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Il7 interleukin 7 [ Mus musculus (house mouse) ]

Gene ID: 16196, updated on 21-Apr-2024

Summary

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Official Symbol
Il7provided by MGI
Official Full Name
interleukin 7provided by MGI
Primary source
MGI:MGI:96561
See related
Ensembl:ENSMUSG00000040329 AllianceGenome:MGI:96561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il-7; hlb368; A630026I06Rik
Summary
The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in thymus adult (RPKM 2.5), spleen adult (RPKM 1.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 A1; 3 2.02 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (7637088..7678820, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (7572028..7613760, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23592 Neighboring gene zinc finger, C2HC-type containing 1A Neighboring gene STARR-seq mESC enhancer starr_06837 Neighboring gene STARR-seq mESC enhancer starr_06838 Neighboring gene STARR-seq mESC enhancer starr_06840 Neighboring gene predicted gene, 16685 Neighboring gene STARR-seq mESC enhancer starr_06841 Neighboring gene STARR-seq mESC enhancer starr_06842 Neighboring gene STARR-seq mESC enhancer starr_06843 Neighboring gene STARR-seq mESC enhancer starr_06844 Neighboring gene STARR-seq mESC enhancer starr_06846 Neighboring gene STARR-seq mESC enhancer starr_06847 Neighboring gene RIKEN cDNA 1700010I02 gene Neighboring gene predicted gene, 29747

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice. Park HJ, et al. Int J Mol Sci, 2023 Jun 9. PMID 37373104, Free PMC Article
  2. Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection. Sheikh A, et al. Sci Rep, 2022 Jan 7. PMID 34997007, Free PMC Article
  3. Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways. Xu A, et al. J Immunol, 2022 Jan 1. PMID 34872976
  4. Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization. Yan M, et al. J Cell Mol Med, 2021 Nov. PMID 34581005, Free PMC Article
  5. Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression. Koyas A, et al. Sci Signal, 2021 Mar 16. PMID 33727336

See all (396) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.
    Title: IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.
  2. Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization.
    Title: Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization.
  3. The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines.
    Title: The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines.
  4. Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.
    Title: Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.
  5. In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells.
    Title: In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells.
  6. Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression.
    Title: Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression.
  7. Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKalpha1-ULK1-ATG7 Pathways.
    Title: Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways.
  8. IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors.
    Title: IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors.
  9. Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.
    Title: Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.
  10. IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
    Title: IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
Submit: New GeneRIF Correction See all GeneRIFs (183)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC129342

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
  
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-7 receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of B cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone resorption IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of organ growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of B cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of organ growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interleukin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313888.1 → NP_001300817.1  interleukin-7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon near the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (b) with a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK040399, AK052452
    Consensus CDS
    CCDS84608.1
    UniProtKB/TrEMBL
    Q3UT18, Q8C9S3
    Related
    ENSMUSP00000141508.2, ENSMUST00000192202.6
    Conserved Domains (1) summary
    cl11602
    Location:1 → 111
    IL7; Interleukin 7/9 family

  2. NM_001313889.1 → NP_001300818.1  interleukin-7 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon near the 5' end and an alternate internal exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (c) with a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK040399, AK042009, AK052452
    Conserved Domains (1) summary
    cl11602
    Location:1 → 102
    IL7; Interleukin 7/9 family

  3. NM_001313890.1 → NP_001300819.1  interleukin-7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains two alternate exons in place of the first exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (b) with a shorter N-terminus, compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AK040399, AK139858
    Consensus CDS
    CCDS84608.1
    UniProtKB/TrEMBL
    Q3UT18, Q8C9S3
    Related
    ENSMUSP00000141827.2, ENSMUST00000194184.6
    Conserved Domains (1) summary
    cl11602
    Location:1 → 111
    IL7; Interleukin 7/9 family

  4. NM_008371.5 → NP_032397.1  interleukin-7 isoform a precursor

    See identical proteins and their annotated locations for NP_032397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK040399, AK041307, AK052452
    Consensus CDS
    CCDS50859.1
    UniProtKB/Swiss-Prot
    P10168
    UniProtKB/TrEMBL
    Q544C8, Q8C9S3
    Related
    ENSMUSP00000141845.2, ENSMUST00000194279.6
    Conserved Domains (1) summary
    smart00127
    Location:27 → 152
    IL7; Interleukin-7 and interleukin-9 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    7637088..7678820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10168.1 GenPept UniProtKB/Swiss-Prot:P10168

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