Cuzd1 CUB and zona pellucida-like domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cuzd1provided by MGI
Official Full Name: CUB and zona pellucida-like domains 1provided by MGI
Primary source: MGI:MGI:1202881
See related: Ensembl:ENSMUSG00000040205 AllianceGenome:MGI:1202881
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Usg; Erg-1; Uo-44; Utczp; Itmap1
Summary: Involved in trypsinogen activation. Located in zymogen granule membrane. Orthologous to human CUZD1 (CUB and zona pellucida like domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 834.5) See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 73.81 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (130910283..130924021, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (131308554..131322292, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that overexpression of Cuzd1, regulator of growth factor signaling pathways controlled by PRLR and STAT5, promotes tumorigenesis in mammary epithelial cells. (Cuzd1 = Cub and zona pellucida-like domain-containing protein-1; Prlr = prolactin receptor; Stat5 = signal transducer and activator of transcription-5)
Title: Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis.
Data show that CUZD1 interacts with a complex containing JAK1/JAK2 and STAT5, downstream transducers of prolactin signaling in the mammary gland.
Title: CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy.
ERG-1 mediates SiO(2)-driven transcription of Mmp14 in macrophages.
Title: Egr-1 mediates Si0(2)-driven transcription of membrane type I matrix metalloproteinase in macrophages.
plays an essential role in trypsinogen activation and both impaired and augmented trypsinogen activation can be associated with increased severity of pancreatitis
Title: Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	NAS Non-traceable Author Statement more info	PubMed
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in trypsinogen activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in zymogen granule	IDA Inferred from Direct Assay more info	PubMed
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CUB and zona pellucida-like domain-containing protein 1

Names: CUB and ZP domain-containing protein 1; integral membrane-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008411.3 → NP_032437.3 CUB and zona pellucida-like domain-containing protein 1 precursor

See identical proteins and their annotated locations for NP_032437.3

Status: VALIDATED

Source sequence(s)

AC110885, AC156606, BY707834, BY707920

Consensus CDS

CCDS40157.1

UniProtKB/Swiss-Prot

B2RU69, P70412, Q9CTZ7

Related

ENSMUSP00000037168.8, ENSMUST00000046611.9

Conserved Domains (4) summary

smart00042
Location:55 → 143

CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein

smart00241
Location:277 → 519

ZP; Zona pellucida (ZP) domain

pfam00100
Location:400 → 517

Zona_pellucida; Zona pellucida-like domain

pfam00431
Location:154 → 262

CUB; CUB domain