Igll1 immunoglobulin lambda-like polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igll1provided by MGI
Official Full Name: immunoglobulin lambda-like polypeptide 1provided by MGI
Primary source: MGI:MGI:96529
See related: Ensembl:ENSMUSG00000075370 AllianceGenome:MGI:96529
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igll; Igl-5; Lambda5
Summary: Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to be located in endoplasmic reticulum and extracellular region. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. Is expressed in embryo; liver; and yolk sac. Human ortholog(s) of this gene implicated in agammaglobulinemia. Orthologous to several human genes including IGLL1 (immunoglobulin lambda like polypeptide 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 12.8), liver E14.5 (RPKM 0.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 10.45 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (16678535..16681849, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (16860671..16863985, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the non-Ig part of lambda5 crosslinks precursor b-cell receptors for downregulation and stimulation.
Title: The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.
lambda5 differentially relies on the lambda-like Ig and unique region to probe H chain structure to best accommodate diversity among H chains.
Title: The unique and immunoglobulin-like regions of surrogate light chain component lambda5 differentially interrogate immunoglobulin heavy-chain structure.
Reduced surrogate light chain expression contributes to decreased production of pre-B lymphocytes in aged bone marrow and in young lambda5 gene knockout mice.
Title: Deviation of the B cell pathway in senescent mice is associated with reduced surrogate light chain expression and altered immature B cell generation, phenotype, and light chain expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igl-5 (e-PCR), detects polymorphism
- UniSTS:259395

Igll1 (e-PCR), detects polymorphism
- UniSTS:265574

Igl-5 (e-PCR), detects polymorphism
- UniSTS:143528

Igl-5 (e-PCR), detects polymorphism
- UniSTS:256437

BB139905 (e-PCR)
- UniSTS:186057

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of IgG immunoglobulin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: immunoglobulin lambda-like polypeptide 1

Names: CD179 antigen-like family member B; ig lambda-5; immunoglobulin lambda chain 5; lambda 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.