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Kcns2 K+ voltage-gated channel, subfamily S, 2 [ Mus musculus (house mouse) ]

Gene ID: 16539, updated on 21-Apr-2024

Summary

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Official Symbol
Kcns2provided by MGI
Official Full Name
K+ voltage-gated channel, subfamily S, 2provided by MGI
Primary source
MGI:MGI:1197011
See related
Ensembl:ENSMUSG00000050963 AllianceGenome:MGI:1197011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv9.2; E130006J24Rik
Summary
Predicted to enable voltage-gated potassium channel activity. Involved in potassium ion transport and regulation of delayed rectifier potassium channel activity. Located in perinuclear region of cytoplasm and plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in diencephalon lateral wall mantle layer; heart; and olfactory epithelium. Orthologous to human KCNS2 (potassium voltage-gated channel modifier subfamily S member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.7), frontal lobe adult (RPKM 2.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.1; 15 14.34 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34837501..34843553)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34837355..34843407)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53873 Neighboring gene predicted gene, 53874 Neighboring gene predicted gene, 32970 Neighboring gene predicted gene, 53875 Neighboring gene STARR-seq mESC enhancer starr_38332 Neighboring gene STARR-seq mESC enhancer starr_38333 Neighboring gene STARR-seq mESC enhancer starr_38334 Neighboring gene STARR-seq mESC enhancer starr_38335 Neighboring gene STARR-seq mESC enhancer starr_38336 Neighboring gene serine/threonine kinase 3 Neighboring gene predicted gene, 52204 Neighboring gene STARR-seq mESC enhancer starr_38337 Neighboring gene STARR-seq mESC enhancer starr_38338 Neighboring gene predicted gene, 52178 Neighboring gene predicted gene, 33497

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, et al. J Biol Chem, 1997 Sep 26. PMID 9305895
  2. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
potassium voltage-gated channel subfamily S member 2
Names
delayed-rectifier K(+) channel alpha subunit 2
voltage-gated potassium channel subunit Kv9.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271704.1 → NP_001258633.1  potassium voltage-gated channel subfamily S member 2

    See identical proteins and their annotated locations for NP_001258633.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK039387, AK050926, BC059833, BE954026
    Consensus CDS
    CCDS27421.1
    UniProtKB/Swiss-Prot
    O35174, Q543P3
    UniProtKB/TrEMBL
    Q69ZQ8
    Related
    ENSMUSP00000153984.2, ENSMUST00000228725.2
    Conserved Domains (2) summary
    pfam00520
    Location:186 → 421
    Ion_trans; Ion transport protein
    pfam02214
    Location:19 → 118
    BTB_2; BTB/POZ domain

  2. NM_181317.4 → NP_851834.1  potassium voltage-gated channel subfamily S member 2

    See identical proteins and their annotated locations for NP_851834.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK050926, AK173110, BE954026
    Consensus CDS
    CCDS27421.1
    UniProtKB/Swiss-Prot
    O35174, Q543P3
    UniProtKB/TrEMBL
    Q69ZQ8
    Related
    ENSMUSP00000072645.4, ENSMUST00000072868.5
    Conserved Domains (2) summary
    pfam00520
    Location:186 → 421
    Ion_trans; Ion transport protein
    pfam02214
    Location:19 → 118
    BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    34837501..34843553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_008436.1: Suppressed sequence

    Description
    NM_008436.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35174.1 GenPept UniProtKB/Swiss-Prot:O35174

Gene LinkOut

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