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Krt13 keratin 13 [ Mus musculus (house mouse) ]

Gene ID: 16663, updated on 5-Mar-2024

Summary

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Official Symbol
Krt13provided by MGI
Official Full Name
keratin 13provided by MGI
Primary source
MGI:MGI:101925
See related
Ensembl:ENSMUSG00000044041 AllianceGenome:MGI:101925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K13; CK13; Krt1-13; Krt-1.13
Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in lung adult (RPKM 380.7) and stomach adult (RPKM 364.4) See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 63.41 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100008153..100012392, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100117327..100121566, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 35 Neighboring gene STARR-seq mESC enhancer starr_30712 Neighboring gene keratin 36 Neighboring gene keratin 15 Neighboring gene keratin 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal carcinoma by downregulating the MEK/ERK pathway. Shi M, et al. IUBMB Life, 2022 Jun. PMID 35426961
  2. Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice. Ahmad A, et al. Cancer Biol Ther, 2010 Nov 15. PMID 20818173, Free PMC Article
  3. Retinoic acid-induced normal and tumor-associated aberrant expression of the murine keratin K13 gene does not involve a promotor sequence with striking homology to a natural retinoic acid responsive element. Winter H, et al. Carcinogenesis, 1994 Nov. PMID 7525098
  4. Tissue-specific expression of murine keratin K13 in internal stratified squamous epithelia and its aberrant expression during two-stage mouse skin carcinogenesis is associated with the methylation state of a distinct CpG site in the remote 5'-flanking region of the gene. Winter H, et al. Differentiation, 1990 Apr. PMID 1695590
  5. The glossopharyngeal nerve controls epithelial expression of Sprr2a and Krt13 around taste buds in the circumvallate papilla. Miura H, et al. Neurosci Lett, 2014 Sep 19. PMID 25123441

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal carcinoma by downregulating the MEK/ERK pathway.
    Title: Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal carcinoma by downregulating the MEK/ERK pathway.
  2. Keratin 13 deficiency causes white sponge nevus in mice.
    Title: Keratin 13 deficiency causes white sponge nevus in mice.
  3. denervation caused an increase of Keratin (Krt)13 expression around taste buds
    Title: The glossopharyngeal nerve controls epithelial expression of Sprr2a and Krt13 around taste buds in the circumvallate papilla.
  4. K13 cooperates with Myc to promote lymphoma through elevated NF-kappaB.
    Title: Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
keratin, type I cytoskeletal 13
Names
47 kDa cytokeratin
CK-13
cytokeratin 13
keratin complex 1, acidic, gene 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313949.1 → NP_001300878.1  keratin, type I cytoskeletal 13 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK132640, BQ561384, EH100895
    UniProtKB/Swiss-Prot
    P08730
    Conserved Domains (1) summary
    pfam00038
    Location:1 → 189
    Filament; Intermediate filament protein

  2. NM_010662.2 → NP_034792.1  keratin, type I cytoskeletal 13 isoform 1

    See identical proteins and their annotated locations for NP_034792.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK132640, EH100895
    Consensus CDS
    CCDS25409.1
    UniProtKB/Swiss-Prot
    P08730, Q3V176, Q6PAI1
    Related
    ENSMUSP00000007275.3, ENSMUST00000007275.3
    Conserved Domains (1) summary
    pfam00038
    Location:95 → 407
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100008153..100012392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08730.2 GenPept UniProtKB/Swiss-Prot:P08730

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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