Lamc2 laminin, gamma 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lamc2provided by MGI
Official Full Name: laminin, gamma 2provided by MGI
Primary source: MGI:MGI:99913
See related: Ensembl:ENSMUSG00000026479 AllianceGenome:MGI:99913
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables heparin binding activity. Predicted to be involved in several processes, including neuron projection development; positive regulation of cell migration; and positive regulation of cell population proliferation. Predicted to act upstream of or within cell adhesion. Located in basement membrane. Part of laminin-5 complex. Is expressed in several structures, including alimentary system; basement membrane; central nervous system; genitourinary system; and skin. Used to study junctional epidermolysis bullosa Herlitz type and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa; junctional epidermolysis bullosa Herlitz type; junctional epidermolysis bullosa non-Herlitz type; and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 15.7), colon adult (RPKM 6.6) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 65.26 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (152998502..153062193, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (153122756..153186447, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth.
Title: LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth.
Study show that integrin alpha9beta1 antagonizes both alpha3beta1-dependent mTLD/BMP-1 expression and basement membrane (BM) assembly/maturation. These findings indicate a complex interplay between these two integrins whereby alpha3beta1 promotes, and coordinately, alpha9beta1 inhibits mTLD/BMP-1 production and laminin-gamma2 processing to effect timely BM assembly and maturation during wound healing.
Title: Opposing Roles of Epidermal Integrins α3β1 and α9β1 in Regulation of mTLD/BMP-1-Mediated Laminin-γ2 Processing during Wound Healing.
Data suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT and may be a potential therapeutic target.
Title: LAMC2 enhances the metastatic potential of lung adenocarcinoma.
Periostin was associated with laminin gamma2, and this association enhanced the proteolytic cleavage of the laminin gamma2 long form to produce its short form.
Title: Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing.
mutant mice develop a progressive blistering disease validated at the gross and microscopic levels to closely resemble generalized non-Herlitz junctional epidermolysis bullosa
Title: A mouse model of generalized non-Herlitz junctional epidermolysis bullosa.
Protein production was in excess of the amount required to form heterotrimeric laminin-332 and was associated with the migrating epithelial sheet, suggesting a potential role in wound healing for monomeric laminin-gamma2.
Title: Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model.
Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells.
Title: Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells.
integrin alpha3beta1 delays keratinocyte migration during wound re-epithelialization, by binding to the laminin-332 that is newly deposited on the wound bed.
Title: Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin.
Laminin gamma2 and laminin-332, despite their prominence in the lung, have a minimal role in lung development through the saccular stage.
Title: Lung development in laminin gamma2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation.
short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2
Title: Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lamc2 (e-PCR), detects polymorphism
- UniSTS:265664

Lamc2 (e-PCR), detects polymorphism
- UniSTS:265665

Lamc2 (e-PCR), detects polymorphism
- UniSTS:265666

Lamc2 (e-PCR), detects polymorphism
- UniSTS:265667

GDB:335857 (e-PCR)
- UniSTS:156611

RH124939 (e-PCR)
- UniSTS:161761

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of laminin-2 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-5 complex	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: laminin subunit gamma-2

Names: epiligrin subunit gamma; kalinin subunit gamma; kalinin/nicein/epiligrin 100 kDa subunit; laminin B2t chain; laminin gamma2 chain; laminin-5 subunit gamma; nicein subunit gamma; nicein, 100kD; nicein, 100kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008485.3 → NP_032511.3 laminin subunit gamma-2 precursor

See identical proteins and their annotated locations for NP_032511.3

Status: VALIDATED

Source sequence(s)

AC099735, BB617855, BU758039, CF733033, CJ094114, DV654715, DV658346

Consensus CDS

CCDS15369.1

UniProtKB/Swiss-Prot

Q61092

UniProtKB/TrEMBL

G5E874

Related

ENSMUSP00000027753.7, ENSMUST00000027753.13

Conserved Domains (4) summary

cd00055
Location:83 → 127

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02168
Location:614 → 1192

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00053
Location:139 → 184

Laminin_EGF; Laminin EGF domain

cl02548
Location:245 → 370

Laminin_B; Laminin B (Domain IV)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

152998502..153062193 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247927.2 → XP_011246229.1 laminin subunit gamma-2 isoform X2

UniProtKB/Swiss-Prot

Q61092

Conserved Domains (5) summary

smart00180
Location:27 → 65

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:398 → 446

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02168
Location:551 → 1129

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00053
Location:76 → 121

Laminin_EGF; Laminin EGF domain

cl02548
Location:182 → 307

Laminin_B; Laminin B (Domain IV)
XM_011247926.3 → XP_011246228.1 laminin subunit gamma-2 isoform X1

See identical proteins and their annotated locations for XP_011246228.1

UniProtKB/Swiss-Prot

Q61092

UniProtKB/TrEMBL

G5E874

Related

ENSMUSP00000140514.2, ENSMUST00000185356.7

Conserved Domains (4) summary

cd00055
Location:83 → 127

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02168
Location:614 → 1192

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00053
Location:139 → 184

Laminin_EGF; Laminin EGF domain

cl02548
Location:245 → 370

Laminin_B; Laminin B (Domain IV)