958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552959-149553510 Neighboring gene ATP6V0E2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149570857-149571825 Neighboring gene ATPase H+ transporting V0 subunit e2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells. Gluscevic M, et al. Gene, 2020 May 5. PMID 32032745
  2. Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment. Quach JM, et al. J Biol Chem, 2011 Feb 11. PMID 21123171, Free PMC Article
  3. Altered DNA methylation profile in idiopathic pulmonary fibrosis. Sanders YY, et al. Am J Respir Crit Care Med, 2012 Sep 15. PMID 22700861, Free PMC Article
  4. Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. Saijou E, et al. J Biol Chem, 2007 Nov 2. PMID 17848547
  5. A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3. Nakayama K, et al. EMBO J, 2002 Nov 15. PMID 12426389, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. demonstrate that PCBP2 and ZNF467 impact adipogenic but not osteogenic differentiation, further supporting evidence that AMSCs and BMSCs appear to be adapted to their microenvironment
    Title: Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells.
  2. ZNF467 gene DNA methylation is importants in the pathogenesis of idiopathic pulmonary fibrosis.
    Title: Altered DNA methylation profile in idiopathic pulmonary fibrosis.
  3. These results identify EZI as a novel cargo protein for importin-7 and demonstrate a nucleocytoplasmic shuttling mechanism that is mediated by importin-7-dependent nuclear localization and CRM1-independent nuclear export.
    Title: Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 467
Names
zinc finger protein EZI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329856.2 → NP_001316785.1  zinc finger protein 467 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the coding region compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004877, BC038972, CV575107
    Consensus CDS
    CCDS87563.1
    UniProtKB/TrEMBL
    C9JAX3
    Related
    ENSP00000418011.1, ENST00000484747.5

  2. NM_207336.3 → NP_997219.1  zinc finger protein 467 isoform 1

    See identical proteins and their annotated locations for NP_997219.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004877, BC038972, BC052625, CV575107
    Consensus CDS
    CCDS5899.1
    UniProtKB/Swiss-Prot
    Q7Z7K2
    Related
    ENSP00000304769.3, ENST00000302017.4
    Conserved Domains (2) summary
    COG5048
    Location:190 → 565
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149764182..149776530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419936.1 → XP_047275892.1  zinc finger protein 467 isoform X4

    UniProtKB/Swiss-Prot
    Q7Z7K2

  2. XM_017011799.3 → XP_016867288.2  zinc finger protein 467 isoform X2

  3. XM_011515857.4 → XP_011514159.2  zinc finger protein 467 isoform X1

  4. XM_006715864.5 → XP_006715927.1  zinc finger protein 467 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:231 → 606
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257 → 279
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:271 → 296
    zf-H2C2_2; Zinc-finger double domain

  5. XM_047419937.1 → XP_047275893.1  zinc finger protein 467 isoform X1

  6. XM_005249961.6 → XP_005250018.1  zinc finger protein 467 isoform X4

    See identical proteins and their annotated locations for XP_005250018.1

    UniProtKB/Swiss-Prot
    Q7Z7K2
    Conserved Domains (2) summary
    COG5048
    Location:190 → 565
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_005249960.6 → XP_005250017.1  zinc finger protein 467 isoform X4

    See identical proteins and their annotated locations for XP_005250017.1

    UniProtKB/Swiss-Prot
    Q7Z7K2
    Conserved Domains (2) summary
    COG5048
    Location:190 → 565
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_005249959.5 → XP_005250016.1  zinc finger protein 467 isoform X4

    See identical proteins and their annotated locations for XP_005250016.1

    UniProtKB/Swiss-Prot
    Q7Z7K2
    Conserved Domains (2) summary
    COG5048
    Location:190 → 565
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    150946102..150958226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357394.1 → XP_054213369.1  zinc finger protein 467 isoform X4

  2. XM_054357389.1 → XP_054213364.1  zinc finger protein 467 isoform X2

  3. XM_054357388.1 → XP_054213363.1  zinc finger protein 467 isoform X1

  4. XM_054357391.1 → XP_054213366.1  zinc finger protein 467 isoform X3

  5. XM_054357396.1 → XP_054213371.1  zinc finger protein 467 isoform X1

  6. XM_054357392.1 → XP_054213367.1  zinc finger protein 467 isoform X4

  7. XM_054357395.1 → XP_054213370.1  zinc finger protein 467 isoform X4

  8. XM_054357390.1 → XP_054213365.1  zinc finger protein 467 isoform X3

  9. XM_054357393.1 → XP_054213368.1  zinc finger protein 467 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z7K2.1 GenPept UniProtKB/Swiss-Prot:Q7Z7K2

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