Kpna2 karyopherin subunit alpha 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kpna2provided by MGI
Official Full Name: karyopherin subunit alpha 2provided by MGI
Primary source: MGI:MGI:103561
See related: Ensembl:ENSMUSG00000018362 AllianceGenome:MGI:103561
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rch1; IPOA1; PTAC58; 2410044B12Rik
Summary: Enables DNA-binding transcription factor binding activity and nuclear import signal receptor activity. Acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of viral life cycle; and protein import into nucleus. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 144.8), liver E14 (RPKM 99.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 70.08 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (106879455..106890351, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (106988629..106999525, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinalpha1/KPNA2.
Title: Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2.
KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation.
Title: KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation.
Importin alpha2 association with chromatin: Direct DNA binding via a novel DNA-binding domain.
Title: Importin α2 association with chromatin: Direct DNA binding via a novel DNA-binding domain.
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
Title: USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
NLRP3 interacted with Kpna2 and translocated to the nucleus from the cytoplasm under regulatory T cells-polarizing conditions.
Title: NLRP3 negatively regulates Treg differentiation through Kpna2-mediated nuclear translocation.
upregulation of KPNA2 seemed to be correlated with progression of the degree of atypia in pancreatic ductal cells in aged diabetic C414A-mutant-CRY1 transgenic mice
Title: Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice.
Results demonstrated that radiation-induced dying colorectal cancer cells released considerable amounts of KPNA2 that induce the maturation and activation of DCs for synergistic antitumor effect of radiation.
Title: Induction of immunogenic cell death by radiation-upregulated karyopherin alpha 2 in vitro.
mTORC1 positively regulated the importer protein KPNA2, which participated in glycolysis regulation downstream of mTORC1 in a HIF1alpha-independent manner, indicating that mTORC1 regulates glycolysis through multiple ways.
Title: mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances.
provided support for a link between autophagy and epithelial-to-mesenchymal (-like) transition status in WT TP53 glioblastoma cells and provided evidence for the signaling pathway (MIR517C-KPNA2-cytoplasmic TP53) involved in attenuating autophagy
Title: MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation.
Structure of importin-alpha bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein has been reported.
Title: Structure of importin-α bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC109067P1 (e-PCR)
- UniSTS:270152

Kpna2 (e-PCR), detects polymorphism
- UniSTS:143721

UniSTS:143722 (e-PCR)
- UniSTS:143722

Kpna2 (e-PCR), detects polymorphism
- UniSTS:143722

Kpna2 (e-PCR), detects polymorphism
- UniSTS:545951

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in NLS-bearing protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of viral life cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of viral life cycle	ISO Inferred from Sequence Orthology more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: importin subunit alpha-1

Names: RAG cohort protein 1; SRP1-alpha; importin alpha 1; importin alpha P1; importin subunit alpha-2; karyopherin (importin) alpha 2; m-importin-alpha-P1; pendulin; pore targeting complex 58 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010655.3 → NP_034785.1 importin subunit alpha-1

See identical proteins and their annotated locations for NP_034785.1

Status: VALIDATED

Source sequence(s)

AI664586, AK075952, BC086789

Consensus CDS

CCDS25565.1

UniProtKB/Swiss-Prot

P52293, Q64292

UniProtKB/TrEMBL

Q52L97, Q641N9

Related

ENSMUSP00000018506.7, ENSMUST00000018506.13

Conserved Domains (6) summary

COG5064
Location:9 → 528

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

cd00020
Location:113 → 238

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam01749
Location:10 → 98

IBB; Importin beta binding domain

pfam16186
Location:458 → 508

Arm_3; Atypical Arm repeat

sd00044
Location:457 → 494

HEAT; HEAT repeat [structural motif]

sd00043
Location:115 → 147

ARM; armadillo repeat [structural motif]