Il3 interleukin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il3provided by MGI
Official Full Name: interleukin 3provided by MGI
Primary source: MGI:MGI:96552
See related: Ensembl:ENSMUSG00000018914 AllianceGenome:MGI:96552
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BPA; PSF; HCGF; Il-3; MCGF; Csfmu
Summary: Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; monocyte differentiation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed in skin; stomach; thymus; and vascular system. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 32.13 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (54155911..54158105, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (54265085..54267279, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-3-dependent potentiation of IgE responsiveness in mouse basophils.
Title: Interleukin-3-dependent potentiation of IgE responsiveness in mouse basophils.
IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils.
Title: IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils.
IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis.
Title: IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis.
Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.
Title: Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.
JNK signaling during IL-3-mediated differentiation contributes to the c-kit-potentiated allergic inflammatory capacity of mast cells.
Title: JNK signaling during IL-3-mediated differentiation contributes to the c-kit-potentiated allergic inflammatory capacity of mast cells.
Dark pigmentation and related low FMOD expression increase IL-3 and facilitateplasmacytoid dendritic cell maturation.
Title: Dark pigmentation and related low FMOD expression increase IL-3 and facilitateplasmacytoid dendritic cell maturation.
IL-3 regulates the differentiation of pathogenic Th17 cells.
Title: IL-3 regulates the differentiation of pathogenic Th17 cells.
IL-3-Induced Immediate Expression of c-fos and c-jun Is Modulated by the IKK2-JNK Axis.
Title: IL-3-Induced Immediate Expression of c-fos and c-jun Is Modulated by the IKK2-JNK Axis.
An Immunoregulatory Role of Interleukin-3 in Allergic Asthma.
Title: An Immunoregulatory Role of Interleukin-3 in Allergic Asthma.
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Ralpha.
Title: MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (7) 1 citation

General gene information

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Markers

Il3 (e-PCR), detects polymorphism
- UniSTS:257046

NoName (e-PCR)
- UniSTS:493894

K03233 (e-PCR)
- UniSTS:124861

PMC126184P1 (e-PCR)
- UniSTS:270530

Il3 (e-PCR), detects polymorphism
- UniSTS:143561

Il3 (e-PCR), detects polymorphism
- UniSTS:143562

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-3 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-3 receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within activation of Janus kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-3-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of myeloid cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within myeloid cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of myeloid leukocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mast cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of myeloid leukocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of glycolytic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-3

Names: P-cell-stimulating factor; hematopoietic growth factor; mast cell growth factor; multipotential colony-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.