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Irf2 interferon regulatory factor 2 [ Mus musculus (house mouse) ]

Gene ID: 16363, updated on 21-Apr-2024

Summary

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Official Symbol
Irf2provided by MGI
Official Full Name
interferon regulatory factor 2provided by MGI
Primary source
MGI:MGI:96591
See related
Ensembl:ENSMUSG00000031627 AllianceGenome:MGI:96591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irf-2; 9830146E22Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to virus; immune system process; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; focal adhesion; and nucleoplasm. Predicted to be active in nucleus. Is expressed in eye; genitourinary system; heart; and limb. Orthologous to human IRF2 (interferon regulatory factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 5.7), colon adult (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B1.1; 8 26.42 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (47192751..47300493)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46739745..46847458)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6636 Neighboring gene predicted gene, 31111 Neighboring gene STARR-seq mESC enhancer starr_21392 Neighboring gene STARR-positive B cell enhancer mm9_chr8:47824808-47825109 Neighboring gene predicted gene, 16675 Neighboring gene VISTA enhancer mm9 Neighboring gene predicted gene, 31172 Neighboring gene STARR-seq mESC enhancer starr_21394 Neighboring gene STARR-positive B cell enhancer ABC_E6637 Neighboring gene STARR-positive B cell enhancer ABC_E10499 Neighboring gene predicted gene, 39170 Neighboring gene STARR-seq mESC enhancer starr_21395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:48005439-48005671 Neighboring gene STARR-positive B cell enhancer ABC_E2864 Neighboring gene STARR-positive B cell enhancer ABC_E5003 Neighboring gene STARR-positive B cell enhancer ABC_E6638 Neighboring gene predicted gene, 53417 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 6 Neighboring gene STARR-seq mESC enhancer starr_21398 Neighboring gene predicted gene, 31231

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The transcription factor IRF2 drives interferon-mediated CD8(+) T cell exhaustion to restrict anti-tumor immunity. Lukhele S, et al. Immunity, 2022 Dec 13. PMID 36370712, Free PMC Article
  2. Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury. He T, et al. Drug Dev Res, 2022 Jun. PMID 35088417
  3. IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis. Li Y, et al. Mol Med Rep, 2022 Feb. PMID 34878155, Free PMC Article
  4. IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling. Kim I, et al. BMB Rep, 2021 Sep. PMID 34488926, Free PMC Article
  5. IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages. Cui H, et al. J Immunol, 2018 May 1. PMID 29563175, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2.
    Title: Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2.
  2. Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury.
    Title: Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury.
  3. IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.
    Title: IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.
  4. IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-kappaB/NFATc1 signaling.
    Title: IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling.
  5. IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon.
    Title: IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon.
  6. Data show that interferon regulatory factor 2 (IRF2), a member of the interferon regulatory factor (IRF) family of transcription factors, was essential for the transcriptional activation of gasdermin-D (GSDMD).
    Title: IRF2 transcriptionally induces GSDMD expression for pyroptosis.
  7. The results point to a unique, cell-type selective role for IRF-2 in Innate lymphoid cells (ILC) development, acting at a discrete step critical for the generation of functionally competent Innate lymphoid cells precursors (ILCPs).
    Title: Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2.
  8. The KRAS( *)-IRF2-CXCL3-CXCR2 axis drives colorectal cancer cell immune suppression and resistance to anti-PD-1 immunotherapy.
    Title: KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
  9. our data suggest that IRF2 is an important regulator of the proinflammatory response in macrophages by controlling HIF-1alpha-dependent glycolytic gene expression and glycolysis.
    Title: IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages.
  10. Data show that HCFC2 is a critical component of the IRF1 and IRF2 transcriptional machinery that regulates Tlr3 gene expression.
    Title: HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117893

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon regulatory factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008391.4 → NP_032417.3  interferon regulatory factor 2

    See identical proteins and their annotated locations for NP_032417.3

    Status: VALIDATED

    Source sequence(s)
    AK036652, AK132099
    Consensus CDS
    CCDS22295.1
    UniProtKB/Swiss-Prot
    P23906
    UniProtKB/TrEMBL
    Q2TAX8, Q3U2Z2, Q923E9
    Related
    ENSMUSP00000034041.8, ENSMUST00000034041.9
    Conserved Domains (1) summary
    pfam00605
    Location:7 → 112
    IRF; Interferon regulatory factor transcription factor

RNA

  1. NR_152560.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116801, AC123751
    Related
    ENSMUST00000210284.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    47192751..47300493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509288.4 → XP_006509351.1  interferon regulatory factor 2 isoform X5

    See identical proteins and their annotated locations for XP_006509351.1

    UniProtKB/Swiss-Prot
    P23906
    UniProtKB/TrEMBL
    Q2TAX8, Q3U2Z2, Q923E9
    Conserved Domains (1) summary
    pfam00605
    Location:7 → 112
    IRF; Interferon regulatory factor transcription factor

  2. XM_011242175.4 → XP_011240477.1  interferon regulatory factor 2 isoform X1

    UniProtKB/TrEMBL
    Q2TAX8, Q923E9
    Conserved Domains (1) summary
    pfam00605
    Location:35 → 140
    IRF; Interferon regulatory factor transcription factor

  3. XM_006509289.5 → XP_006509352.1  interferon regulatory factor 2 isoform X5

    See identical proteins and their annotated locations for XP_006509352.1

    UniProtKB/Swiss-Prot
    P23906
    UniProtKB/TrEMBL
    Q2TAX8, Q3U2Z2, Q923E9
    Conserved Domains (1) summary
    pfam00605
    Location:7 → 112
    IRF; Interferon regulatory factor transcription factor

  4. XM_030243306.2 → XP_030099166.1  interferon regulatory factor 2 isoform X4

    UniProtKB/TrEMBL
    Q2TAX8, Q923E9
    Conserved Domains (1) summary
    pfam00605
    Location:12 → 117
    IRF; Interferon regulatory factor transcription factor

  5. XM_017312580.2 → XP_017168069.1  interferon regulatory factor 2 isoform X3

    UniProtKB/TrEMBL
    Q2TAX8, Q923E9
    Conserved Domains (1) summary
    pfam00605
    Location:28 → 133
    IRF; Interferon regulatory factor transcription factor

  6. XM_030243305.2 → XP_030099165.1  interferon regulatory factor 2 isoform X2

    UniProtKB/TrEMBL
    Q2TAX8, Q923E9
    Conserved Domains (1) summary
    pfam00605
    Location:35 → 140
    IRF; Interferon regulatory factor transcription factor

RNA

  1. XR_001778407.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23906.1 GenPept UniProtKB/Swiss-Prot:P23906

Gene LinkOut

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