Il12a interleukin 12a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il12aprovided by MGI
Official Full Name: interleukin 12aprovided by MGI
Primary source: MGI:MGI:96539
See related: Ensembl:ENSMUSG00000027776 AllianceGenome:MGI:96539
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p35; Ll12a; Il-12a; IL-12p35
Summary: Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of T cell activation. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 2.9), lung adult (RPKM 1.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E1; 3 31.92 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (68597977..68605881)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (68690644..68698550)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-12alpha deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression.
Title: IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression.
Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation.
Title: Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation.
IL-35 promotes CD4+Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms.
Title: IL-35 promotes CD4+Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms.
A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors.
Title: A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors.
Targeted cytokine delivery: cell therapy to remodel the pre-metastatic niche.
Title: Targeted cytokine delivery: cell therapy to remodel the pre-metastatic niche.
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Title: The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Silencing IL12p35 Promotes Angiotensin II-Mediated Abdominal Aortic Aneurysm through Activating the STAT4 Pathway.
Title: Silencing IL12p35 Promotes Angiotensin II-Mediated Abdominal Aortic Aneurysm through Activating the STAT4 Pathway.
Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis.
Title: Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis.
Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers.
Title: Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers.
Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3.
Title: Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3.

Submit: New GeneRIF Correction See all GeneRIFs (146)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M86672 (e-PCR)
- UniSTS:159124

NoName (e-PCR)
- UniSTS:491244

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to cytokine activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
contributes_to growth factor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-12 beta subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-12 beta subunit binding	ISO Inferred from Sequence Orthology more info
enables interleukin-12 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-27 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T-helper 1 cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T-helper 1 cell cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mononuclear cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in endosome lumen	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of interleukin-12 complex	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-12 complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of interleukin-12 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-12 subunit alpha

Names: CLMF p35; IL-12 p35 subunit; IL-12 subunit p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; interleukin 12a p35 subunit; interleukin-12 p35 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159424.3 → NP_001152896.2 interleukin-12 subunit alpha isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC121306

UniProtKB/Swiss-Prot

P43431

UniProtKB/TrEMBL

Q549G3

Related

ENSMUSP00000029345.6, ENSMUST00000029345.12
NM_001410417.1 → NP_001397346.1 interleukin-12 subunit alpha isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC121306
NM_001410418.1 → NP_001397347.1 interleukin-12 subunit alpha isoform 4

Status: VALIDATED

Source sequence(s)

AC121306
NM_001410419.1 → NP_001397348.1 interleukin-12 subunit alpha isoform 5

Status: VALIDATED

Source sequence(s)

AC121306
NM_001410420.1 → NP_001397349.1 interleukin-12 subunit alpha isoform 5

Status: VALIDATED

Source sequence(s)

AC121306
NM_008351.4 → NP_032377.1 interleukin-12 subunit alpha isoform 2 precursor

See identical proteins and their annotated locations for NP_032377.1

Status: VALIDATED

Source sequence(s)

AC121306

Consensus CDS

CCDS17400.1

UniProtKB/Swiss-Prot

P43431

UniProtKB/TrEMBL

F8WI71, Q549G3

Related

ENSMUSP00000103446.3, ENSMUST00000107816.5

Conserved Domains (1) summary

pfam03039
Location:17 → 215

IL12; Interleukin-12 alpha subunit