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Itga7 integrin alpha 7 [ Mus musculus (house mouse) ]

Gene ID: 16404, updated on 3-Apr-2024

Summary

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Official Symbol
Itga7provided by MGI
Official Full Name
integrin alpha 7provided by MGI
Primary source
MGI:MGI:102700
See related
Ensembl:ENSMUSG00000025348 AllianceGenome:MGI:102700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
[a]7; alpha7
Summary
This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded transmembrane protein is the alpha subunit that forms a noncovalent heterodimer with the beta subunit to form the functional integrin receptor that binds to laminin. Mice lacking the encoded protein exhibit symptoms of progressive muscular dystrophy, impaired axonal regeneration and cerebral vascular defects. [provided by RefSeq, Aug 2016]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 28.3), heart adult (RPKM 26.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Itga7 in Genome Data Viewer
Location:
10 D3; 10 77.2 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128769633..128794155)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128933421..128958286)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2975 Neighboring gene CD63 antigen Neighboring gene STARR-positive B cell enhancer ABC_E6941 Neighboring gene retinol dehydrogenase 5 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene predicted gene, 25494 Neighboring gene thiol methyltransferase 1B Neighboring gene RIKEN cDNA 9030616G12 gene Neighboring gene olfactory receptor family 10 subfamily P member 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease. Han S, et al. Int J Mol Sci, 2022 May 18. PMID 35628462, Free PMC Article
  2. α(7)β(1) Integrin regulation of gene transcription in skeletal muscle following an acute bout of eccentric exercise. Mahmassani ZS, et al. Am J Physiol Cell Physiol, 2017 May 1. PMID 28274919, Free PMC Article
  3. Olfactory Ensheathing Cells Express α7 Integrin to Mediate Their Migration on Laminin. Ingram NT, et al. PLoS One, 2016. PMID 27078717, Free PMC Article
  4. Eccentric exercise facilitates mesenchymal stem cell appearance in skeletal muscle. Valero MC, et al. PLoS One, 2012. PMID 22253772, Free PMC Article
  5. The α7β1-integrin accelerates fiber hypertrophy and myogenesis following a single bout of eccentric exercise. Lueders TN, et al. Am J Physiol Cell Physiol, 2011 Oct. PMID 21753185

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse hippocampal neurons.
    Title: Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of α7 versus α3β4 nicotinic receptor subtypes in mouse hippocampal neurons.
  2. Integrin alpha7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.
    Title: Integrin α7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.
  3. Association between Decreased ITGA7 Levels and Increased Muscle alpha-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.
    Title: Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.
  4. ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.
    Title: ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.
  5. Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7).
    Title: Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7).
  6. miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
    Title: miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
  7. Ptrh2 levels were up-regulated in dystrophin deficient mdx muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx muscle and Duchenne muscular dystrophy patients. Similar to the a7 integrin, Ptrh2 expression was decreased in laminin-a2 null gastrocnemius muscle
    Title: PTRH2 gene mutation causes progressive congenital skeletal muscle pathology.
  8. Deletion of integrin alpha7 subunit does not aggravate the phenotype of laminin alpha2 chain-deficient mice. laminin-211 and integrin alpha7beta1 have intersecting roles in skeletal muscle.
    Title: Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.
  9. Sarcospan-mediated amelioration of muscular dystrophy in mouse model is dependent on the presence of both utrophin and alpha7beta1 integrin.
    Title: Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin.
  10. loss of alpha7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice
    Title: Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to laminin binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to laminin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin alpha7-beta1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin alpha7-beta1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in muscle tendon junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
integrin alpha-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330160.2 → NP_001317089.1  integrin alpha-7 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS88118.1
    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    UniProtKB/TrEMBL
    Q3TZS3
    Related
    ENSMUSP00000151960.2, ENSMUST00000218290.2
    Conserved Domains (2) summary
    smart00191
    Location:381 → 433
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:475 → 965
    Integrin_alpha2; Integrin alpha

  2. NM_001406285.1 → NP_001393214.1  integrin alpha-7 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122380

  3. NM_001406286.1 → NP_001393215.1  integrin alpha-7 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122380

  4. NM_001406287.1 → NP_001393216.1  integrin alpha-7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122380

  5. NM_008398.3 → NP_032424.2  integrin alpha-7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032424.2

    Status: VALIDATED

    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS24300.1
    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    UniProtKB/TrEMBL
    G3X9Q1
    Related
    ENSMUSP00000096712.3, ENSMUST00000099112.4
    Conserved Domains (2) summary
    smart00191
    Location:377 → 429
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:471 → 961
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128769633..128794155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244914.2 → XP_030100774.1  integrin alpha-7 isoform X4

    Conserved Domains (2) summary
    smart00191
    Location:214 → 266
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:308 → 798
    Integrin_alpha2; Integrin alpha

  2. XM_006513270.4 → XP_006513333.1  integrin alpha-7 isoform X5

    Conserved Domains (2) summary
    smart00191
    Location:213 → 265
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:307 → 797
    Integrin_alpha2; Integrin alpha

  3. XM_036155649.1 → XP_036011542.1  integrin alpha-7 isoform X6

    Conserved Domains (2) summary
    smart00191
    Location:209 → 261
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:303 → 793
    Integrin_alpha2; Integrin alpha

  4. XM_030244916.2 → XP_030100776.1  integrin alpha-7 isoform X8

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    Conserved Domains (2) summary
    smart00191
    Location:377 → 429
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:471 → 961
    Integrin_alpha2; Integrin alpha

  5. XM_030244915.2 → XP_030100775.1  integrin alpha-7 isoform X7

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    UniProtKB/TrEMBL
    A0A8V5L190
    Related
    ENSMUSP00000159495.1, ENSMUST00000240553.1
    Conserved Domains (2) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:515 → 1005
    Integrin_alpha2; Integrin alpha

  6. XM_017313813.3 → XP_017169302.1  integrin alpha-7 isoform X1

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    Conserved Domains (2) summary
    smart00191
    Location:381 → 433
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:475 → 965
    Integrin_alpha2; Integrin alpha

  7. XM_006513269.5 → XP_006513332.1  integrin alpha-7 isoform X2

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    Conserved Domains (2) summary
    smart00191
    Location:317 → 369
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:411 → 901
    Integrin_alpha2; Integrin alpha

  8. XM_030244913.2 → XP_030100773.1  integrin alpha-7 isoform X3

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    Conserved Domains (2) summary
    smart00191
    Location:313 → 365
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:407 → 897
    Integrin_alpha2; Integrin alpha
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61738.3 GenPept UniProtKB/Swiss-Prot:Q61738

Gene LinkOut

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