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Krt32 keratin 32 [ Mus musculus (house mouse) ]

Gene ID: 16670, updated on 5-Mar-2024

Summary

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Official Symbol
Krt32provided by MGI
Official Full Name
keratin 32provided by MGI
Primary source
MGI:MGI:1309995
See related
Ensembl:ENSMUSG00000046095 AllianceGenome:MGI:1309995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ha3; K32; Hka2; Krt1-2; Krtha2
Summary
Predicted to enable structural molecule activity. Predicted to be located in intermediate filament. Is expressed in esophagus; jaw bone; lung; skin; and urethra. Orthologous to human KRT32 (keratin 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 3.1), stomach adult (RPKM 1.0) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 63.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99971674..99979095, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100080848..100088269, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 34 Neighboring gene keratin 31 Neighboring gene predicted gene 11571 Neighboring gene STARR-seq mESC enhancer starr_30712 Neighboring gene keratin 35 Neighboring gene keratin 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation. Meier N, et al. Mech Dev, 1999 Dec. PMID 10559501
  2. Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice. Talbot D, et al. J Invest Dermatol, 1999 Nov. PMID 10571739
  3. Sequence and expression of murine type I hair keratins mHa2 and mHa3. Winter H, et al. Exp Cell Res, 1994 Jun. PMID 7514534
  4. Quantitative trait loci for steady-state platelet count in mice. Cheung CC, et al. Mamm Genome, 2004 Oct. PMID 15520881
  5. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Huelsken J, et al. Cell, 2001 May 18. PMID 11371349

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144672, MGC144673

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin, type I cuticular Ha2
Names
hair keratin, type I Ha2
keratin complex 1, acidic, gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159374.3 → NP_001152846.2  keratin, type I cuticular Ha2

    Status: VALIDATED

    Source sequence(s)
    AL662808
    Consensus CDS
    CCDS56805.1
    UniProtKB/Swiss-Prot
    Q148N4, Q62168
    UniProtKB/TrEMBL
    B1ATJ5
    Related
    ENSMUSP00000103042.2, ENSMUST00000107419.3
    Conserved Domains (3) summary
    pfam00038
    Location:100 → 411
    Filament; Intermediate filament protein
    pfam05287
    Location:1 → 92
    PMG; PMG protein
    pfam16043
    Location:102 → 256
    DUF4795; Domain of unknown function (DUF4795)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    99971674..99979095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010665.2: Suppressed sequence

    Description
    NM_010665.2: This RefSeq was temporarily suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62168.2 GenPept UniProtKB/Swiss-Prot:Q62168

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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