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Lag3 lymphocyte-activation gene 3 [ Mus musculus (house mouse) ]

Gene ID: 16768, updated on 23-Mar-2024

Summary

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Official Symbol
Lag3provided by MGI
Official Full Name
lymphocyte-activation gene 3provided by MGI
Primary source
MGI:MGI:106588
See related
Ensembl:ENSMUSG00000030124 AllianceGenome:MGI:106588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly66; CD223; LAG-3
Summary
Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in negative regulation of regulatory T cell differentiation; plasmacytoid dendritic cell activation; and regulation of immune response. Acts upstream of or within cell surface receptor signaling pathway; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 7.2), spleen adult (RPKM 4.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Lag3 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124881322..124888668, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124904359..124912434, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124812982-124813183 Neighboring gene G protein-coupled receptor 162 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124814119-124814302 Neighboring gene CD4 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124829493-124829732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124836126-124836313 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124850419-124850700 Neighboring gene STARR-positive B cell enhancer ABC_E4863 Neighboring gene STARR-positive B cell enhancer ABC_E1710 Neighboring gene RIKEN cDNA A230083G16 gene Neighboring gene STARR-seq mESC enhancer starr_17314 Neighboring gene parathymosin Neighboring gene predicted gene, 38896

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Signatures of glial activity can be detected in the CSF proteome. Eninger T, et al. Proc Natl Acad Sci U S A, 2022 Jun 14. PMID 35666874, Free PMC Article
  2. Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. Maruhashi T, et al. Immunity, 2022 May 10. PMID 35413245
  3. Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function. Garcia Cruz D, et al. J Immunol, 2021 Nov 1. PMID 34588222, Free PMC Article
  4. Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity. Rudd CE, et al. Cell Rep, 2020 Feb 18. PMID 32075731
  5. Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma. Tian D, et al. Nat Commun, 2019 Sep 18. PMID 31534137, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function.
    Title: Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function.
  2. Cerebral Microvascular Injury Induced by Lag3-Dependent alpha-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of alpha-Synucleinopathies.
    Title: Cerebral Microvascular Injury Induced by Lag3-Dependent α-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α-Synucleinopathies.
  3. [LAG3 intracytoplasmic acidic environment locally disrupts the association of the Lck kinase to CD4 and CD8, two co-receptors of the TCR].
    Title: [LAG3 intracytoplasmic acidic environment locally disrupts the association of the Lck kinase to CD4 and CD8, two co-receptors of the TCR].
  4. LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.
    Title: LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.
  5. Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity.
    Title: Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity.
  6. T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice.
    Title: T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice.
  7. Mechanistic basis for receptor-mediated pathological alpha-synuclein fibril cell-to-cell transmission in Parkinson's disease.
    Title: Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.
  8. Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.
    Title: Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.
  9. LAG3 is not expressed in human and murine neurons and does not modulate alpha-synucleinopathies.
    Title: LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
  10. Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
    Title: Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables MHC class II protein binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of interleukin-2 production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasmacytoid dendritic cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of immune response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lymphocyte activation gene 3 protein
Names
activation-induced cytidine deaminase-linked autoimmunity protein
aida

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008479.2 → NP_032505.1  lymphocyte activation gene 3 protein precursor

    See identical proteins and their annotated locations for NP_032505.1

    Status: VALIDATED

    Source sequence(s)
    AC142254, BC120591, CO040235
    Consensus CDS
    CCDS20536.1
    UniProtKB/Swiss-Prot
    Q0VBL2, Q61790
    Related
    ENSMUSP00000032217.2, ENSMUST00000032217.2
    Conserved Domains (3) summary
    smart00410
    Location:261 → 344
    IG_like; Immunoglobulin like
    pfam00047
    Location:168 → 246
    ig; Immunoglobulin domain
    cl11960
    Location:261 → 344
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124881322..124888668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61790.1 GenPept UniProtKB/Swiss-Prot:Q61790

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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