Iglv1 immunoglobulin lambda variable 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iglv1provided by MGI
Official Full Name: immunoglobulin lambda variable 1provided by MGI
Primary source: MGI:MGI:96530
See related: Ensembl:ENSMUSG00000076934 IMGT/GENE-DB:IGLV1; AllianceGenome:MGI:96530
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igl-V1; 1810027O01Rik
Summary: Predicted to be involved in immune response. Predicted to be active in extracellular space. Orthologous to several human genes including IGLV7-43 (immunoglobulin lambda variable 7-43). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 16 A3; 16 11.82 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (18903767..18904210, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (19085017..19085460, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An analysis of the structures of lambda chains allows the definition of a discrete set of recurring conformations of their hypervariable loops and the identification of sequence constraints that can be used to predict their structure.
Title: Structural repertoire of immunoglobulin λ light chains.
L chain rearrangement that occurs in the periphery can contribute to affinity maturation of Ab.
Title: Contribution of light chain rearrangement in peripheral B cells to the generation of high-affinity antibodies.

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General gene information

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Markers

M94351 (e-PCR)
- UniSTS:125002

NoName (e-PCR)
- UniSTS:484995

AW494620 (e-PCR)
- UniSTS:180875

Other Names

A6 anti-[4-hydroxy-3-nitrophenyl(phenolate form)] acetyl mAb V-L region
immunoglobulin lambda chain, variable 1
immunoglobulin lambda-chain
imunoglobulin light chain variable region
light chain variable region

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin production	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_004051.1

Range

175885..176328

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GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

18903767..18904210 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_023499.1: Suppressed sequence

Description

NM_023499.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.