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Lamb3 laminin, beta 3 [ Mus musculus (house mouse) ]

Gene ID: 16780, updated on 5-Mar-2024

Summary

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Official Symbol
Lamb3provided by MGI
Official Full Name
laminin, beta 3provided by MGI
Primary source
MGI:MGI:99915
See related
Ensembl:ENSMUSG00000026639 AllianceGenome:MGI:99915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be an extracellular matrix structural constituent. Acts upstream of or within brown fat cell differentiation. Located in basement membrane. Part of laminin-5 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study junctional epidermolysis bullosa Herlitz type and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1A; junctional epidermolysis bullosa; junctional epidermolysis bullosa Herlitz type; junctional epidermolysis bullosa non-Herlitz type; and lung small cell carcinoma. Orthologous to human LAMB3 (laminin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 41.0), lung adult (RPKM 26.5) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Lamb3 in Genome Data Viewer
Location:
1 H6; 1 97.71 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (192976661..193026186)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (193294353..193343878)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03470 Neighboring gene STARR-positive B cell enhancer ABC_E8 Neighboring gene hydroxysteroid 11-beta dehydrogenase 1 Neighboring gene STARR-seq mESC enhancer starr_03471 Neighboring gene STARR-positive B cell enhancer mm9_chr1:195090138-195090438 Neighboring gene G0/G1 switch gene 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:195164577-195164848 Neighboring gene predicted gene, 51741 Neighboring gene calcium/calmodulin-dependent protein kinase I gamma Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:195273620-195273803 Neighboring gene VISTA enhancer mm935 Neighboring gene STARR-seq mESC enhancer starr_03474 Neighboring gene predicted gene, 38022

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new mouse model of junctional epidermolysis bullosa: the LAMB3 628G>A knockin mouse. Hammersen J, et al. J Invest Dermatol, 2015 Mar. PMID 25350318
  2. Tissue substructure-specific deposition of the β3-containing laminin-332 in the biliary epithelium of human and mouse livers. Yamada M, et al. Biochem Biophys Res Commun, 2020 Apr 2. PMID 32008745
  3. Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5. Hashimoto J, et al. Exp Cell Res, 2005 Nov 1. PMID 16165127
  4. Differential expression of laminin-5 subunits during incisor and molar development in the mouse. Yoshiba K, et al. Int J Dev Biol, 2000 Apr. PMID 10853832
  5. Developmental expression of laminin-5 and HD1 in the intestine: epithelial to mesenchymal shift for the laminin gamma-2 chain subunit deposition. Orian-Rousseau V, et al. Dev Dyn, 1996 May. PMID 9019243

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SOX10 deficiency-mediated LAMB3 upregulation determines the invasiveness of MAPKi-resistant melanoma.
    Title: SOX10 deficiency-mediated LAMB3 upregulation determines the invasiveness of MAPKi-resistant melanoma.
  2. Tissue substructure-specific deposition of the beta3-containing laminin-332 in the biliary epithelium of human and mouse livers.
    Title: Tissue substructure-specific deposition of the β3-containing laminin-332 in the biliary epithelium of human and mouse livers.
  3. A new mouse model of junctional epidermolysis bullosa has been characterized by the LAMB3 628G>A knockin mouse.
    Title: A new mouse model of junctional epidermolysis bullosa: the LAMB3 628G>A knockin mouse.
  4. Data suggest that the proper expression of laminin-332 (Lamb3) and laminin-511 (lama5) may regulate appropriate hair morphogenesis.
    Title: Spatial and temporal control of laminin-332 and -511 expressions during hair morphogenesis.
  5. Data show thatincreased mRNA of Lamb3 and Adamts2 and enhanced activities of metalloproteinases MMP1, 2 and 7 in transgenic mice expressing the HLA-DQ8.
    Title: A deregulated immune response to gliadin causes a decreased villus height in DQ8 transgenic mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in basement membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
part_of laminin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of laminin-5 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
laminin subunit beta-3
Names
epiligrin subunit bata
kalinin B1 chain
kalinin subunit beta
laminin-5 subunit beta
nicein subunit beta
nicein, 125kD
nicein, 125kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277928.1 → NP_001264857.1  laminin subunit beta-3 precursor

    See identical proteins and their annotated locations for NP_001264857.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC022675
    Consensus CDS
    CCDS15637.1
    UniProtKB/Swiss-Prot
    Q61087, Q91V90
    Related
    ENSMUSP00000123875.2, ENSMUST00000159955.2
    Conserved Domains (5) summary
    smart00180
    Location:478 → 528
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:530 → 579
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    TIGR02168
    Location:830 → 1161
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00053
    Location:376 → 425
    Laminin_EGF; Laminin EGF domain
    cl02806
    Location:20 → 248
    Laminin_N; Laminin N-terminal (Domain VI)

  2. NM_008484.2 → NP_032510.2  laminin subunit beta-3 precursor

    See identical proteins and their annotated locations for NP_032510.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC022675, AK078970, BY098011, BY101470, BY248755, CK023039, CX237661
    Consensus CDS
    CCDS15637.1
    UniProtKB/Swiss-Prot
    Q61087, Q91V90
    Related
    ENSMUSP00000016315.10, ENSMUST00000016315.16
    Conserved Domains (5) summary
    smart00180
    Location:478 → 528
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:530 → 579
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    TIGR02168
    Location:830 → 1161
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00053
    Location:376 → 425
    Laminin_EGF; Laminin EGF domain
    cl02806
    Location:20 → 248
    Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    192976661..193026186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497233.2 → XP_006497296.1  laminin subunit beta-3 isoform X1

    See identical proteins and their annotated locations for XP_006497296.1

    UniProtKB/Swiss-Prot
    Q61087, Q91V90
    Related
    ENSMUSP00000142053.2, ENSMUST00000194677.6
    Conserved Domains (5) summary
    smart00180
    Location:478 → 528
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:530 → 579
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    TIGR02168
    Location:830 → 1161
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00053
    Location:376 → 425
    Laminin_EGF; Laminin EGF domain
    cl02806
    Location:20 → 248
    Laminin_N; Laminin N-terminal (Domain VI)

  2. XM_006497232.1 → XP_006497295.1  laminin subunit beta-3 isoform X1

    See identical proteins and their annotated locations for XP_006497295.1

    UniProtKB/Swiss-Prot
    Q61087, Q91V90
    Conserved Domains (5) summary
    smart00180
    Location:478 → 528
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:530 → 579
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    TIGR02168
    Location:830 → 1161
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00053
    Location:376 → 425
    Laminin_EGF; Laminin EGF domain
    cl02806
    Location:20 → 248
    Laminin_N; Laminin N-terminal (Domain VI)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61087.2 GenPept UniProtKB/Swiss-Prot:Q61087

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