Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnmb1provided by MGI
Official Full Name: potassium large conductance calcium-activated channel, subfamily M, beta member 1provided by MGI
Primary source: MGI:MGI:1334203
See related: Ensembl:ENSMUSG00000020155 AllianceGenome:MGI:1334203
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BKbeta1
Summary: Enables calcium-activated potassium channel activity. Predicted to be involved in several processes, including cellular response to bile acid; cellular response to ethanol; and detection of calcium ion. Predicted to act upstream of or within ion transport. Is integral component of membrane. Part of voltage-gated potassium channel complex. Is expressed in arterial system; sensory organ; skeleton; and tarsus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 14.4), ovary adult (RPKM 3.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 19.32 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (33912955..33923641)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (33962955..33973641)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.
Title: Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.
Knockout of AKAP150 improves impaired BK channel-mediated vascular dysfunction through the Akt/GSK3beta signalling pathway in diabetes mellitus.
Title: Knockout of AKAP150 improves impaired BK channel-mediated vascular dysfunction through the Akt/GSK3β signalling pathway in diabetes mellitus.
Compromised PASMC beta1 function may contribute to the heightened microvascular vasoconstriction that characterizes pulmonary hypertension.
Title: β1-Subunit of the calcium-sensitive potassium channel modulates the pulmonary vascular smooth muscle cell response to hypoxia.
Whole-cell currents density of BK channels and amplitude of spontaneous transient outward currents were significantly reduced in hypoxia vascular myocytes.
Title: Chronic Prenatal Hypoxia Down-Regulated BK Channel Β1 Subunits in Mesenteric Artery Smooth Muscle Cells of the Offspring.
Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2+) channels, leading to Ca(2+) influx and the activation of Rho kinase (ROCK) 1 and 2.
Title: Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction.
Expression of vascular large-conductance calcium-activated potassium channel Kcnmb1 is regulated by Nrf2 signaling.
Title: Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling.
7-Ketocholesterol induces the reduction of KCNMB1 through the AhR pathway.
Title: 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels.
BK channel activity directly affects vascular tone but influences blood pressure independent of this effect via different pathways
Title: Smooth muscle BK channel activity influences blood pressure independent of vascular tone in mice.
up-regulation of NF-kappaB-dependent MuRF1 expression is a novel mechanism that leads to BK channelopathy and vasculopathy in diabetes
Title: Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels.
Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa channel remodeling, which contributes to vasoconstriction during diabetes mellitus.
Title: AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236551

AF020711 (e-PCR)
- UniSTS:160081

D11Mit173 (e-PCR), detects polymorphism
- UniSTS:126368

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-activated potassium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to bile acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in detection of calcium ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: calcium-activated potassium channel subunit beta-1

Names: BK channel beta subunit; BK channel subunit beta-1; BKbeta; calcium-activated potassium channel subunit beta; calcium-activated potassium channel, subfamily M subunit beta-1; charybdotoxin receptor subunit beta-1; k(VCA)beta-1; maxi K channel subunit beta-1; slo-beta; slo-beta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031169.4 → NP_112446.2 calcium-activated potassium channel subunit beta-1

See identical proteins and their annotated locations for NP_112446.2

Status: VALIDATED

Source sequence(s)

AF020711, AK038987, AK039715, AL731867, AU043056, BB196456

Consensus CDS

CCDS24538.1

UniProtKB/TrEMBL

Q5SQK1

Related

ENSMUSP00000020362.3, ENSMUST00000020362.3

Conserved Domains (1) summary

pfam03185
Location:7 → 190

CaKB; Calcium-activated potassium channel, beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

33912955..33923641

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514541.4 → XP_006514604.1 calcium-activated potassium channel subunit beta-1 isoform X1

See identical proteins and their annotated locations for XP_006514604.1

UniProtKB/TrEMBL

Q5SQK1

Conserved Domains (1) summary

pfam03185
Location:7 → 190

CaKB; Calcium-activated potassium channel, beta subunit