Serpina3c serine (or cysteine) peptidase inhibitor, clade A, member 3C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpina3cprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 3Cprovided by MGI
Primary source: MGI:MGI:102848
See related: Ensembl:ENSMUSG00000066361 AllianceGenome:MGI:102848
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1A1; spi2; Kalbp; Klkbp
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 46.6), genital fat pad adult (RPKM 27.6) and 4 other tissues See more
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Genomic context

Location:: 12 E; 12 53.46 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (104113166..104120187, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (104146907..104153929, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway.
Title: SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway.
Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through beta-catenin/Foxo1/TLR4 signaling.
Title: Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through β-catenin/Foxo1/TLR4 signaling.
Serpina3c regulates adipose differentiation via the Wnt/beta-catenin-PPARgamma pathway.
Title: Serpina3c regulates adipose differentiation via the Wnt/β-catenin-PPARγ pathway.
This study demonstrated that kallistatin expression is repressed by triiodothyronine and modulated by the orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1).
Title: Thyroid hormone and COUP-TF1 regulate kallikrein-binding protein (KBP) gene expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cytokine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease inhibitor A3C

Names: KBP; alpha-1 antiproteinase; kallikrein-binding protein; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3C; serine (or cysteine) proteinase inhibitor, clade A, member 3C; serpin A3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008458.2 → NP_032484.1 serine protease inhibitor A3C precursor

See identical proteins and their annotated locations for NP_032484.1

Status: PROVISIONAL

Source sequence(s)

AC142112

Consensus CDS

CCDS26148.1

UniProtKB/Swiss-Prot

P29621

UniProtKB/TrEMBL

Q14AS7

Related

ENSMUSP00000082125.4, ENSMUST00000085050.4

Conserved Domains (1) summary

cd02056
Location:51 → 411

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

104113166..104120187 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244002.4 → XP_011242304.1 serine protease inhibitor A3C isoform X1

UniProtKB/TrEMBL

Q14AS7

Conserved Domains (1) summary

cd19551
Location:56 → 434

serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin