Il11ra1 interleukin 11 receptor subunit alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il11ra1provided by MGI
Official Full Name: interleukin 11 receptor subunit alpha 1provided by MGI
Primary source: MGI:MGI:107426
See related: Ensembl:ENSMUSG00000073889 AllianceGenome:MGI:107426
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NR1; GP130; Il11ra; Il-11ra; Il11ra2
Summary: Enables interleukin-11 binding activity and interleukin-11 receptor activity. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; decidualization; and natural killer cell differentiation. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; cranial suture; genitourinary system; immune system; and musculature. Orthologous to human IL11RA (interleukin 11 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 66.0), ovary adult (RPKM 58.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 21.94 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41760443..41769473)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41760443..41769473)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations.
Title: Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations.
Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection.
Title: Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection.
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.
Title: Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.
Colitis-induced IL11 promotes colon carcinogenesis.
Title: Colitis-induced IL11 promotes colon carcinogenesis.
Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease.
Title: Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease.
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
Title: Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
In spite of clear changes in the temporal expression of both IL-11 and its receptor, no significant differences in motor function are found after spinal cord injury.
Title: Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury.
Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
Title: The composition and signaling of the IL-35 receptor are unconventional.
Demyelination and oligodendrocyte death are exacerbated in IL-11 receptor alpha-deficient mice, suggesting avenues to enhance oligodendrocyte viability and restrict central nervous system inflammation in multiple sclerosis.
Title: Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11.
These results provide, at least in part, an explanation for the defective small decidua of mice lacking the Il11ra gene, and reveal for the first time that cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) are targets of IL11 in the decidua.
Title: Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

Il11ra1 (e-PCR), detects polymorphism
- UniSTS:274194

AI314697 (e-PCR)
- UniSTS:178984

Il11ra1 (e-PCR), detects polymorphism
- UniSTS:256824

Il11ra1 (e-PCR), detects polymorphism
- UniSTS:256943

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-11 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-11 binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-11 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-11 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-11 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within decidualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental process	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in head development	ISO Inferred from Sequence Orthology more info
involved_in interleukin-11-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maternal process involved in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-11 receptor subunit alpha-1

Names: IL-11 receptor subunit alpha-1; IL-11R subunit alpha-1; IL-11R-alpha-1; IL-11RA1; Il-11ra-alpha; NR-1; enhancer trap locus homolog 2; etl-2; interleukin 11 receptor, alpha chain 1; interleukin 11 receptor, alpha chain 2; locus 2; novel cytokine receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163401.1 → NP_001156873.1 interleukin-11 receptor subunit alpha-1 precursor

See identical proteins and their annotated locations for NP_001156873.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-3 all encode the same protein.

Source sequence(s)

AK146742, AK159559, BY777524

Consensus CDS

CCDS18071.1

UniProtKB/Swiss-Prot

A2AMS4, Q64385, Q6NSQ0

UniProtKB/TrEMBL

Q3UIV4

Related

ENSMUSP00000095736.5, ENSMUST00000098132.11

Conserved Domains (4) summary

smart00410
Location:33 → 95

IG_like; Immunoglobulin like

cd00063
Location:218 → 310

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:35 → 98

Ig; Immunoglobulin domain

cl21522
Location:112 → 202

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001172054.1 → NP_001165525.1 interleukin-11 receptor subunit alpha-1 precursor

See identical proteins and their annotated locations for NP_001165525.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1-3 all encode the same protein.

Source sequence(s)

AL807796

Consensus CDS

CCDS18071.1

UniProtKB/Swiss-Prot

A2AMS4, Q64385, Q6NSQ0

UniProtKB/TrEMBL

Q3UIV4

Related

ENSMUSP00000103675.2, ENSMUST00000108040.8

Conserved Domains (4) summary

smart00410
Location:33 → 95

IG_like; Immunoglobulin like

cd00063
Location:218 → 310

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:35 → 98

Ig; Immunoglobulin domain

cl21522
Location:112 → 202

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_010549.3 → NP_034679.1 interleukin-11 receptor subunit alpha-1 precursor

See identical proteins and their annotated locations for NP_034679.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, compared to variant 3. Variants 1-3 all encode the same protein.

Source sequence(s)

AK146742, AK159559, BY149476

Consensus CDS

CCDS18071.1

UniProtKB/Swiss-Prot

A2AMS4, Q64385, Q6NSQ0

UniProtKB/TrEMBL

Q3UIV4

Related

ENSMUSP00000103677.3, ENSMUST00000108042.3

Conserved Domains (4) summary

smart00410
Location:33 → 95

IG_like; Immunoglobulin like

cd00063
Location:218 → 310

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:35 → 98

Ig; Immunoglobulin domain

cl21522
Location:112 → 202

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...