U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 [ Mus musculus (house mouse) ]

Gene ID: 16519, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Kcnj3provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 3provided by MGI
Primary source
MGI:MGI:104742
See related
Ensembl:ENSMUSG00000026824 AllianceGenome:MGI:104742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GIRK1; Kcnf3; Kcnj1; GIRK-1; Kir3.1
Summary
Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to act upstream of or within ion transport. Is active in parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; male reproductive gland or organ; and thymus. Orthologous to human KCNJ3 (potassium inwardly rectifying channel subfamily J member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 9.5), heart adult (RPKM 8.9) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kcnj3 in Genome Data Viewer
Location:
2 C1.1; 2 31.66 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (55301814..55488157)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (55411798..55598145)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 13 Neighboring gene predicted gene, 25489 Neighboring gene STARR-seq mESC enhancer starr_04517 Neighboring gene STARR-seq mESC enhancer starr_04518 Neighboring gene STARR-positive B cell enhancer mm9_chr2:55104656-55104956 Neighboring gene cathepsin B pseudogene Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene oral-facial-digital syndrome 1 gene homolog pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice. Djebari S, et al. J Neurosci, 2021 Aug 18. PMID 34261700, Free PMC Article
  2. Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice. Anderson EM, et al. Neuropsychopharmacology, 2021 Nov. PMID 34158613, Free PMC Article
  3. GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation. Lippiello P, et al. Cerebellum, 2020 Dec. PMID 32617840
  4. VU0810464, a non-urea G protein-gated inwardly rectifying K(+) (K(ir) 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K(ir) 3 channels and reduces stress-induced hyperthermia in mice. Vo BN, et al. Br J Pharmacol, 2019 Jul. PMID 30924523, Free PMC Article
  5. Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy. Toyama Y, et al. Proc Natl Acad Sci U S A, 2018 Apr 10. PMID 29581303, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice.
    Title: G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice.
  2. Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.
    Title: Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.
  3. GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation.
    Title: GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation.
  4. Genetic Loss of IK1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia.
    Title: Genetic Loss of I(K1) Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia.
  5. Ethanol activates GIRK1 by shifting the conformational equilibrium processes, which are responsible for the gating of GIRK, to stabilize an open conformation of the cytoplasmic ion gate.
    Title: Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy.
  6. histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2, Kcnj3, Kcnj5, Kcnj11, and Kcnh2)
    Title: Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells.
  7. Kir 3.1 channels are important for supraspinal antinociception and presynaptic GABA release inhibition by oxycodone in the femur bone cancer model
    Title: Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model.
  8. GABA neurons in the ventral tegmental area express GIRK1 (and GIRK2) subunits.
    Title: GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner.
  9. K(IR)3.1 channels play a primary role in the antinociceptive effects of oxycodone, but not those of morphine, at supraspinal sites and suggest that supraspinal K(IR)3.1 channels are responsible for the unique analgesic profile of oxycodone.
    Title: G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.
  10. siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1.
    Title: Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC124233, MGC124234

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein activated inward rectifier potassium channel activity TAS
Traceable Author Statement
more info
 PubMed 
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G protein-activated inward rectifier potassium channel 1
Names
G protein-gated K+ channel subunit 1 GIRK1
inward rectifier K(+) channel Kir3.1
potassium channel, inwardly rectifying subfamily J member 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304810.1 → NP_001291739.1  G protein-activated inward rectifier potassium channel 1 isoform 2

    See identical proteins and their annotated locations for NP_001291739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL929253, AW488293, BC068167
    Consensus CDS
    CCDS84524.1
    UniProtKB/TrEMBL
    B1AYE4, Q8VHS4
    Related
    ENSMUSP00000108251.2, ENSMUST00000112632.2
    Conserved Domains (1) summary
    cl21560
    Location:47 → 234
    Ion_trans_2; Ion channel

  2. NM_001355118.1 → NP_001342047.1  G protein-activated inward rectifier potassium channel 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL845483, AL929253
    Consensus CDS
    CCDS16042.1
    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  3. NM_008426.2 → NP_032452.1  G protein-activated inward rectifier potassium channel 1 isoform 1

    See identical proteins and their annotated locations for NP_032452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL929253, AW488293, BC068167
    Consensus CDS
    CCDS16042.1
    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Related
    ENSMUSP00000063329.4, ENSMUST00000067101.10
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    55301814..55488157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247723.2 → XP_030103583.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. XM_036158746.1 → XP_036014639.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  3. XM_030247737.2 → XP_030103597.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  4. XM_030247725.2 → XP_030103585.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  5. XM_030247736.2 → XP_030103596.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  6. XM_030247738.2 → XP_030103598.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  7. XM_030247730.2 → XP_030103590.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  8. XM_030247739.2 → XP_030103599.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  9. XM_030247729.2 → XP_030103589.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  10. XM_030247740.2 → XP_030103600.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  11. XM_036158749.1 → XP_036014642.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  12. XM_030247752.2 → XP_030103612.1  G protein-activated inward rectifier potassium channel 1 isoform X3

    Conserved Domains (1) summary
    pfam17655
    Location:2 → 132
    IRK_C; Inward rectifier potassium channel C-terminal domain

  13. XM_030247722.2 → XP_030103582.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  14. XM_030247751.2 → XP_030103611.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  15. XM_030247749.2 → XP_030103609.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 364
    IRK_C; Inward rectifier potassium channel C-terminal domain

  16. XM_006497731.5 → XP_006497794.1  G protein-activated inward rectifier potassium channel 1 isoform X2

    UniProtKB/TrEMBL
    Q8VHS4
    Conserved Domains (2) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194 → 240
    IRK_C; Inward rectifier potassium channel C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63250.1 GenPept UniProtKB/Swiss-Prot:P63250

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous